Results 101 to 110 of about 2,976,187 (391)
Assessment of genetic risk for improved clinical-neuropathological correlations
Acta Neuropathologica Communications, 2020 In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
Barbara E. Spencer +3 more
doaj +1 more source
Stroke, 2020 To the Editor: I read with great interest the article by Hachiya et al1 published in Stroke recently. Hachiya et al aimed to investigate the relationship between a genome-wide polygenic risk score and the development of ischemic stroke in a population ...
Bing-kun Zheng
semanticscholar +1 more source
JCPP Advances, Volume 2, Issue 4, December 2022., 2022 Abstract Readers of JCPP Advances known that the dominant classification system (Diagnostic and Statistical Manual of Mental Disorders) in psychiatry and psychology conceptualizes psychopathology as discrete diagnostic categories. This measurement model builds on a strong assumption of a clear discontinuity between individuals who meet criteria for a ...
Henrik Larsson, Erik Pettersson
wiley +1 more source
Clinical utility of polygenic scores for cardiometabolic disease in Arabs
Nature Communications, 2023 Arabs account for 5% of the world population and have a high burden of cardiometabolic disease, yet clinical utility of polygenic risk prediction in Arabs remains understudied. Among 5399 Arab patients, we optimize polygenic scores for 10 cardiometabolic
Injeong Shim +12 more
doaj +1 more source
Prospects for using risk scores in polygenic medicine [PDF]
Genome Medicine, 2017 Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric ...
Lewis, Cathryn M., Vassos, Evangelos
openaire +7 more sources
A comprehensive evaluation of polygenic score methods across cohorts in psychiatric disorders
medRxiv, 2020 Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted count of risk alleles identified in genome-wide association studies (GWASs).
Guiyan Ni +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang +11 more
wiley +1 more source
Incorporating External Risk Information with the Cox Model under Population Heterogeneity: Applications to Trans-Ancestry Polygenic Hazard Scores [PDF]
arXiv, 2023 Polygenic hazard score (PHS) models designed for European ancestry (EUR) individuals provide ample information regarding survival risk discrimination. Incorporating such information can improve the performance of risk discrimination in an internal small-sized non-EUR cohort.
arxiv
Mutation spectrum and polygenic score in German patients with familial hypercholesterolemia
Clinical Genetics, 2020 Autosomal‐dominant familial hypercholesterolemia (FH) is characterized by increased plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) and a substantial risk to develop cardiovascular disease.
L. Rieck +10 more
semanticscholar +1 more source
Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Brain : a journal of neurology, 2022 Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the central nervous system.
Hengameh Shams +16 more
semanticscholar +1 more source