Results 91 to 100 of about 65,839 (347)

Polygenic risk scores: An overview from bench to bedside for personalised medicine [PDF]

, 2022
Benjamin Cross, Richard Turner, Munir Pirmohamed   +2 more
openalex   +1 more source

Independent associations of TOMM40 and APOE variants with body mass index [PDF]

, 2019
The TOMM40-APOE variants are known for their strong, antagonistic associations with Alzheimer's disease and body weight. While a stronger role of the APOE than TOMM40 variants in Alzheimer's disease was suggested, comparative contribution of the TOMM40 ...
Arbeev, Konstantin G, Bagley, Olivia, Christensen, Kaare, Culminskaya, Irina, Feitosa, Mary F, Huang, Jian, Kulminski, Alexander M, Loika, Yury, Long Life Family Study Research Group,, Yashin, Anatoliy I, Zmuda, Joseph M   +10 more
core   +2 more sources

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, EarlyView.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

Penalized regression and model selection methods for polygenic scores on summary statistics.

PLoS Computational Biology, 2020
Polygenic scores quantify the genetic risk associated with a given phenotype and are widely used to predict the risk of complex diseases. There has been recent interest in developing methods to construct polygenic risk scores using summary statistic data.
Jack Pattee, Wei Pan
doaj   +1 more source

Interaction of HPA axis genetics and early life stress shapes emotion recognition in healthy adults [PDF]

, 2018
Background: Early life stress (ELS) affects facial emotion recognition (FER), as well as the underlying brain network. However, there is considerable inter-individual variability in these ELS-caused alterations. As the hypothalamic-pituitary-adrenal (HPA)
Bajbouj, Malek, Dziobek, Isabel, Fan, Yan, Grimm, Simone, Gärtner, Matti, Hartling, Corinna, Trilla, Irene, Weigand, Anne   +7 more
core   +1 more source

Transforming Brain Health With Neurotechnology Convergence (Part II): Intelligent Neurointervention Systems for Neurological Disorders

Brain Health, EarlyView.
ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in ...
Qing Ye, Fei Peng, Chao Pan, Ping Zhang, Xuewei Xie, Zixiao Li, Yingxin Tang, Danyang Chen, Yuanwei Li, Jiawen Wu, Zao Han, Qing Dai, Quansheng Gu, Jizong Zhao, Zhouping Tang   +14 more
wiley   +1 more source

Applying polygenic risk scores to postpartum depression [PDF]

Archives of Women's Mental Health, 2014
The etiology of major depressive disorder (MDD) is likely to be heterogeneous, but postpartum depression (PPD) is hypothesized to represent a more homogenous subset of MDD. We use genome-wide SNP data to explore this hypothesis.
Byrne EM, Carrillo-Roa T, Penninx BW, Sallis HM, Viktorin A, Chapman B, Henders AK, Psychiatric Genomic Consortium Major Depressive Disorder Working Group, Pergadia ML, Heath AC, Madden PA, Sullivan PF, Boschloo L, van Grootheest G, McMahon G, Lawlor DA, Landén M, Lichtenstein P, Magnusson PK, Evans DM, Montgomery GW, Boomsma DI, Martin NG, Meltzer-Brody S, Wray NR   +24 more
openaire   +6 more sources

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

Variability of polygenic prediction for body mass index in Africa

Genome Medicine
Background Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent ...
Tinashe Chikowore, Kristi Läll, Lisa K. Micklesfield, Zane Lombard, Julia H. Goedecke, Segun Fatumo, Shane A. Norris, Reedik Magi, Michele Ramsay, Paul W. Franks, Guillaume Pare, Andrew P. Morris   +11 more
doaj   +1 more source

Polygenic risk scores: from research tools to clinical instruments

Genome Medicine, 2020
Genome-wide association studies have shown unequivocally that common complex disorders have a polygenic genetic architecture and have enabled researchers to identify genetic variants associated with diseases.
Cathryn M. Lewis, Evangelos Vassos
doaj   +1 more source