Results 161 to 170 of about 3,197,012 (359)

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago   +3 more
wiley   +1 more source

Distinct Polygenic Score Profiles in Schizophrenia Subgroups With Different Trajectories of Cognitive Development.

open access: yesAmerican Journal of Psychiatry, 2019
OBJECTIVE Different cognitive development histories in schizophrenia may reflect variation across dimensions of genetic influence. The authors derived and characterized cognitive development trajectory subgroups within a schizophrenia sample and profiled
D. Dickinson   +5 more
semanticscholar   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer   +11 more
wiley   +1 more source

A Polygenic Score for Body Mass Index is Associated with Depressive Symptoms via Early Life Stress: Evidence for gene-environment correlation

open access: yesbioRxiv, 2019
Background Increasing childhood overweight and obesity rates are associated with not only adverse physical, but also mental health outcomes, including depression.
Reut Avinun, A. Hariri
semanticscholar   +1 more source

Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease [PDF]

open access: green, 2023
Aaron W. Aday   +4 more
openalex   +1 more source

Polygenic scores, polygenic selection and spatial autocorrelation

open access: yes, 2017
Tests of polygenic selection are performed using GWAS hits and an empirical simulation with random ...
openaire   +1 more source

Challenges in the future of cancer screening

open access: yesInternational Journal of Cancer, EarlyView.
Abstract The purpose of cancer screening is to reduce mortality, and ideally incidence, from the cancer screened for. Until recently, cancer screening has been offered to all persons in pre‐defined sex‐ and age‐groups. The exception is lung screening which is targeted to high‐risk individuals.
Elsebeth Lynge   +29 more
wiley   +1 more source

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