Results 101 to 110 of about 815,697 (298)

Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae.

open access: yesPLoS ONE, 2012
Zebrafish are rapidly growing in popularity as an in vivo model system for chemical genetics, drug discovery, and toxicology, and more recently also for natural product discovery. Experiments involving the pharmacological evaluation of small molecules or
Jan Maes   +5 more
doaj   +1 more source

Localized Hydrogen Release Driven by Mg–Pd Microgalvanic Cells from 3D‐Printed Microneedles Reverses Redox Homeostasis for Psoriasis Treatment

open access: yesAdvanced Science, EarlyView.
A 3D printing microneedle (MP‐MN), loading magnesium‐based micro‐galvanic cells (MP), is designed for improving psoriasis. H2 generated from MP‐MN scavenges ROS and •OH, actives NRF2‐KEAP1 pathway, and decreases inflammation, thereby effectively restoring the oxidative stress homeostasis of psoriatic skin and suppressing the excessive proliferation of ...
Xinyue Shao   +10 more
wiley   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

open access: yesAngewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao   +8 more
wiley   +1 more source

Development of an Effective Isolation Method for Plasma Extracellular Vesicles Excluding Lipoproteins by Precipitation With Polyethylene Glycol

open access: yesJournal of Extracellular Biology
Various molecules in plasma extracellular vesicles (EVs) are expected to be applied to minimally invasive diagnosis; however, the high concentration of lipoproteins in plasma, which are similar in size, density and content to EVs, hampers analysis on ...
Kosuke Otani   +3 more
doaj   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

open access: yesAngewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean   +3 more
wiley   +1 more source

Interference by vitamin B12-macrocomplexes: towards an effective detection and correct interpretation of hypo- and hypervitaminemia

open access: yesAdvances in Laboratory Medicine
The presence of macro-B12 is a cause of factual hypervitaminemia B12. Precipitation with polyethylene glycol (PEG) is a simple method of removing high-molecular-weight biomolecules. However, “free” molecule may co-precipitate.
Delgado José A.   +4 more
doaj   +1 more source

Synthesis and Optimization of Polyethylene Glycol Coated Magnetic Nanoparticles Used as D2EHPA Carriers [PDF]

open access: yesمجله علوم و فنون هسته‌ای, 2012
Fe3O4 magnetic nanoparticles were prepared by co-precipitation of FeCl3.6H2O and FeCl2.4H2O with addition of sodium hydroxide. The conditions for the preparation of Fe3O4 magnetic nanoparticles were optimized, and Fe3O4 magnetic nanoparticles obtained ...
K Saberyan   +3 more
doaj  

Concentration of Infectious Hematopoietic Necrosis Virus from Water Samples by Tangential Flow Filtration and Polyethylene Glycol Precipitation

open access: yes, 1989
Infectious hematopoietic necrosis virus (IHNV) was concentrated from water samples by polyethylene glycol (PEG) precipitation, tangential flow filtration (TFF), and by a combination of TFF followed by PEG precipitation of the retentate.
W. N. Batts, J. R. Winton
core   +1 more source

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