Results 181 to 190 of about 65,839 (347)
Exploring the genetic overlap between substance use disorder and educational attainment
Addiction, EarlyView.Abstract Background and aims
Substance use disorder (SUD) is a polygenic psychiatric condition characterized by persistent drug use despite negative consequences. Several studies support that higher cognitive performance and educational attainment (EA) are associated with a reduced risk for SUD.Judit Cabana‐Domínguez, Laura Vilar‐Ribó, María Soler Artigas, Silvia Alemany, Natalia Llonga, Pau Carabí‐Gassol, Uxue Zubizarreta‐Arruti, Valeria Macias‐Chimborazo, Lara Grau‐López, Constanza Daigre, Elena Ros‐Cucurull, Raúl Felipe Palma‐Alvarez, Germán Ortega‐Hernández, Noèlia Fernàndez‐Castillo, Bru Cormand, Josep Antoni Ramos‐Quiroga, Marta Ribasés +16 morewiley +1 more sourceMultiple polygenic score approach in colorectal cancer risk prediction
Scientific ReportsRecent studies have demonstrated that for various diseases, incorporating polygenic risk scores (PRSs) for other traits and diseases into the PRS-based risk prediction model may improve predictive performance – known as Multiple Polygenic Score (MPS ...Shangqing Joyce Jiang, Minta Thomas, Elisabeth A. Rosenthal, Amanda I. Phipps, Lori C. Sakoda, Franzel J. B. van Duijnhoven, Andrew J. Pellatt, Christy L. Avery, Sonja I. Berndt, D. Timothy Bishop, Sergi Castellví-Bel, Andrew T. Chan, Robert C. Grant, Chris Gignoux, Andrea Gsur, Marc J. Gunter, Christopher A. Haiman, Michael Hoffmeister, Gail P. Jarvik, Mark A. Jenkins, Temitope O. Keku, Sébastien Küry, Jeffrey K. Lee, Loic Le Marchand, Victor Moreno, Polly A. Newcomb, Christina C. Newton, Shuji Ogino, Julie R. Palmer, Rachel Pearlman, Conghui Qu, Robert E. Schoen, Caroline Y. Um, Bethany Van Guelpen, Kala Visvanathan, Veronika Vymetalkova, Emily White, Michael O. Woods, Elizabeth A. Platz, Hermann Brenner, Douglas A. Corley, Iris Landorp Vogelaar, Li Hsu, Ulrike Peters +43 moredoaj +1 more sourceAtopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics [PDF]
, 2023 Ali Al‐Janabi, Stephen Eyre, Amy Foulkes, Adnan R. Khan, Nick Dand, Ekaterina Burova, Bernadette DeSilva, Areti Makrygeorgou, Emily Davies, Catherine Smith, C.E.M. Griffiths, Andrew P. Morris, Richard B. Warren +12 moreopenalex +1 more sourceTrajectories of genetic risk across dimensions of alcohol use behaviors
Addiction, EarlyView.Abstract Background and aims
Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is usually not considered in research identifying and investigating the genes linked to AUBs ...Jeanne E. Savage, Fazil Aliev, Peter B. Barr, Maia Choi, Gabin Drouard, Megan E. Cooke, Sally I. Kuo, Mallory Stephenson, Sarah J. Brislin, Zoe E. Neale, Spit for Science Working Group, Karen Chartier, Ananda Amstadter, Danielle M. Dick, Emily Lilley, Renolda Gelzinis, Anne Morris, Katie Bountress, Amy E. Adkins, Nathaniel Thomas, Zoe Neale, Kimberly Pedersen, Thomas Bannard, Seung B. Cho, Peter Barr, Holly Byers, Erin C. Berenz, Erin Caraway, James S. Clifford, Megan Cooke, Elizabeth Do, Alexis C. Edwards, Neeru Goyal, Laura M. Hack, Lisa J. Halberstadt, Sage Hawn, Sally Kuo, Emily Lasko, Jennifer Lend, Mackenzie Lind, Elizabeth Long, Alexandra Martelli, Jacquelyn L. Meyers, Kerry Mitchell, Ashlee Moore, Arden Moscati, Aashir Nasim, Jill Opalesky, Cassie Overstreet, A. Christian Pais, Tarah Raldiris, Jessica Salvatore, Jeanne Savage, Rebecca Smith, David Sosnowski, Jinni Su, Chloe Walker, Marcie Walsh, Teresa Willoughby, Madison Woodroof, Jia Yan, Cuie Sun, Brandon Wormley, Brien Riley, Fazil Aliev, Roseann Peterson, Bradley T. Webb, COGA Investigators, Bernice Porjesz, Victor Hesselbrock, Arpana Agrawal, Danielle Dick, Howard J. Edenberg, Tatiana Foroud, Yunlong Liu, Martin H. Plawecki, Samuel Kuperman, Allan Anderson, Jacquelyn Meyers, Laura Bierut, Sarah Hartz, Marc Schuckit, Ronald Hart, Jay Tischfield, Laura Almasy, Alison Goate, Paul Slesinger, Denise Scott, Cathryn Holzhauer, Michie Hesselbrock, Dongbing Lai, John Nurnberger Jr., Leah Wetherill, Xiaoling Xuei, Sean O'Connor, John Kramer, Grace Chan, Chella Kamarajan, Ashwini Pandey, David B. Chorlian, Sivan Kinreich, Gayathri Pandey, Chris Chatzinakos, Jian Zhang, Stacey Saenz deViteri, Christian Richard, Arjun Bingly, Gita Pathak, Andrey Anokhin, Kathleen Bucholz, Fanghong Dong, Alexander Hatoum, Emma Johnson, Vivia McCutcheon, John Rice, Scott Saccone, Zhiping Pang, Sarah Brislin, Jennifer Moore, Alison Merikangas, Miri Gitik, Antti Latvala, Richard J. Rose, Jaakko Kaprio, Danielle M. Dick, Jacquelyn Meyers, Jessica E. Salvatore, Danielle Posthuma +127 morewiley +1 more sourceMediation of Polygenic Asthma Risk Through Gene Expression
Allergy, EarlyView.We apply published PRSs in African‐ancestry individuals and quantify the extent to which the PRS‐asthma relationship is mediated by clinical biomarkers and gene‐expression signatures of asthma. We found the best PRS to be the one derived using the largest sample size and including African‐ancestry individuals.Rakesh Natarajan, Brooke Szczesny, Kanika Kanchan, Erika Esquinca, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Wendy Lorizio, Ayo P. Doumatey, Alvaro A. Cruz, Harold Watson, Edward T. Naureckas, B. Louise Giles, Ganiyu Arinola, Olumide Sogaolu, Adegoke G. Falade, Nadia N. Hansel, Christopher O. Olopade, Charles N. Rotimi, R. Clive Landis, Camila A. Figueiredo, Eimear E. Kenny, Ingo Ruczinski, Andrew H. Liu, Carole Ober, Margaret A. Taub, Randi K. Johnson, Kathleen C. Barnes, Genevieve L. Wojcik, Rasika A. Mathias +29 morewiley +1 more source
