Results 131 to 140 of about 2,929,620 (353)
Post‐GWAS Polygenic Risk Score: Utility and Challenges
JBMR Plus, 2020 Over the past decade, through genome‐wide association studies, more than 300 genetic variants have been identified to be associated with either BMD or fracture risk.
Tuan V Nguyen, John A Eisman
doaj +1 more source
Human-Precision Medicine Interaction: Public Perceptions of Polygenic Risk Score for Genetic Health Prediction [PDF]
Precision Medicine (PM) transforms the traditional "one-drug-fits-all" paradigm by customising treatments based on individual characteristics, and is an emerging topic for HCI research on digital health. A key element of PM, the Polygenic Risk Score (PRS), uses genetic data to predict an individual's disease risk.
arxiv +1 more source
Variability of polygenic prediction for body mass index in Africa
Genome MedicineBackground Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent ...
Tinashe Chikowore +11 more
doaj +1 more source
Effective Genetic Risk Prediction Using Mixed Models [PDF]
arXiv, 2014 To date, efforts to produce high-quality polygenic risk scores from genome-wide studies of common disease have focused on estimating and aggregating the effects of multiple SNPs. Here we propose a novel statistical approach for genetic risk prediction, based on random and mixed effects models.
arxiv
Contemporary Perspectives on Chronic Renal Disorders
Chronic Diseases and Translational Medicine, EarlyView.ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok +5 more
wiley +1 more source
Genome-wide polygenic score to predict chronic kidney disease across ancestries
Nature Network Boston, 2022 Atlas Khan +38 more
semanticscholar +1 more source
The Plant Genome, Volume 15, Issue 4, December 2022., 2022 Abstract Cocoa (Theobroma cacao L.) is the only tree that can produce cocoa. Cocoa beans are highly sought after by chocolate makers to produce chocolate. Cocoa can be fine aromatic, characterized by floral and fruity notes, or it can be described as standard cocoa with a more pronounced cocoa aroma and bitterness.
Kelly Colonges +18 more
wiley +1 more source
Polygenic risk scores: from research tools to clinical instruments
Genome Medicine, 2020 Genome-wide association studies have shown unequivocally that common complex disorders have a polygenic genetic architecture and have enabled researchers to identify genetic variants associated with diseases.
Cathryn M. Lewis, Evangelos Vassos
doaj +1 more source
Poly-Omic Prediction of Complex Traits: OmicKriging [PDF]
, 2013 High-confidence prediction of complex traits such as disease risk or drug response is an ultimate goal of personalized medicine. Although genome-wide association studies have discovered thousands of well-replicated polymorphisms associated with a broad spectrum of complex traits, the combined predictive power of these associations for any given trait ...
arxiv +1 more source
The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation
Nature Genetics, 2021 Samuel A. Lambert +12 more
semanticscholar +1 more source