Results 151 to 160 of about 40,214 (287)
Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes [PDF]
, 2023 Justin D. Tubbs, Perry B.M. Leung, Yuanxin Zhong, Na Zhan, Tomy C.K. Hui, Karen K. Y. Ho, Karen S. Y. Hung, Eric F. C. Cheung, Hon‐Cheong So, Simon S. Y. Lui, Pak C. Sham +10 moreopenalex +1 more sourceExploring the genetic overlap between substance use disorder and educational attainment
Addiction, EarlyView.Abstract Background and aims
Substance use disorder (SUD) is a polygenic psychiatric condition characterized by persistent drug use despite negative consequences. Several studies support that higher cognitive performance and educational attainment (EA) are associated with a reduced risk for SUD.Judit Cabana‐Domínguez, Laura Vilar‐Ribó, María Soler Artigas, Silvia Alemany, Natalia Llonga, Pau Carabí‐Gassol, Uxue Zubizarreta‐Arruti, Valeria Macias‐Chimborazo, Lara Grau‐López, Constanza Daigre, Elena Ros‐Cucurull, Raúl Felipe Palma‐Alvarez, Germán Ortega‐Hernández, Noèlia Fernàndez‐Castillo, Bru Cormand, Josep Antoni Ramos‐Quiroga, Marta Ribasés +16 morewiley +1 more sourceTrajectories of genetic risk across dimensions of alcohol use behaviors
Addiction, EarlyView.Abstract Background and aims
Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is usually not considered in research identifying and investigating the genes linked to AUBs ...Jeanne E. Savage, Fazil Aliev, Peter B. Barr, Maia Choi, Gabin Drouard, Megan E. Cooke, Sally I. Kuo, Mallory Stephenson, Sarah J. Brislin, Zoe E. Neale, Spit for Science Working Group, Karen Chartier, Ananda Amstadter, Danielle M. Dick, Emily Lilley, Renolda Gelzinis, Anne Morris, Katie Bountress, Amy E. Adkins, Nathaniel Thomas, Zoe Neale, Kimberly Pedersen, Thomas Bannard, Seung B. Cho, Peter Barr, Holly Byers, Erin C. Berenz, Erin Caraway, James S. Clifford, Megan Cooke, Elizabeth Do, Alexis C. Edwards, Neeru Goyal, Laura M. Hack, Lisa J. Halberstadt, Sage Hawn, Sally Kuo, Emily Lasko, Jennifer Lend, Mackenzie Lind, Elizabeth Long, Alexandra Martelli, Jacquelyn L. Meyers, Kerry Mitchell, Ashlee Moore, Arden Moscati, Aashir Nasim, Jill Opalesky, Cassie Overstreet, A. Christian Pais, Tarah Raldiris, Jessica Salvatore, Jeanne Savage, Rebecca Smith, David Sosnowski, Jinni Su, Chloe Walker, Marcie Walsh, Teresa Willoughby, Madison Woodroof, Jia Yan, Cuie Sun, Brandon Wormley, Brien Riley, Fazil Aliev, Roseann Peterson, Bradley T. Webb, COGA Investigators, Bernice Porjesz, Victor Hesselbrock, Arpana Agrawal, Danielle Dick, Howard J. Edenberg, Tatiana Foroud, Yunlong Liu, Martin H. Plawecki, Samuel Kuperman, Allan Anderson, Jacquelyn Meyers, Laura Bierut, Sarah Hartz, Marc Schuckit, Ronald Hart, Jay Tischfield, Laura Almasy, Alison Goate, Paul Slesinger, Denise Scott, Cathryn Holzhauer, Michie Hesselbrock, Dongbing Lai, John Nurnberger Jr., Leah Wetherill, Xiaoling Xuei, Sean O'Connor, John Kramer, Grace Chan, Chella Kamarajan, Ashwini Pandey, David B. Chorlian, Sivan Kinreich, Gayathri Pandey, Chris Chatzinakos, Jian Zhang, Stacey Saenz deViteri, Christian Richard, Arjun Bingly, Gita Pathak, Andrey Anokhin, Kathleen Bucholz, Fanghong Dong, Alexander Hatoum, Emma Johnson, Vivia McCutcheon, John Rice, Scott Saccone, Zhiping Pang, Sarah Brislin, Jennifer Moore, Alison Merikangas, Miri Gitik, Antti Latvala, Richard J. Rose, Jaakko Kaprio, Danielle M. Dick, Jacquelyn Meyers, Jessica E. Salvatore, Danielle Posthuma +127 morewiley +1 more sourceMediation of Polygenic Asthma Risk Through Gene Expression
Allergy, EarlyView.We apply published PRSs in African‐ancestry individuals and quantify the extent to which the PRS‐asthma relationship is mediated by clinical biomarkers and gene‐expression signatures of asthma. We found the best PRS to be the one derived using the largest sample size and including African‐ancestry individuals.Rakesh Natarajan, Brooke Szczesny, Kanika Kanchan, Erika Esquinca, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Wendy Lorizio, Ayo P. Doumatey, Alvaro A. Cruz, Harold Watson, Edward T. Naureckas, B. Louise Giles, Ganiyu Arinola, Olumide Sogaolu, Adegoke G. Falade, Nadia N. Hansel, Christopher O. Olopade, Charles N. Rotimi, R. Clive Landis, Camila A. Figueiredo, Eimear E. Kenny, Ingo Ruczinski, Andrew H. Liu, Carole Ober, Margaret A. Taub, Randi K. Johnson, Kathleen C. Barnes, Genevieve L. Wojcik, Rasika A. Mathias +29 morewiley +1 more sourceKisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, EarlyView.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara +5 morewiley +1 more sourceDevelopment and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score. [PDF]
DiabetesDeutsch AJ, Bell AS, Michalek DA, Burkholder AB, Nam S, Kreienkamp RJ, Sharp SA, Huerta-Chagoya A, Mandla R, Nanjala R, Luo Y, Oram RA, Florez JC, Onengut-Gumuscu S, Rich SS, Ng MCY, Motsinger-Reif AA, Manning AK, Mercader JM, Udler MS. +19 moreeuropepmc +1 more sourceThe influence of polygenic risk scores on heritability of anti-CCP level in RA
, 2014 Jing Cui, Kimberly E. Taylor, Yvonne Lee, Henrik Källberg, Michael E. Weinblatt, Jonathan S. Coblyn, Lars Klareskog, Lindsey A. Criswell, Peter K. Gregersen, Nancy A. Shadick, Robert M. Plenge, Elizabeth W. Karlson +11 moreopenalex +2 more sources
