Results 141 to 150 of about 27,060 (161)

Bioactivity screening, extraction, and separation of lactate dehydrogenase inhibitors from Polygala tenuifolia Willd. based on a hyphenated strategy

Journal of Separation Science, 2017
Stroke is the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are currently widely used in the treatment of ischemic stroke, and natural products are considered promising sources of lactate dehydrogenase inhibitors. In this study, ultrafiltration liquid chromatography coupled with mass spectrometry was used for the screening ...
Sainan, Li, Shu, Liu, Zhiqiang, Liu, Chunming, Liu, Fengrui, Song, Zifeng, Pi   +5 more
openaire   +2 more sources

Đặc Điểm Hình Thái, Vi Phẫu Và Đặc Điểm SOI Bột Loài Viễn Chí Polygala Tenuifolia Willd.

Tạp Chí Khoa Học Và Công Nghệ - Đại Học Thái Nguyên
Polygala là chi tiêu biểu nhất của họ Viễn chí (Polygalaceae). Loài Viễn chí Polygala tenuifolia là một trong số 8 loài trong chi đã được nghiên cứu thành phần hóa học, hoạt chất để sử dụng trong y học cổ truyền. Rễ của Polygala tenuifolia có khả năng chống lại tình trạng chết thần kinh, chống viêm và chống suy giảm nhận thức ở bệnh Alzheimer.
Nguyen Thi Thuy
exaly   +2 more sources

Oligosaccharide esters with neuroprotective activities isolated from the roots of Polygala tenuifolia Willd.

Phytochemistry
Nine previously undescribed oligosaccharide esters (1-9), designated as tenuifolioses I-IX, along with nine known analogues (10-18), were isolated from the roots of Polygala tenuifolia Willd. Structural characterization of the novel compounds was achieved through comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS data.
Yang, Guo, Xiangyang, Liu, Meng, Ding, Qiqi, Wang, Panfeng, Xie, Hongbing, Zhang, Yong, Jiang   +6 more
openaire   +2 more sources

Protective effects of tenuifolin isolated from Polygala tenuifolia Willd roots on neuronal apoptosis and learning and memory deficits in mice with Alzheimer's disease

Food & Function, 2019
The roots of Polygala tenuifolia Willd have a long history of being used as a traditional Chinese medicine for the treatment of insomnia, forgetfulness, sorrow and depression. This research show the special function in Alzheimer's disease.
Lin Wang, Gui Fang Jin, He Han Yu, Xiao Hua Lu, Zhen Hua Zou, Jia Qi Liang, Hong Yang   +6 more
openaire   +2 more sources

Isolation and identification of tetrahydrocolumbamine as a dopamine receptor ligand from Polygala tenuifolia Willd.

Yao xue xue bao = Acta pharmaceutica Sinica, 1995
The isolation and purification of a dopamine receptor ligand, tetrahydrocolumbamine from Polygala tenuifolia Willd is described. Tetrahydrocolumbamine was shown to inhibit the binding of [3H]-SCH23390 and [3H]-spiroperidol to rat striatum membranes in vitro with IC50 values of 0.75 +/- 0.08 mumol.L-1 and 0.92 +/- 0.10 mumol.L-1, respectively.
X L, Shen, M R, Witt, K, Dekermendjian, M, Nielsen   +3 more
openaire   +1 more source

[Observation on propagating experiments with Polygala tenuifolia Willd seed].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1989
This paper reports the harvesting and storing of Polygala tenuifolia seed, the operating process and method of seed propagation both in the laboratory and in the field, the relationship between Palygala tenuifolia seed germination, seed treatment and temperature and humidity, and the importance of suitable conditions and climatic factors in the sexual ...
openaire   +1 more source

Compatibility of Acorus tatarinowii Schott and Polygala tenuifolia Willd. alleviate Alzheimer’s disease through regulating Nos2-mediated calcium signaling pathway

Neurochemical Research
Herb pair of Acorus tatarinowii Schott (ATS) and Polygala tenuifolia Willd. (PTW) is a classic drug pair in the treatment of Alzheimer's disease (AD), However, the mechanism by which the drug pair acts on AD is currently unknown. To address this, we constructed a PC12 cellular AD model using amyloid-beta peptide (Aβ) (25-35), follow by treating with ...
Bingling, Zhou, Xiao, Wu, Junli, Wang, Lijuan, Li, Huifang, Xu, Wei, Shao   +5 more
openaire   +2 more sources

Polygala Tenuifolia Willd. Ameliorates Neuronal Damage in Alzheimer’s Disease Model Mice by Regulating Ferroptosis Through Modulation of the Nrf2/SLC7A11/GPX4 Axis

Applied Biochemistry and Biotechnology
This study aimed to explore the effects of Polygala-containing Formula (PCF) on ferroptosis and cognitive dysfunction in both Alzheimer’s disease (AD) mouse models and in cell-based experiments. A mouse model of AD was established in male mice using Aβ1-42. After successful model induction, mice were intraperitoneally injected with different dosages of
GuiYing Qian, JiaShuang Zou, QiuYa Huang, MianSheng Gao, Yu Sun, XiDong Wu, LiFang Gu, YunYing Qian, XiaoMing Wu   +8 more
openaire   +2 more sources

Polygala tenuifolia willd. Extract alleviates LPS-induced acute lung injury in rats via TLR4/NF-κB pathway and NLRP3 inflammasome suppression

Phytomedicine
Acute lung injury (ALI) has received considerable attention in the field of critical care as it can lead to high mortality rates. Polygala tenuifolia, a traditional Chinese medicine with strong expectorant properties, can be used to treat pneumonia. Owing to the complexity of its composition, the main active ingredient is not yet known.
Shuyun Guo, Jianguang Zhang, Qian Zhang, Shuang Xu, Yuezhen Liu, Shangzhi Ma, Xiaodi Hu, Yanju Liu, Xiuqiao Zhang, Ruixue Jiang, Zhifeng Zhang, Zhihua Zhang, Zhongshi Zhou, Li Wen   +13 more
openaire   +2 more sources

Trehalose and brassinolide enhance the signature ingredient accumulation and anti-oxidant activity in the hairy root cultures of Polygala tenuifolia Willd.

Industrial Crops and Products, 2023
Haiyue Ji, Bingyue Yang, Yiyao Jing, Yao Luo, Bo Li, Yonggang Yan, Gang Zhang, Fan Zhao, Bangqing Wang, Liang Peng, Benxiang Hu   +10 more
openaire   +1 more source