Results 141 to 150 of about 14,947 (169)

Polygalae Radix Inhibits Toxin-Induced Neuronal Death in the Parkinson's Disease Models

Journal of Ethnopharmacology, 2011
Polygalae radix, the root of Polygala tenuifolia Willd, has commonly been used for the treatment of amnesia and anxiety in traditional Korean medicine. The aim of this study was to investigate its neuroprotective effects and possible mechanisms of action in models of Parkinson's disease.This study utilized a 3-(4,5-dimethylthiazol-2-yl)-2,5 ...
Woong Mo Yang, Sun Yeou Kim, Myung Sook Oh   +2 more
exaly   +3 more sources

[Research progress on Polygalae Radix].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2021
Polygalae Radix has long been used in China for calming the mind, promoting intelligence, communicating the heart and kidney, eliminating phlegm, and reducing swelling. At present, it is used to treat amnesia, insomnia, and malaise. Modern research has revealed that Polygalae Radix mainly contains triterpenoid saponins, xanthone, oligosaccharide esters,
Lu, Liu, Wei-Hong, Feng, Xiao-Qian, Liu, Yao-Hua, Liang, Chun, Li, Zhi-Min, Wang   +5 more
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Effect of Radix Polygalae extract on the colonic dysfunction in rats induced by chronic restraint stress

Journal of Ethnopharmacology, 2022
Radix Polygalae, a commonly used traditional Chinese herb, has conventionally functioned in tranquilization and sedation, where anti-inflammation may be the underlying mechanism.Chronic restraint stress (CRS), a risk factor for the etiology of intestinal disorders, was used in the present study to examine whether Radix Polygalae extract (RPE) could ...
Chen-Chen Li, Fan Ye, Chen-Xi Xu, Qi Chang, Xin-Min Liu, Rui-Le Pan   +5 more
openaire   +2 more sources

Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia)

Genes & Genomics
In Korea, only Polygala tenuifolia is registered as Polygalae Radix in the pharmacopoeia, while in China, both P. tenuifolia and P. sibirica are used equally. Accurate identification of herbal medicines is crucial for their safety and efficacy, but commercial products are typically sold in dried form, making morphological distinction difficult ...
Sumin Jeong, Jong Won Han, Yeseul Kim, Eunjeong Bak, Kyung Ho Ma, Jeong Hoon Lee, Jin Tae Jung, Inkyu Park   +7 more
openaire   +2 more sources

[CiteSpace knowledge map of research hotspots and frontiers of Polygalae Radix].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023
In this study, the Web of Science and China National Knowledge Infrastructure(CNKI) were searched comprehensively for the literature about the research on Polygalae Radix. After manual screening, 1 207 Chinese articles and 263 English articles were included in this study.
Hong-Jun, Zhou, Lu, Zhang, Jin-Hao, Zeng, Zhi-Lei, Wang, Li, Liu, Ju, Huang, Wen-Hao, Liao, Feng-Chen, Jin, Yu-Jie, Wei, Jian-Yuan, Tang   +9 more
openaire   +1 more source

Correlation between environmental factors and liposoluble and hydrophilic constituents of Polygalae Radix

China Journal of Chinese Materia Medica, 2011
OBJECTIVE To analyze the correlation between environmental factors and the lipophilic and hydrophilic constituents of Polygalae Radix. METHOD The contents of lipophilic constituent were determined by GC-MS and hydrophilic constituents by HPLC. Geographical factors were collected by on-site inspection and climate factors by the local meteorological data.
Minfeng, Fang, Yang, Wu, Ming, Yue, Wenting, Tang, Yanting, Fu, Guifang, Zhao   +5 more
openaire   +3 more sources

Biotransformation and its effects on anxiolytic activity and toxicity of Polygalae Radix saponins

Journal of Chromatography B
Saponins, accounting for over 2.0% (w/w) in Polygalae Radix extracts, act as both active and toxic constituents, with their glycosyl structures hypothesized to modulate efficacy and toxicity. This study aimed to modify the glycosyl structures of Polygalae Radix (PR) saponins via snail enzyme biotransformation and evaluate changes in the activity of ...
Yuhan, Sun, Yihong, Li, Jiaqi, Xie, Yulu, Liang, Hongqian, Kui, Huang, Jianmei   +5 more
openaire   +2 more sources

A novel strategy on the study of whole intestinal metabolic profiles for Polygalae Radix before and after processing

Phytochemical Analysis, 2023
Abstract Introduction Relieving toxicity and enhancing a calming effect after processing Polygalae Radix (PR) are widely known. Aromatic carboxylic acids (ACAs) may be crucial processed products. However, due to the limited detection methods for ACAs, the whole metabolic profiles via intestinal
Ningning Zhao, Junpeng Xing, Zhong Zheng, Fengrui Song, Zhiqiang Liu, Shu Liu   +5 more
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Glycyrrhizae radix et rhizoma processing ameliorates adverse reactions of polygalae radix in zebra fish and rabbit models

Journal of Ethnopharmacology
Polygala tenuifilia Willd (Polygalaceae), a traditional Chinese medicine, has been used for a long time to treat various illnesses with serious adverse reactions. Glycyrrhizae radix et rhizoma processing is generally used to reduce the adverse reactions.The aim of this study was to validate the irritation caused by raw Polygalaceae (RPA), to ...
Shi-Hao, Chen, Qi-Wu, Jiang, Su-Han, Yang, Bei-Bei, Lv, Zi-Xuan, Ma, Ping, Li, Wei-Long, Xu, Fei, Li   +7 more
openaire   +2 more sources

Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice

Phytomedicine, 2016
Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities.
Qing, Cao, Yong, Jiang, Su-Ying, Cui, Peng-Fei, Tu, Yue-Mei, Chen, Xiao-Li, Ma, Xiang-Yu, Cui, Yuan-Li, Huang, Hui, Ding, Jin-Zhi, Song, Bin, Yu, Zhao-Fu, Sheng, Zi-Jun, Wang, Ya-Ping, Xu, Guang, Yang, Hui, Ye, Xiao, Hu, Yong-He, Zhang   +17 more
openaire   +2 more sources