Interpreting polygenic score effects in sibling analysis [PDF]
PLoS ONE, 2021 Researchers often claim that sibling analysis can be used to separate causal genetic effects from the assortment of biases that contaminate most downstream genetic studies (e.g. polygenic score predictors).
Jason Fletcher +3 more
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Associations of perceived neighborhood factors and Alzheimer's disease polygenic score with cognition: Evidence from the Health and Retirement Study. [PDF]
PLoS ONEBackgroundWe examined the relationships between neighborhood characteristics, cumulative genetic risk for Alzheimer's disease (polygenic scores for Alzheimer's disease), and cognitive function using data from the Health and Retirement Study (2008-2020 ...
Erin B Ware +7 more
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PGSXplorer: an integrated nextflow pipeline for comprehensive quality control and polygenic score model development [PDF]
PeerJThe rapid development of next-generation sequencing technologies and genomic data sharing initiatives during the post-Human Genome Project-era has catalyzed major advances in individualized medicine research.
Tutku Yaraş +2 more
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A polygenic score method boosted by non-additive models [PDF]
Nature CommunicationsDominance heritability in complex traits has received increasing recognition. However, most polygenic score (PGS) approaches do not incorporate non-additive effects.
Rikifumi Ohta +4 more
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Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications
Frontiers in Neuroscience, 2021 The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
Xiaopu Zhou +9 more
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Evaluation of polygenic prediction methodology within a reference-standardized framework.
PLoS Genetics, 2021 The predictive utility of polygenic scores is increasing, and many polygenic scoring methods are available, but it is unclear which method performs best.
Oliver Pain +11 more
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Development of risk prediction models for depression combining genetic and early life risk factors
Frontiers in Neuroscience, 2023 BackgroundBoth genetic and early life risk factors play important roles in the pathogenesis and progression of adult depression. However, the interplay between these risk factors and their added value to risk prediction models have not been fully ...
Tianyuan Lu +6 more
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BMJ Medicine, 2023 Objective To clarify the performance of polygenic risk scores in population screening, individual risk prediction, and population risk stratification.Design Secondary analysis of data in the Polygenic Score Catalog.Setting Polygenic Score Catalog, April ...
Harry Hemingway +10 more
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BMC Medical Genomics, 2021 Background Polygenic scores—which quantify inherited risk by integrating information from many common sites of DNA variation—may enable a tailored approach to clinical medicine. However, alongside considerable enthusiasm, we and others have highlighted a
Deanna G. Brockman +13 more
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Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists
Frontiers in Genetics, 2022 A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister +2 more
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