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Onjisaponin B Derived From Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells

open access: yesInternational Journal of Molecular Sciences, 2013
Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins.
Vincent Kam Wai Wong   +2 more
exaly   +2 more sources
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Polygalae Radix: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, Toxicology, and Pharmacokinetics

Fìtoterapìâ, 2020
Polygalae Radix (Polygalaceae), the dried root of Polygala tenuifolia Willd. and Polygala sibirica L., has been widely used as a medicine for improving cognitive function. In China, Polygalae Radix has been widely used in the treatment of insomnia, forgetfulness, depression, cough, palpitation, and other diseases.
Xin Zhao, Xue-Lan Zhang, Pan Zhao
exaly   +3 more sources

Effects of Polygalae Radix on Apotosis in PC-12 Cell [PDF]

open access: yesThe Korea Journal of Herbology, 2015
Youn-Sub Kim
exaly   +2 more sources

[Quantitative determination of sibricose A5 and sibricose A6 in Polygalae radix].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012
To establish the method for quantitative determination of sibricose A5 and sibricose A6 in Polygalae Radix by HPLC.The ultrasonic extracting method was applied in sample pre-treatment. The HPLC procedure was performed on the chromatographic column of Agela Promosil C18 (4.6 mm x 250 mm, 5 microm), the mobile phase was acetonitrile-0.1% phosphoric acid ...
Changqing, Sun   +7 more
openaire   +2 more sources

Potential antidepressant properties of Radix Polygalae (Yuan Zhi)

Phytomedicine, 2010
Radix Polygalae ("Yuan Zhi", the roots of Polygala tenuifolia Willd., YZ) is an important herb used in traditional Chinese medicine to mediate depression. The present study was designed to verify the antidepressant effects of the standardized YZ ethanol extract (YZE) and its four fractions YZ-30, YZ-50, YZ-70 and YZ-90 on the tail suspension (TST) and ...
P, Liu   +7 more
openaire   +2 more sources

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