Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, EarlyView.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
Genetic architecture and polygenic risk score prediction of degenerative suspensory ligament desmitis (DSLD) in the Peruvian Horse [PDF]
, 2023 Mehdi Momen +9 more
openalex +1 more source
Andrology, EarlyView.Abstract Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier.
Manuela Simoni +2 more
wiley +1 more source
Prenatal antidepressant exposure and the risk of decreased gestational age and lower birthweight: A polygenic score approach to investigate confounding by indication [PDF]
, 2023 Anna‐Sophie Rommel +7 more
openalex +1 more source
Advances in the genetics of refractive errors: Contributions from the CREAM consortium
Acta Ophthalmologica, EarlyView.Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li +11 more
wiley +1 more source
Polygenic risk score-guided personalized osteoporosis screening: a population-based study. [PDF]
BMC MedWang D +6 more
europepmc +1 more source
Schizophrenia polygenic risk score and psychotic risk detection [PDF]
The Lancet Psychiatry, 2017 Michele, Poletti +2 more
openaire +2 more sources
Alimentary Pharmacology &Therapeutics, EarlyView.Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Lorenz Balcar +18 more
wiley +1 more source
Existentialism and My ‘Postwolf’ Dachshund: Authenticity in the Age of Genetic Engineering
Bioethics, EarlyView.ABSTRACT Human genetic engineering has the potential to profoundly alter the traits of future generations, raising critical ethical questions about authenticity and identity. Essentialist perspectives reject genetic engineering, claiming it inherently compromises authenticity by deviating from a species‐typical genome.
Donrich Thaldar
wiley +1 more source
Polygenic risk score predicts pathologically confirmed cerebral amyloid angiopathy. [PDF]
Alzheimers DementPyun JM +4 more
europepmc +1 more source