Results 51 to 60 of about 613,789 (384)

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases

Frontiers in Immunology, 2022
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments.
Chachrit Khunsriraksakul, Chachrit Khunsriraksakul, Havell Markus, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, Dajiang J. Liu   +8 more
doaj   +1 more source

A polygenic risk score predicts atrial fibrillation in cardiovascular disease.

European Heart Journal, 2022
AIMS Interest in targeted screening programmes for atrial fibrillation (AF) has increased, yet the role of genetics in identifying patients at highest risk of developing AF is unclear.
N. Marston, Amanda C Garfinkel, Frederick K. Kamanu, G. Melloni, C. Roselli, P. Jarolím, D. Berg, Deepak L. Bhatt, Marc P. Bonaca, C. Cannon, R. Giugliano, M. O’Donoghue, I. Raz, B. Scirica, E. Braunwald, D. Morrow, P. Ellinor, S. Lubitz, M. Sabatine, C. Ruff   +19 more
semanticscholar   +1 more source

Polygenic risk scores in epilepsy

Medizinische Genetik, 2022
Abstract An epilepsy diagnosis has large consequences for an individual but is often difficult to make in clinical practice. Novel biomarkers are thus greatly needed. Here, we give an overview of how thousands of common genetic factors that increase the risk for epilepsy can be summarized as epilepsy polygenic risk scores (PRS).
openaire   +3 more sources

Polygenic Risk Score in Africa Population: Progress and challenges [PDF]

, 2021
Polygenic risk score (PRS) analysis is a powerful method been used to estimate an individual's genetic risk towards targeted traits. PRS analysis could be used to obtain evidence of a genetic effect beyond Genome-Wide Association Studies (GWAS) results i.e. when there are no significant markers.
arxiv   +1 more source

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts [PDF]

, 2020
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects.
Bakke, A.B. (Arnold B.), Barnes, K. (Kelly), Barr, R.G. (Graham), Bartz, TM, Bleecker, E.R. (E.), Brusselle, G.G. (Guy), Cho, M.H. (Michael), Crapo, R.O. (Robert), Demeo, D.L. (Dawn), Do, A.R., Dudbridge, F. (Frank), Gharib, S.A. (Sina), Gulsvik, A. (Amund), Guyatt, A.L., Hall, I.P. (Ian), Hansel, C.R.W. (Christian), Hobbs, B.D., Hokanson, J.E., John, C, Kim, WJ, Lahousse, L. (Lies), Li, X. (Xinna), Lynch, D., Manichaikul, A. (Ani), McGeachie, M.J., Meyers, DA, Moll, M., Obeidat, M. (Ma'en), Psaty, B.M. (Bruce), Rich, S.S. (Stephen), Sakornsakolpat, P., Shrine, N., Silverman, E.K. (Edwin), Tal-Singer, R., Tobin, M.D. (Martin), Wain, L., Washko, G.R., Weiss, ST, Wijnant, S.R.A., Won, S   +39 more
core   +3 more sources

Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.

Brain : a journal of neurology, 2022
Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the central nervous system.
Hengameh Shams, Xiaorong Shao, A. Santaniello, G. Kirkish, A. Harroud, Qin Ma, N. Isobe, C. Schaefer, J. McCauley, B. Cree, Alessandro Didonna, S. Baranzini, N. Patsopoulos, S. Hauser, L. Barcellos, R. Henry, J. Oksenberg   +16 more
semanticscholar   +1 more source

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet, Michael S. Hildebrand, James D. Mills, Gary P. Brennan, Tore Eid, Susan A. Masino, Vicky Whittemore, Laura Bindila, Kevin K. Wang, Manisha Patel, Piero Perucca, Christopher A. Reid   +11 more
wiley   +1 more source

Physical activity, polygenic risk score, and colorectal cancer risk

Cancer Medicine, 2023
Introduction Whether and to what extent the relationship between physical activity (PA) and colorectal cancer (CRC) differs according to CRC‐related genetic risk remains to be determined, and no studies to date have quantified how much genetically ...
Xuechen Chen, Feng Guo, Jenny Chang‐Claude, Michael Hoffmeister, Hermann Brenner   +4 more
doaj   +1 more source

Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods

Nature Communications, 2022
Polygenic risk scores (PRS) have been successfully developed for the prediction of human diseases and complex traits in the past years. For drug response prediction in randomized clinical trials, a common practice is to apply PRS built from a disease ...
Song Zhai, Hong Zhang, D. Mehrotra, Judong Shen   +3 more
semanticscholar   +1 more source

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source