Results 151 to 160 of about 3,197,012 (359)

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Genome-wide polygenic score to predict chronic kidney disease across ancestries

Nature Medicine, 2022
Atlas Khan, M. Turchin, A. Patki, V. Srinivasasainagendra, N. Shang, R. Nadukuru, Alana C. Jones, E. Malolepsza, O. Dikilitas, I. Kullo, D. Schaid, E. Karlson, T. Ge, J. Meigs, J. Smoller, C. Lange, D. Crosslin, G. Jarvik, P. Bhatraju, J. Hellwege, P. Chandler, L. R. Torvik, A. Fedotov, Cong Liu, C. Kachulis, N. Lennon, N. Abul-Husn, Judy H. Cho, I. Ionita-Laza, A. Gharavi, Wendy K. Chung, G. Hripcsak, C. Weng, G. Nadkarni, M. Irvin, H. Tiwari, E. Kenny, N. Limdi, K. Kiryluk   +38 more
semanticscholar   +1 more source

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

Nature Genetics, 2021
Samuel A. Lambert, Laurent Gil, S. Jupp, S. Ritchie, Yu Xu, A. Buniello, A. McMahon, Gad Abraham, Michael Chapman, Helen Parkinson, J. Danesh, Jacqueline A. L. MacArthur, M. Inouye   +12 more
semanticscholar   +1 more source

Educational attainment polygenic scores, socioeconomic factors, and cortical structure in children and adolescents

, 2022
Emily C. Merz, Jordan Strack, Hailee Hurtado, Uku Vainik, Michael L. Thomas, Alan C. Evans, Budhachandra Khundrakpam   +6 more
openalex   +1 more source

Multi-polygenic score approach to trait prediction

Molecular Psychiatry, 2017
A primary goal of polygenic scores, which aggregate the effects of thousands of trait-associated DNA variants discovered in genome-wide association studies (GWASs), is to estimate individual-specific genetic propensities and predict outcomes.
Eva Krapohl, Hamel Patel, Hamel Patel, S. Newhouse, S. Newhouse, S. Newhouse, C. Curtis, S. V. Stumm, Philip S. Dale, D. Zabaneh, G. Breen, P. O’Reilly, R. Plomin   +12 more
semanticscholar   +1 more source

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. [PDF]

, 2019
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association ...
Aiello, Allison E, Almli, Lynn M, Amstadter, Ananda B, Andersen, Søren B, Andreassen, Ole A, Arbisi, Paul A, Ashley-Koch, Allison E, Atkinson, Elizabeth G, Austin, S Bryn, Avdibegovic, Esmina, Babić, Dragan, Baker, Dewleen G, Beckham, Jean C, Bierut, Laura J, Bisson, Jonathan I, Boks, Marco P, Bolger, Elizabeth A, Bradley, Bekh, Brashear, Megan, Breen, Gerome, Bryant, Richard A, Bustamante, Angela C, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Børglum, Anders D, Calabrese, Joseph R, Caldas-de-Almeida, José M, Chen, Chia-Yen, Choi, Karmel W, Coleman, Jonathan RI, Dale, Anders M, Dalvie, Shareefa, Daly, Mark J, Daskalakis, Nikolaos P, Deckert, Jürgen, Delahanty, Douglas L, Dennis, Michelle F, Disner, Seth G, Domschke, Katharina, Duncan, Laramie E, Dzubur-Kulenovic, Alma, Erbes, Christopher R, Evans, Alexandra, Farrer, Lindsay A, Feeny, Norah C, Flory, Janine D, Forbes, David, Franz, Carol E, Galea, Sandro, Garrett, Melanie E, Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles, Gordon, Scott D, Guffanti, Guia, Hammamieh, Rasha, Harnal, Supriya, Hauser, Michael A, Heath, Andrew C, Hemmings, Sian MJ, Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Junglen, Angela G, Karstoft, Karen-Inge, Kaufman, Milissa L, Kessler, Ronald C, Khan, Alaptagin, Kimbrel, Nathan A, King, Anthony P, Klengel, Torsten, Koen, Nastassja, Kranzler, Henry R, Kremen, William S, Lawford, Bruce R, Lebois, Lauren AM, Levey, Daniel F, Lewis, Catrin E, Linnstaedt, Sarah D, Logue, Mark W, Lori, Adriana, Lugonja, Bozo, Luykx, Jurjen J, Lyons, Michael J, Maihofer, Adam X, Maples-Keller, Jessica, Marmar, Charles, Martin, Alicia R, Nievergelt, Caroline M, Polimanti, Renato, Provost, Allison C, Qin, Xue-Jun, Ratanatharathorn, Andrew, Stein, Murray B, Torres, Katy, Uka, Aferdita Goci   +99 more
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Neurobiological correlates of obsessive‐compulsive disorder (OCD): A narrative review

Ibrain, EarlyView.
Obsessive‐compulsive disorder (OCD) is a common and disabling, as well as underdiagnosed, neuropsychiatric condition characterized by involuntary and unwanted obsessions and/or compulsions often accompanied by states of severe anxiety, distress and shame, as well as other comorbid disorders. Despite the extensive literature available to date, only some
Giulio Perrotta, Anna Sara Liberati
wiley   +1 more source

Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study

JAMA psychiatry, 2017
Importance Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking.
Azmeraw T. Amare, K. Schubert, L. Hou, S. Clark, S. Papiol, U. Heilbronner, F. Degenhardt, F. Tekola-Ayele, Y. Hsu, T. Shekhtman, M. Adli, N. Akula, K. Akiyama, R. Ardau, B. Arias, J. Aubry, L. Backlund, A. Bhattacharjee, F. Bellivier, A. Benabarre, S. Bengesser, J. Biernacka, A. Birner, C. Brichant‐Petitjean, P. Cervantes, Hsi-Chung Chen, C. Chillotti, S. Cichon, C. Cruceanu, P. Czerski, N. Dalkner, A. Dayer, M. Del Zompo, J. R. DePaulo, B. Étain, P. Falkai, A. Forstner, L. Frisén, M. Frye, J. Fullerton, S. Gard, J. Garnham, F. Goes, M. Grigoroiu-Serbanescu, P. Grof, R. Hashimoto, J. Hauser, S. Herms, P. Hoffmann, A. Hofmann, S. Jamain, E. Jiménez, J. Kahn, L. Kassem, Po-Hsiu Kuo, Tadafumi Kato, J. Kelsoe, S. Kittel-Schneider, S. Kliwicki, B. König, I. Kusumi, G. Laje, M. Landén, C. Lavebratt, M. Leboyer, S. Leckband, A. Tortorella, M. Manchia, Lina Martinsson, M. McCarthy, S. McElroy, F. Colom, M. Mitjans, Francis M. Mondimore, P. Monteleone, C. Nievergelt, M. Nöthen, T. Novák, C. O’Donovan, N. Ozaki, U. Ösby, A. Pfennig, J. Potash, A. Reif, E. Reininghaus, G. Rouleau, J. Rybakowski, M. Schalling, P. Schofield, Barbara W. Schweizer, G. Severino, P. Shilling, Katzutaka Shimoda, C. Simhandl, C. Slaney, A. Squassina, T. Stamm, P. Stopková, M. Maj, G. Turecki, E. Vieta, J. Volkert, S. Witt, Adam Wright, P. Zandi, P. Mitchell, M. Bauer, M. Alda, M. Rietschel, F. McMahon, T. Schulze, B. Baune   +111 more
semanticscholar   +1 more source

Supplementary Figure 1 from Polygenic Risk Score Modifies Prostate Cancer Risk of Pathogenic Variants in Men of African Ancestry

, 2023
Raymond W. Hughley, Marco Matejcic, Ziwei Song, Xin Sheng, Peggy Wan, Lucy Xia, Steven N. Hart, Chunling Hu, Siddhartha Yadav, Alexander Lubmawa, Vicky Kiddu, Frank Asiimwe, Colline Amanya, George Mutema, Kuteesa Job, Mbaaga K. Ssebakumba, Sue A. Ingles, Ann S. Hamilton, Fergus J. Couch, Stephen Watya, David V. Conti, Burcu F. Darst, Christopher A. Haiman   +22 more
openalex   +1 more source

The many roads to psychosis: recent advances in understanding risk and mechanisms. [PDF]

, 2018
Schizophrenia is a chronic and severe mental illness which frequently leads to substantial lifelong disability. The past five years have seen major progress in our understanding of the complex genetic architecture of this disorder.
Bearden, Carrie E, Forsyth, Jennifer K
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