Integrating Polygenic Scores into Multifactorial Breast Cancer Risk Assessment: Insights from the First Year of Clinical Implementation in Western Austria [PDF]
Lukas Forer +6 more
openalex +1 more source
Imputation and polygenic score performances of human genotyping arrays in diverse populations [PDF]
, 2022 Dat Nguyen +7 more
openalex +1 more source
Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis
Prenatal Diagnosis, EarlyView.ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell +6 more
wiley +1 more source
Characterisation of alcohol polygenic risk scores in the context of mental health outcomes: Within-individual and intergenerational analyses in the Avon Longitudinal Study of Parents and Children [PDF]
, 2020 Kayleigh Easey +7 more
openalex +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Agricultural production systems in the global North combine monocultures of specialised varieties and breeds with external interventions and inputs. Increasing the diversity of varieties, breeds and species may increase the system's resilience to external pressures through beneficial interactions.
Marinus J. M. Smulders +13 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long +7 more
wiley +1 more source
A flexible and parallelizable approach to genome‐wide polygenic risk scores [PDF]
, 2019 Paul J. Newcombe +3 more
openalex +1 more source
The clinical utility of the BMD-related comprehensive genome-wide polygenic score in identifying individuals with a high risk of osteoporotic fractures [PDF]
, 2023 Xiangxue Xiao, Qing Wu
openalex +1 more source
Pest Management Science, EarlyView.Microtitre plate assays of 286 Irish oat isolates show species‐specific azole sensitivity. In Fusarium langsethiae, mefentrifluconazole and tebuconazole sensitivities correlate, defining four phenotypes and supporting resistance monitoring and integrated control.
Diana E. Bucur, Steven Kildea
wiley +1 more source