Results 221 to 230 of about 65,839 (347)

Supplemental Table S8 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage

Xiaosong Huang, Paul C. Lott, Donglei Hu, Valentina A. Zavala, Zoeb N. Jamal, Tatiana Vidaurre, Sandro Casavilca‐Zambrano, Jeannie Navarro Vásquez, Carlos A. Castañeda, Guillermo Valencia, Zaida Morante, Mónica Calderón, Julio E. Abugattas, Hugo Fuentes, Ruddy Liendo-Picoaga, José M. Cotrina, Silvia P. Neciosup, Patricia Rioja, Luis A. Salinas, Marco Gálvez-Niño, Scott Huntsman, Sixto E. Sánchez, Michelle A. Williams, Bizu Gelaye, Ana P. Estrada-Florez, Guadalupe Polanco‐Echeverry, Magdalena Echeverry, Alejandro Vélez Hoyos, Jenny A. Carmona-Valencia, Mábel Bohórquez, Javier Torres, Miguel Cruz, Weang-Kee Ho, Soo‐Hwang Teo, Mei-Chee Tai, Esther M. John, Christopher A. Haiman, David V. Conti, Fei Chen, Gabriela Torres-Mejı́a, Lawrence H. Kushi, Susan L. Neuhausen, Elad Ziv, Luis G. Carvajal‐Carmona, Laura Fejerman   +44 more
openalex   +1 more source

Genetic risk factor identification for common epilepsies guided by integrative omics data analysis

Epilepsia, EarlyView.
Abstract Objective Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to these epilepsies have been identified in the past decades, many features of the genetic architecture are ...
Ashwini Mushunuri, Oluyomi Adesoji, Roland Krause, Patrick May, Holger Lerche, Albert Becker, Daniela Grimm, International League Against Epilepsy Consortium on Complex Epilepsies, Michael Nothnagel, Herbert Schulz   +9 more
wiley   +1 more source

A review of methods and software for polygenic risk score analysis. [PDF]

PeerJ Comput Sci
Benoumhani S, Al-Wabil A, Imam N, Alfawaz B, Zubairi A, Aldossary D, AlEissa M.   +6 more
europepmc   +1 more source

Supplementary Figure 1 from Polygenic Risk Score Modifies Prostate Cancer Risk of Pathogenic Variants in Men of African Ancestry

, 2023
Raymond W. Hughley, Marco Matejcic, Ziwei Song, Xin Sheng, Peggy Wan, Lucy Xia, Steven N. Hart, Chunling Hu, Siddhartha Yadav, Alexander Lubmawa, Vicky Kiddu, Frank Asiimwe, Colline Amanya, George Mutema, Kuteesa Job, Mbaaga K. Ssebakumba, Sue A. Ingles, Ann S. Hamilton, Fergus J. Couch, Stephen Watya, David V. Conti, Burcu F. Darst, Christopher A. Haiman   +22 more
openalex   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

A machine learning-derived polygenic risk score reveals that healthy lifestyle counteracts obesity-related mortality. [PDF]

NPJ Digit Med
Xiao L, Liang S, Zeng L, Cai S, Wang J, Hong C, Li Y, Li R, Jiang P, Xie Z, Li T, Wu S, Liu L, Wu G, Lai W.   +14 more
europepmc   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Weighing the Genetic Risk: Associations Between Polygenic Risk Scores for Cardiometabolic Phenotypes and Adolescent Depression and Body Dissatisfaction

Krista M. Ekberg, Giorgia Michelini, Kristin L. Schneider, Anna R. Docherty, Andrey A. Shabalin, Greg Perlman, Roman Kotov, Daniel N. Klein, Monika A. Waszczuk   +8 more
openalex   +1 more source

Improving Melanoma Risk Stratification of Skin Color Type by Polygenic Scores of Skin Color and Melanoma

International Journal of Dermatology, EarlyView.
ABSTRACT Background The Fitzpatrick skin type (FST) is commonly used in clinical settings to stratify melanoma risk across different skin types. However, it is subjective and does not capture intra‐type variability in risk. These limitations are particularly evident among lighter‐skinned individuals, who constitute the majority of those with European ...
Huy Tran, Annabelle Ashworth, Zhuqing Shi, Jun Wei, S. Lilly Zheng, Ross M. Levy, Luzheng Liu, David Duggan, Aleksandar Sekulic, Jianfeng Xu   +9 more
wiley   +1 more source

Improving polygenic risk score based drug response prediction using transfer learning. [PDF]

NPJ Genom Med
Cheng Y, Zhai S, Zhong W, West RM, Shen J.   +4 more
europepmc   +1 more source