Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract.
PLoS ONE, 2014 Radix Polygalae (the root of Polygala tenuifolia) is a herb widely used in traditional Asian medicine that is thought to exert a variety of neuropsychiatric effects.
Im-Joon Shin +12 more
doaj +5 more sources
Molecules, 2018 The root of Polygala tenuifolia Willd. or Polygala sibirica L. exhibits protective effects on the central nervous system and is frequently used to treat insomnia, amnesia, and other cognitive dysfunction. In our study, we studied nine bioactive compounds
Xin Chai, Yuefei Wang, Huijuan Yu
exaly +4 more sources
Polygalae Radix Oligosaccharide Esters May Relieve Depressive-Like Behavior in Rats With Chronic Unpredictable Mild Stress via Modulation of Gut Microbiota [PDF]
International Journal of Molecular Sciences, 2023 Polygalae radix (PR) is a well-known traditional Chinese medicine that is used to treat depression, and polygalae radix oligosaccharide esters (PROEs) are the main active ingredient. Although gut microbiota are now believed to play key role in depression,
Yinying Ba, Xia Wu, Xiaoqing Chen
exaly +3 more sources
Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice [PDF]
Frontiers in Psychiatry, 2017 The therapeutic goal for the treatment of posttraumatic stress disorder (PTSD) is to promote extinction and to prevent the relapse of fearful memories. Research has identified pharmacological treatments that may regulate the formation and extinction of ...
Jung-Won Shin +8 more
doaj +5 more sources
MS‐based multi‐dimensional metabolomics reveals protective effect of Polygalae Radix against metabolic disturbances in Alzheimer's disease mice [PDF]
Clinical and Translational MedicineClinical and Translational Medicine, Volume 15, Issue 4, April 2025.
Yanwen Chen +5 more
doaj +3 more sources
Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments. [PDF]
PLoS ONE, 2016 Decline of cognitive function is the hallmark of Alzheimer's disease (AD), regardless of the pathological mechanism. Traditional Chinese medicine has been used to combat cognitive impairments and has been shown to improve learning and memory.
Xiaohang Li +10 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2016 Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix.
Chang-Yuan Chen +2 more
doaj +2 more sources
UPLC/Q-TOF MS-based metabolomics and qRT-PCR in enzyme gene screening with key role in triterpenoid saponin biosynthesis of Polygala tenuifolia. [PDF]
PLoS ONE, 2014 BackgroundThe dried root of Polygala tenuifolia, named Radix Polygalae, is a well-known traditional Chinese medicine. Triterpenoid saponins are some of the most important components of Radix Polygalae extracts and are widely studied because of their ...
Fusheng Zhang +6 more
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Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits. [PDF]
PLoS ONE, 2014 Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives ...
Yujun Hou +12 more
doaj +2 more sources
Exploring the patterns in traditional Chinese medicine for bipolar disorder: a data-driven network approach [PDF]
Frontiers in PharmacologyAim of the studyTraditional Chinese Medicine offers a holistic approach that could provide complementary benefits for bipolar disorder treatment. However, the clinical cases in Traditional Chinese Medicine are highly dispersed, creating challenges for ...
Zhenshan Sun +8 more
doaj +2 more sources