Results 161 to 170 of about 4,131 (247)

Contilisant-Belinostat Hybrids: Polyfunctionalized Indole Derivatives as Multineurotarget Drugs for the Potential Treatment of Alzheimer's Disease. [PDF]

ACS Pharmacol Transl Sci
In this work, we designed, synthesized, and evaluated two types of multineurotargeting compounds using a pharmacophore merging strategy, aiming to develop potential treatments for Alzheimer's disease.
Linda Schäker-Hübner, Mireia Toledano-Pinedo, Sophia Eimermacher, Vesa Krasniqi, Alicia Porro-Pérez, Kathrin Tan, G. Horn, Philipp Stegen, P. Elsinghorst, T. Wille, Markus Pietsch, Michael Gütschow, José Marco-Contelles, Finn K. Hansen   +13 more
semanticscholar   +2 more sources

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Development of polyfunctionalized biochar modified with manganese oxide and sulfur for immobilizing Hg(II) and Pb(II) in water and soil and improving soil health

Science of the Total Environment
Mercury (Hg) and lead (Pb) pose significant risks to human health due to their high toxicity and bioaccumulative properties. This study aimed to develop a novel biochar composite (HMB-S), polyfunctionalized with manganese dioxide (α-MnO2) and sulfur ...
Hui Huang
exaly   +2 more sources

Imin-based synthesis of polyfunctionalized dihydro-2-oxypyrroles catalyzed by glycine amino acid via tandem Michael–Mannich cyclocondensation reaction under ambient temperature

Research on Chemical Intermediates, 2020
Farzaneh Mohamadpour
exaly   +2 more sources

Photo-Driven Synthesis of C6-Polyfunctionalized Phenanthridines from Three-Component Reactions of Isocyanides, Alkynes, and Sulfinic Acids by Electron Donor–Acceptor Complex

Organic Letters, 2018
Tao Miao, Pinhua Li, Lei Wang
exaly   +2 more sources

"Alkene-to-Alkene" Difunctionalization of Enaminones for the Synthesis of Polyfunctionalized Alkenes by Transition-Metal-Free C-H and C-N Bond Transformation.

Organic Letters, 2023
The three-component reactions of enaminones, disulfides, and alcohols for the synthesis of polyfunctionalized alkenes have been realized via the C-H and C-N bond transformation on enaminones.
Jingfeng Ye, Yunyun Liu, Jin Luo, Jie‐Ping Wan   +3 more
semanticscholar   +1 more source

Synthesis, molecular modeling Insights, and anticancer assessment of novel polyfunctionalized Pyridine congeners.

Bioorganic chemistry (Print), 2023
The present study describes synthesizing a novel series of polyfunctionalized pyridine congeners 1-18 and assessed for cytotoxic efficacies versus HCT-116, MCF-7, and HepG-2 among one non-cancerous BJ-1 human normal cell.
Mohamed G. Abouelenein, A. El‐Rashedy, Hanem M. Awad, A. F. El Farargy, I. Nassar, Amr Nassrallah   +5 more
semanticscholar   +1 more source

Visible-Light-Mediated Solvent-Switched Photosensitizer-Free Synthesis of Polyfunctionalized Quinolines and Pyridines.

Organic Letters, 2023
A solvent (2,2,2-trifluoroethanol (TFE) vs ethyl alcohol (EtOH)) switched synthesis of quinolines and pyridines is illustrated from (E)-2-(1,3-diphenylallylidene)malononitriles via a Pd(II)-catalyzed photochemical process.
Hirendranath Dhara, A. Rakshit, Tipu Alam, A. Sahoo, B. Patel   +4 more
semanticscholar   +1 more source

Copper-Catalyzed One-Step Formation of Four C-N Bonds toward Polyfunctionalized Triazoles via Multicomponent Reaction.

Organic Letters, 2022
A novel four-component reaction of alkynes, amines, azides, and 2H-azirines has been developed for the first time by the efficient formation of four C-N bonds in one step under mild conditions, rapidly preparing polyfunctionalized triazoles with ...
Xuelun Duan, Nan Zheng, Gongbo Liu, Ming Li, Qiming Wu, Xin Sun, Wangze Song   +6 more
semanticscholar   +1 more source

Direct C-H Carboxylation Forming Polyfunctionalized Aromatic Carboxylic Acids by Combined Brønsted Bases.

Organic Letters, 2022
CO2 fixation into electron-deficient aromatic C-H bonds proceeds with the combined Brønsted bases LiO-t-Bu and LiO-t-Am/CsF/18-crown-6 (t-Am = CEtMe2) under a CO2 atmosphere to afford a variety of polyfunctionalized aromatic carboxylic acids.
Masanori Shigeno, Kazuya Hanasaka, Itsuki Tohara, Koki Izumi, Hiroyuki Yamakoshi, Eunsang Kwon, Kanako Nozawa‐Kumada, Y. Kondo   +7 more
semanticscholar   +1 more source

Stereoselective Access to Polyfunctionalized Nine-Membered Heterocycles by Sequential Gold and Palladium Catalysis.

Angewandte Chemie, 2021
We report herein a gold and palladium sequential catalysis system to access furan-fused nine-membered heterocycles in high efficiency and enantioselectivity.
Guoqiang Yang, Ya‐Ming Ke, Yu Zhao
semanticscholar   +1 more source