Results 141 to 150 of about 35,820 (275)

Synthesis, modification, and chlorhexidine loading of polymer modified‐HM‐HAP particles: In vivo antibacterial analysis and cell cytotoxicity assessment

Smart Molecules, EarlyView.
This study presents the synthesis of hollow mesoporous hydroxyapatite (HM‐HAP) particles modified with different weights PEG and PEI. Chlorhexidine was loaded onto the particles. SEM analysis confirmed no significant morphological changes. Antibacterial activity was tested in vitro and in vivo using mouse oral bacteria, demonstrating promising results.
Farishta Shafiq, Chenyu Liu, Simiao Yu, Yongxin Pan, Min Ji, Qingzhao Shi, Weihong Qiao   +6 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Correction: Synergistic adsorption of ciprofloxacin on an amine-functionalized Zn-MOF/chitosan-polyethylenimine composite sponge: experimental and statistical optimization and biological activity. [PDF]

RSC Adv
Aljohani MM, Alharthi SG, Alhawiti AS, Alkhathami N, Alahmari H, Obaid AO, El-Metwaly NM.   +6 more
europepmc   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Electrochemical Reduction of Amine-Captured Carbon Dioxide Catalyzed by Transition-Metal Substituted Polyoxometalates. [PDF]

Molecules
Azaiza-Dabbah D, Neumann R.
europepmc   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Stimuli-Responsive Polyethylenimine Derivatives as Carriers for siRNA Delivery: Current Solutions and Future Perspectives. [PDF]

ACS Omega
Kołacki O, Trzciński S, Chmielewski MK.   +2 more
europepmc   +1 more source

Interaction with NEGR1 affects mGlu5 cell signalling and the neuroprotection induced by the positive allosteric modulator VU0409551

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The metabotropic glutamate receptor mGlu5 plays an important role in neuronal survival and synaptic plasticity. We and others have shown that mGlu5 positive allosteric modulators (PAMs) are biased agonists, triggering the activation of neuroprotective pathways and promoting neuronal survival. As mGlu5 biased pharmacology
Jennifer D. S. Guimaraes, Toniana G. Carvalho, Luan A. Pereira, Emanuele G. Silva, Esther M. A. Maciel, Gabriella P. Torres, Thiago Assis, Pablo L. Cardozo, Joao P. P. de Almeida, Nathalia C. Silva, Francesca Pischedda, Giovanni Piccoli, Luciene B. Vieira, Juliana Alves‐Silva, Fabiola M. Ribeiro   +14 more
wiley   +1 more source

Polyethylenimine-Conjugated Au-NPs as an Efficient Vehicle for in vitro and in vivo DNA Vaccine Delivery

International Journal of Nanomedicine
Aras Kartouzian,1 Alexandra Heiz,1 Kamyar Shameli,2,* Hassan Moeini3,* 1Catalysis Research Center, School of Natural Sciences, Technical University of Munich, Munich, Germany; 2Institute of Virology, School of Medicine, Technical University of ...
Kartouzian A, Heiz A, Shameli K, Moeini H   +3 more
doaj  

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source