Polygalae Radix shortens the circadian period through activation of the CaMKII pathway [PDF]
Pharmaceutical Biology, 2022 Context The mammalian circadian clock system regulates physiological function. Crude drugs, containing Polygalae Radix, and Kampō, combining multiple crude drugs, have been used to treat various diseases, but few studies have focussed on the circadian ...
Atsushi Haraguchi +3 more
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Polygalae Radix: Review of Metabolites, Pharmacological Activities and Toxicology [PDF]
Frontiers in PharmacologyPolygalae Radix: is the dried root of Polygala tenuifolia Willd. or Polygala sibirica L., which has the effect of improving memory and cognitive function in traditional Chinese medicine.
Meihua Liu, Xin Wang, Dejiang Gao
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Effects of Radix Polygalae on Cognitive Decline and Depression in Estradiol Depletion Mouse Model of Menopause [PDF]
Current Issues in Molecular Biology, 2021 Postmenopausal syndrome refers to symptoms caused by the gradual decrease in female hormones after mid-40 years. As a target organ of estrogen, decrease in estrogen causes various changes in brain function such as a decrease in choline acetyltransferase ...
Heeok Hong, Sungho Maeng, Byung-il Kim
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Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer’s Disease [PDF]
Frontiers in Pharmacology, 2017 Memory impairments in Alzheimer’s disease (AD) occur due to degenerated axons and disrupted neural networks. Since only limited recovery is possible after the destruction of neural networks, preventing axonal degeneration during the early stages of ...
Tomoharu Kuboyama +4 more
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Study on the Dynamic Changes in Fungal Communities During the Storage of Polygalae Radix and the Antifungal Effects of Peppermint Essential Oil [PDF]
ToxinsPolygalae Radix, a traditional Chinese medicine for insomnia and memory disorders, is highly susceptible to fungal contamination and mycotoxin production (especially by Aspergillus flavus) during storage, compromising its safety and efficacy.
Hui Zhang +5 more
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Protective Effects and Mechanism of Radix Polygalae Against Neurological Diseases as Well as Effective Substance [PDF]
Frontiers in Psychiatry, 2021 Radix Polygalae (also known as Yuanzhi in China) is the dried rhizome of Polygala tenuifolia Willd. or Polygala sibirica L., which is a famous Chinese herb and has been widely used for centuries in traditional medicines including expectorants, tonics ...
Xin-Min Liu
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A Review of the Botany, Metabolites, Pharmacology, Toxicity, Industrial Applications, and Processing of Polygalae Radix: The “Key Medicine for Nourishing Life” [PDF]
Frontiers in PharmacologyPolygalae radix (PR) is the dried root of Polygala tenuifolia Willd. and Polygala sibirica L. and enjoys the reputation as the “key medicine for nourishing life.” In this study, information about “Polygala tenuifolia Willd.,” “Polygala sibirica L.,” and “
Hai Jiang
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3,6′-Disinapoyl Sucrose from Polygalae Radix Exerts Anti-Aging Effects via Modification of Telomeres, SIRT1/p53/p21 Pathway, Oxidative Stress and Autophagy [PDF]
AntioxidantsTraditional Chinese medicine plays an important role in human health, but due to the complexity of its active fraction, its therapeutic mechanism still needs further clarification.
Jianhong Wang +6 more
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Exploring the Role of Radix Polygalae in Melanogenesis Related to Vitiligo: A Network Pharmacology Analysis with in vitro Validation [PDF]
Clinical, Cosmetic and Investigational DermatologyLu Zhu,1,* Yixuan Liang,1,2,* Ling Jiang,1 Chuhan Fu,1 Xixia Dai,1 Haoran Guo,1 Qinghai Zeng,1 Shuanghai Hu,3 Jing Chen1 1Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, People’s ...
Zhu L +8 more
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Comprehensive evaluation of chemical constituents and antioxidant activity between crude and processed Polygalae radix based on UPLC-Q-TOF-MS/MS combined with multivariate statistical analysis [PDF]
HeliyonPolygalae radix (PR) is a famous herbal medicine obtained by drying the root of Polygala tenuifolia Willd., one of the traditional Chinese medicines (TCM) that can be used for healthy food. There are three main processed methods of PR, including removing
Yao Luo +10 more
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