Results 1 to 10 of about 3,197,012 (359)

Interpreting polygenic score effects in sibling analysis [PDF]

PLoS ONE, 2021
Researchers often claim that sibling analysis can be used to separate causal genetic effects from the assortment of biases that contaminate most downstream genetic studies (e.g. polygenic score predictors).
Jason Fletcher, Yuchang Wu, Tianchang Li, Qiongshi Lu   +3 more
doaj   +7 more sources

Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction

Communications Biology
Polygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction.
Hyein Jung, Hae-Un Jung, Eun Ju Baek, Shin Young Kwon, Ji-One Kang, Ji Eun Lim, Bermseok Oh   +6 more
doaj   +4 more sources

A polygenic score method boosted by non-additive models [PDF]

Nature Communications
Dominance heritability in complex traits has received increasing recognition. However, most polygenic score (PGS) approaches do not incorporate non-additive effects.
Rikifumi Ohta, Yosuke Tanigawa, Yuta Suzuki, Manolis Kellis, Shinichi Morishita   +4 more
doaj   +3 more sources

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog

BMJ Medicine, 2023
Objective To clarify the performance of polygenic risk scores in population screening, individual risk prediction, and population risk stratification.Design Secondary analysis of data in the Polygenic Score Catalog.Setting Polygenic Score Catalog, April ...
Harry Hemingway, Riyaz Patel, Joan K Morris, Aroon D Hingorani, Reecha Sofat, Claudia Langenberg, Nicholas J Wald, Valerie Kuan, Chris Finan, Jasmine Gratton, A Floriaan Schmidt   +10 more
doaj   +2 more sources

Design and user experience testing of a polygenic score report: a qualitative study of prospective users

BMC Medical Genomics, 2021
Background Polygenic scores—which quantify inherited risk by integrating information from many common sites of DNA variation—may enable a tailored approach to clinical medicine. However, alongside considerable enthusiasm, we and others have highlighted a
Deanna G. Brockman, Lia Petronio, Jacqueline S. Dron, Bum Chul Kwon, Trish Vosburg, Lisa Nip, Andrew Tang, Mary O’Reilly, Niall Lennon, Bang Wong, Kenney Ng, Katherine H. Huang, Akl C. Fahed, Amit V. Khera   +13 more
doaj   +2 more sources

Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications

Frontiers in Neuroscience, 2021
The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
Xiaopu Zhou, Xiaopu Zhou, Xiaopu Zhou, Yolanda Y. T. Li, Amy K. Y. Fu, Amy K. Y. Fu, Amy K. Y. Fu, Nancy Y. Ip, Nancy Y. Ip, Nancy Y. Ip   +9 more
doaj   +2 more sources

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia.
Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula   +6 more
doaj   +2 more sources

Polygenic Risk Score Prediction for Endometriosis [PDF]

Frontiers in Reproductive Health, 2021
Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen, Kirstine Kloeve-Mogensen, Palle Duun Rohde, Palle Duun Rohde, Simone Twisttmann, Marianne Nygaard, Kristina Magaard Koldby, Rudi Steffensen, Christian Møller Dahl, Dorte Rytter, Michael Toft Overgaard, Axel Forman, Lene Christiansen, Lene Christiansen, Mette Nyegaard, Mette Nyegaard   +15 more
doaj   +8 more sources

Three open questions in polygenic score portability [PDF]

Nature Communications
The broad adoption of polygenic scores (PGS) is hindered by their limited portability to people that differ—in genetic ancestry or other characteristics—from the GWAS samples used to construct them.
Joyce Y. Wang, Neeka Lin, Michael Zietz, Jason Mares, Olivia S. Smith, Paul J. Rathouz, Arbel Harpak   +6 more
doaj   +2 more sources

Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease. [PDF]

Eur Heart J
Background and Aims It is not clear how a polygenic risk score (PRS) can be best combined with guideline-recommended tools for cardiovascular disease (CVD) risk prediction, e.g. SCORE2.
Li L, Pang S, Starnecker F, Mueller-Myhsok B, Schunkert H.   +4 more
europepmc   +2 more sources