Results 71 to 80 of about 65,839 (347)
Post‐GWAS Polygenic Risk Score: Utility and Challenges
JBMR Plus, 2020 Over the past decade, through genome‐wide association studies, more than 300 genetic variants have been identified to be associated with either BMD or fracture risk.
Tuan V Nguyen, John A Eisman
doaj +1 more source
Association Between Polygenic Risk Score and Risk of Myopia [PDF]
JAMA Ophthalmology, 2020 Myopia is a leading cause of untreatable visual impairment and is increasing in prevalence worldwide. Interventions for slowing childhood myopia progression have shown success in randomized clinical trials; hence, there is a need to identify which children would benefit most from treatment intervention.To examine whether genetic information alone can ...
Mojarrad, Neema Ghorbani +76 more
openaire +5 more sources
A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk
Advanced Science, EarlyView.A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan +12 more
wiley +1 more source
Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students [PDF]
, 2017 Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms ...
Adkins, Amy +16 more
core +2 more sources
Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis. [PDF]
, 2020 Background and aimsThe associations between low educational attainment and substance use disorders (SUDs) may be related to a common genetic vulnerability.
Agrawal, Arpana +18 more
core +2 more sources
Schizophrenia polygenic risk score in psychosis proneness
European Archives of Psychiatry and Clinical Neuroscience, 2023 AbstractSchizophrenia (SZ) is a complex disorder with a highly polygenic inheritance. It can be conceived as the extreme expression of a continuum of traits that are present in the general population often broadly referred to as schizotypy. However, it is still poorly understood how these traits overlap genetically with the disorder.
Patricia Mas-Bermejo +7 more
openaire +5 more sources
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Breast Cancer Research, 2021 Background Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of oncotherapies has resulted in ...
Lathan Liou +7 more
doaj +1 more source
Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease [PDF]
, 2023 Aaron W. Aday +4 more
openalex +1 more source
Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits
Advanced Science, EarlyView.A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao +8 more
wiley +1 more source