Polygenic Risk Scores Expand to Obesity [PDF]
Cell, 2019 Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity.
Ali, Torkamani, Eric, Topol
openaire +2 more sources
Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease
Translational Psychiatry, 2021 Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of ...
Hannah Stocker +10 more
doaj +1 more source
A Multitrait Polygenic Risk Score for Open-Angle Glaucoma Stratifies Risk of Pigmentary Glaucoma in Pigment Dispersion Syndrome. [PDF]
Ophthalmol GlaucomaKolovos A +31 more
europepmc +3 more sources
Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort [PDF]
, 2018 Background: There is strong evidence that people born in winter and in spring have a small increased risk of schizophrenia. As this ‘season of birth’ effect underpins some of the most influential hypotheses concerning potentially modifiable risk ...
Escott-Price, Valentina +7 more
core +3 more sources
Assessing thyroid cancer risk using polygenic risk scores [PDF]
Proceedings of the National Academy of Sciences, 2020 Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed the combined genetic effects of these variants on PTC risk by using summarized GWAS ...
Sandya Liyanarachchi +20 more
openaire +5 more sources
Polygenic risk score, healthy lifestyles, and risk of incident depression
Translational Psychiatry, 2021 Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of ...
Zhi Cao +6 more
doaj +1 more source
Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study and meta-analysis [PDF]
, 2015 IMPORTANCE Schizophrenia has a complex etiology influenced both by genetic and nongenetic factors but disentangling these factors is difficult. OBJECTIVE To estimate (1) how strongly the risk for schizophrenia relates to the mutual effect of the ...
Agerbo, Esben +12 more
core +2 more sources
Genome-wide association studies of the self-rating of effects of ethanol (SRE). [PDF]
, 2020 The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for
Agrawal, Arpana +23 more
core +2 more sources
Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease
Annals of Clinical and Translational Neurology, 2023 Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes from the National Institute on Aging Late‐Onset Alzheimer's Disease Family‐Based
Min Qiao +19 more
doaj +1 more source
Current Oncology, 2022 The development of new screening methods and diagnostic tests for traits, common diseases, and cancer is linked to the advent of precision genomic medicine, in which health care is individually adjusted based on a person’s lifestyle, environmental ...
Howard Lopes Ribeiro Junior +4 more
doaj +1 more source