Results 151 to 160 of about 2,929,620 (353)

A Polygenic Score for Body Mass Index is Associated with Depressive Symptoms via Early Life Stress: Evidence for gene-environment correlation

bioRxiv, 2019
Background Increasing childhood overweight and obesity rates are associated with not only adverse physical, but also mental health outcomes, including depression.
Reut Avinun, A. Hariri
semanticscholar   +1 more source

Can artificial neural networks supplant the polygene risk score for risk prediction of complex disorders given very large sample sizes? [PDF]

arXiv, 2019
Genome-wide association studies (GWAS) provide a means of examining the common genetic variation underlying a range of traits and disorders. In addition, it is hoped that GWAS may provide a means of differentiating affected from unaffected individuals. This has potential applications in the area of risk prediction.
arxiv  

The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information

NeuroImage: Clinical, 2016
Genome-wise association studies have identified a number of common single-nucleotide polymorphisms (SNPs), each of small effect, associated with risk to bipolar disorder (BD).
Danai Dima, Simone de Jong, Gerome Breen, Sophia Frangou   +3 more
doaj   +1 more source

Multi-Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying.

JAMA psychiatry, 2019
Importance Exposure to bullying is a prevalent experience with adverse consequences throughout the life span. Individual vulnerabilities and traits, such as preexisting mental health problems, may be associated with increased likelihood of experiencing ...
T. Schoeler, S. Choi, F. Dudbridge, J. Baldwin, L. Duncan, C. Cecil, E. Walton, E. Viding, E. McCrory, J. Pingault   +9 more
semanticscholar   +1 more source

Proteome‐Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases

Advanced Genetics, EarlyView.
Here, causal relations are examined between 2940 plasma proteins and 19 cardiovascular diseases (CVD) using a human genetics‐based method. 218 proteins are found whose blood levels influence CVD risks, with about half being new discoveries and largely confirmed in an independent cohort.
Chen Li, Nicolas De Jay, Shan‐Shan Zhang, Xin Fang, Supriya Sharma, Katrina A. Catalano, Venkatesh Sridharan, Zhaoqing Wang, Lei Zhao, Joseph D. Szustakowski, Ching‐Pin Chang, Joseph C. Maranville, Emily R. Holzinger, Erika M. Kvikstad   +13 more
wiley   +1 more source

Patient Perspectives on Personalized Risk Communication Using Polygenic Risk Scores to Inform Colorectal Cancer Screening Decisions

AJPM Focus
Introduction: Colorectal cancer is increasingly diagnosed in people aged
Shauna R. Goldberg, MPH, Linda K. Ko, PhD, Li Hsu, PhD, Hang Yin, MS, Charles Kooperberg, PhD, Ulrike Peters, PhD, MPH, Andrea N. Burnett-Hartman, PhD, MPH   +6 more
doaj  

A Composite Multivariate Polygenic and Neuroimaging Score for Prediction of Conversion to Alzheimer's Disease [PDF]

, 2012
Roman Filipovych, Bilwaj Gaonkar, Christos Davatzikos   +2 more
openalex   +1 more source

The practice and promise of temporal genomics for measuring evolutionary responses to global change

Molecular Ecology Resources, EarlyView., 2023
Abstract Understanding the evolutionary consequences of anthropogenic change is imperative for estimating long‐term species resilience. While contemporary genomic data can provide us with important insights into recent demographic histories, investigating past change using present genomic data alone has limitations.
René D. Clark, Katrina A. Catalano, Kyra S. Fitz, Eric Garcia, Kyle E. Jaynes, Brendan N. Reid, Allyson Sawkins, Anthony A. Snead, John C. Whalen, Malin L. Pinsky   +9 more
wiley   +1 more source

The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk [PDF]

, 2013
Shaneda Warren Andersen, Amy Trentham‐Dietz, Ronald E. Gangnon, John M. Hampton, Jonine D. Figueroa, Halcyon G. Skinner, Corinne D. Engelman, Barbara E.K. Klein, Linda Titus, Polly A. Newcomb   +9 more
openalex   +1 more source

APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages

Aging Cell, Volume 21, Issue 12, December 2022., 2022
The APOE ɛ4 allele and minor alleles of rs2075650 TOMM40 and rs12721046 APOC1 variants confer a higher risk of Alzheimer's disease compared with the ɛ4 allele and no minor alleles of these two polymorphisms. Here, we show that the same relationship characterizes chances to live 85 years and older. Nevertheless, we show that Alzheimer's disease does not
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Eric Stallard, Mary F. Feitosa, Nicole Schupf, Kaare Christensen, Irina Culminskaya   +14 more
wiley   +1 more source