Results 161 to 170 of about 65,839 (347)

Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years [PDF]

, 2023
Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker, Hermann Brenner   +9 more
openalex   +1 more source

Impact of Alcohol Intake on Parkinson's Disease Risk and Progression: A Systematic Review and Dose–Response Meta‐Analysis of Prospective Studies

Movement Disorders, EarlyView.
Abstract The association between alcohol consumption and Parkinson's disease (PD) risk remains unclear, whereas smoking has an inverse relationship with the disease. This study systematically reviewed and meta‐analyzed 16 studies (2014–2024) from PubMed, Scopus, Web of Science, MEDLINE, and the Cochrane Library to assess the relationship between ...
Sahar Hemeda, Mohammed Elmadani, Mohammed Merzah, Aseel Odeh, Evelyn Pintér, István Balás, József Janszky, Dávid Pintér, Norbert Kovács   +8 more
wiley   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Resilience through diversity: The potential of modelling species and variety interactions to enhance resilience of production systems

PLANTS, PEOPLE, PLANET, EarlyView.
Agricultural production systems in the global North combine monocultures of specialised varieties and breeds with external interventions and inputs. Increasing the diversity of varieties, breeds and species may increase the system's resilience to external pressures through beneficial interactions.
Marinus J. M. Smulders, Gerbrich Bonekamp, Peter M. Bourke, Joukje Buiteveld, Janneke A. Dieleman, Anna Edlinger, Mark van Hoogdalem, Martina Huber, Jan ten Napel, Maarten van der Meer, Andries A. Temme, Pieter H. B. de Visser, Jorad de Vries, Sipke‐Joost Hiemstra   +13 more
wiley   +1 more source

Speciation with gene flow

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long, Xu Zhang, Yue Yu, Gregory L. Owens, Diana J. Rennison, Clarisse Palma‐Silva, Daniel Ortiz‐Barrientos, Loren H. Rieseberg   +7 more
wiley   +1 more source

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease [PDF]

, 2023
Hyun‐Sik Yang, Ling Teng, Daniel W. Kang, Vilas Menon, Tian Ge, Hilary K. Finucane, Aaron P. Schultz, Michael J Properzi, Hans‐Ulrich Klein, Lori B. Chibnik, Julie A. Schneider, David A. Bennett, Timothy J. Hohman, Richard Mayeux, Keith A. Johnson, Philip L. De Jager, Reisa A. Sperling   +16 more
openalex   +1 more source

In vitro evaluation of azole fungicide sensitivity in Fusarium langsethiae, F. tricinctum, F. poae and F. sporotrichioides populations from Irish oats

Pest Management Science, EarlyView.
Microtitre plate assays of 286 Irish oat isolates show species‐specific azole sensitivity. In Fusarium langsethiae, mefentrifluconazole and tebuconazole sensitivities correlate, defining four phenotypes and supporting resistance monitoring and integrated control.
Diana E. Bucur, Steven Kildea
wiley   +1 more source

Risk factors affecting polygenic score performance across diverse cohorts [PDF]

, 2023
Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L. Walunas, Iftikhar J. Kullo, Wei‐Qi Wei, Hemant K. Tiwari, Josh F. Peterson, Wendy K. Chung, Brittney H. Davis, Atlas Khan, Leah C. Kottyan, Nita A. Limdi, QiPing Feng, Megan J. Puckelwartz, Chunhua Weng, Johanna L. Smith, Elizabeth W. Karlson, Regeneron Genetics Center, Gail P. Jarvik, Marylyn D. Ritchie   +20 more
openalex   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies

Alzheimer’s Research & Therapy
Background The success of selecting high risk or early-stage Alzheimer’s disease individuals for the delivery of clinical trials depends on the design and the appropriate recruitment of participants.
Eftychia Bellou, Woori Kim, Ganna Leonenko, Feifei Tao, Emily Simmonds, Ying Wu, Niklas Mattsson-Carlgren, Oskar Hansson, Michael W. Nagle, Valentina Escott-Price, the Alzheimer’s Disease Neuroimaging Initiative   +10 more
doaj   +1 more source