Results 111 to 120 of about 288,655 (359)

Raised serum transaminases during treatment with pegylated interferon for chronic hepatiti C [PDF]

, 2016
Introduction : Serum transaminases rose significantly in 7 patients with chronic hepatitis C, genotypes 2 and 3, who were treated with pegylated interferon and ribavirin. Methods : 219 patients with chronic hepatitis C, genotypes 2 and 3, were treated
Datta, S., Mandalou, P., Mills, P.R., Spence, E.   +3 more
core   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials [PDF]

, 2018
Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety ...
Atkinson, John P, Boyer, Ryan, Gu, Zhonghu, Gupta, Soumi, Harding, Cary O, Knight, Vijaya, Larimore, Kevin, Lau, Kelly, Li, Mingjin, Olbertz, Joy, Rosen, Orli, Shepherd, Gillian, Shweighardt, Becky, Weng, Haoling H, Zoog, Stephen J   +14 more
core   +2 more sources

Supercritical Fluid‐Processed Multifunctional Hybrid Decellularized Extracellular Matrix with Chitosan Hydrogel for Improving Photoaged Dermis Microenvironment

Advanced Healthcare Materials, EarlyView.
These findings advance tissue repair by offering a multifunctional filler that improves large‐scale volume retention, elasticity, and support for vascularized tissue growth. The decellularized extracellular matrix (dECM)‐based material provides low injection force and minimizes swelling, ensuring sustained volume. Combining CMC with supercritical fluid‐
Seol‐Ha Jeong, Jae Jun Kang, Ki‐Myo Kim, Mi hyun lee, Misun Cha, Su Hee Kim, Ji‐Ung Park   +6 more
wiley   +1 more source

Condensation of Self-assembled Lyotropic Chromonic Liquid Crystal Sunset Yellow in Aqueous Solutions Crowded with Polyethylene glycol and Doped with Salt [PDF]

Langmuir 27(7), 4164-4175 (2011), 2011
We use optical and fluorescence microscopy, densitometry, cryo-transmission electron microscopy (cryo-TEM), spectroscopy, and synchrotron X-ray scattering, to study the phase behavior of the reversible self-assembled chromonic aggregates of an anionic dye Sunset Yellow (SSY) in aqueous solutions crowded with an electrically neutral polymer polyethylene
arxiv  

Permeable, Non-irritating Prodrugs of Nonsteroidal and Steroidal Agents [PDF]

, 1997
Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine ...
Ashton, Paul, Conklin, John D., Crooks, Peter A., Cynkowska, Grazyna, Cynkowski, Tadeusz, Glavinos, Peter G., Riggs, Robert M., Smith, Thomas J.   +7 more
core   +1 more source

A rapid and simple assay to determine pegylated erythropoietin in human serum [PDF]

, 2010
Stimulation of erythropoiesis by the third-generation erythropoietin drug, continuous erythropoietin receptor activator (CERA), a pegylated derivative of epoetin-beta, has provided valuable therapeutic benefits to patients suffering from renal anemia ...
Delanghe, Joris, Dhondt, Annemieke, Van Maerken, Tom   +2 more
core   +1 more source

An In Situ Curing, Shear‐Responsive Biomaterial Designed for Durable Embolization of Microvasculature

Advanced Healthcare Materials, EarlyView.
NeoCast is a next‐generation, solvent‐free, non‐adhesive liquid embolic designed for indications where deep occlusion is desired (e.g., tumors and chronic subdural hematoma). This novel agent offers ideal embolic properties: injectability, controllability, excellent visibility, and biocompatibility.
Quynh P. Pham, Jeffrey V. Groom II, Chander Sadasivan, David J. Fiorella, David C. Madoff, Lee‐Jae Guo, Michael Fornaciari, Courtney Guertin, Craig Wiltsey, Lee Core, Jonathan Merlo, William Wustenberg, Renu Virmani, Adam S. Arthur, Robert S. Langer, George M. Whitesides, Upma Sharma   +16 more
wiley   +1 more source

Hydrogel Adhesive Integrated‐Microstructured Electrodes for Cuff‐Free, Less‐Invasive, and Stable Interface for Vagus Nerve Stimulation

Advanced Healthcare Materials, EarlyView.
In this study, a cuff‐free, less‐invasive surgical approach for vagus nerve stimulation (VNS) by combining ultrathin Y‐shaped kirigami electrodes is developed with a chemically cross‐linked hydrogel adhesive (hydrogel‐kirigami). Unlike conventional cuff implantation, which may damage nerves and nearby critical vessels, this new technique minimizes ...
Jae Young Park, Jongcheon Lim, Carl R. Russell III, Pei‐Lun Chen, Deniz Eksioglu, Seokkyoon Hong, Juan C. Mesa, Matthew P. Ward, Chi Hwan Lee, Hyowon Lee   +9 more
wiley   +1 more source

Response to dietary tannin challenges in view of the browser/grazer dichotomy in an Ethiopian setting : Bonga sheep versus Kaffa goats [PDF]

, 2015
It has been suggested that goats (typical browser) are better adapted to digest tannin-rich diets than sheep (typical grazer). To evaluate this, Bonga sheep and Kaffa goats were used in a 2x3 randomized crossover design with two species, three diets, and
Janssens, Geert, Kibreab, Yoseph, Ribeiro Alves Lourenço, Marta, Taye, Tolemariam, Yisehak, Kechero   +4 more
core   +1 more source