Results 131 to 140 of about 3,197,012 (359)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

PRSice-2: Polygenic Risk Score software for biobank-scale data

GigaScience, 2019
Background Polygenic risk score (PRS) analyses have become an integral part of biomedical research, exploited to gain insights into shared aetiology among traits, to control for genomic profile in experimental studies, and to strengthen causal inference,
S. Choi, P. O’Reilly
semanticscholar   +1 more source

BridgePRS : A powerful trans-ancestry Polygenic Risk Score method [PDF]

, 2023
Clive Hoggart, Shing Wan Choi, Judit García‐González, Tade Souaiaia, Michael Preuß, Paul F. O’Reilly   +5 more
openalex   +1 more source

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. [PDF]

, 2019
Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders.
Andreassen, Ole A, Dale, Anders M, Djurovic, Srdjan, Fan, Chun Chieh, Frei, Oleksandr, Holland, Dominic, Maeland, Steffen, O'Connell, Kevin S, Shadrin, Alexey A, Smeland, Olav B, Thompson, Wesley K, Wang, Yunpeng   +11 more
core   +3 more sources

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort

International Journal of Cardiology. Cardiovascular Risk and Prevention
Introduction: The objective of this study was to examine the interplay of polygenic risk and individual lifestyle factors (and a composite score of lifestyle) as antecedents of CHD in a large multiethnic cohort.
Carlos Iribarren, Meng Lu, Martha Gulati, Nathan D. Wong, Roberto Elosua, Jamal S. Rana   +5 more
doaj   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts [PDF]

, 2017
Objective Bipolar disorder (BD) is one of the most heritable psychiatric conditions and is associated with high suicide risk. To explore the reasons for this link, this study examined the interaction between traumatic stress and BD polygenic risk ...
Benke, Kelly, Brucksch, Christine, Edenberg, Howard J., Fisher, Carrie, Frankland, Andrew, Fullerton, Janice M., Ghaziuddin, Neera, Glowinski, Anne L., Hulvershorn, Leslie A., Kamali, Masoud, Kastelic, Elizabeth, McInnis, Melvin G., Miller, Leslie, Mitchell, Philip B., Nurnberger, John I., Jr., Roberts, Gloria M. P., Shaw, Alex D., Stapp, Emma K., Toma, Claudio, Wilcox, Holly C.   +19 more
core   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population [PDF]

, 2015
Acknowledgements Generation Scotland has received core funding from the Chief Scientist Office of the Scottish Government Health Directorates CZD/16/6 and the Scottish Funding Council HR03006.
Clarke, T. K., Cox, S., Davies, G., Deary, I. J., Fernandez-Pujals, A. M., Hall, L. S., Hansell, N. K., Hayward, C., Hocking, L. J., Liewald, D. C., Lupton, M. K., MacIntyre, D. J., Martin, N. G., McIntosh, A. M., Medland, S. E., Montgomery, G. W., Padmanabhan, S., Pattie, A., Porteous, D. J., Smith, B. H., Starr, J., Thomson, P. A., Wright, M. J.   +22 more
core   +6 more sources

Variability of polygenic prediction for body mass index in Africa

Genome Medicine
Background Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent ...
Tinashe Chikowore, Kristi Läll, Lisa K. Micklesfield, Zane Lombard, Julia H. Goedecke, Segun Fatumo, Shane A. Norris, Reedik Magi, Michele Ramsay, Paul W. Franks, Guillaume Pare, Andrew P. Morris   +11 more
doaj   +1 more source