Results 161 to 170 of about 2,929,620 (353)

Data Sharing in the PRIMED Consortium: Design, implementation, and recommendations for future policymaking [PDF]

open access: yesarXiv
Sharing diverse genomic and other biomedical datasets is critical to advance scientific discoveries and their equitable translation to improve human health. However, data sharing remains challenging in the context of legacy datasets, evolving policies, multi-institutional consortium science, and international stakeholders. The NIH-funded Polygenic Risk
arxiv  

All‐cause and liver‐related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank

open access: yesAlcoholism: Clinical and Experimental Research, Volume 46, Issue 12, Page 2245-2257, December 2022., 2022
High alcohol intake increases mortality but little is known about risk factors which affect mortality in high‐risk drinkers. We assessed 6640 UKB participants reporting >80g/50g (men/women) alcohol per day. Alcohol use disorders, diagnosis of liver disease, abnormal liver function tests and erythrocyte morphology predicted higher risk of death overall,
John B. Whitfield   +40 more
wiley   +1 more source

On genetic correlation estimation with summary statistics from genome-wide association studies [PDF]

open access: yesarXiv, 2019
Genome-wide association studies (GWAS) have been widely used to examine the association between single nucleotide polymorphisms (SNPs) and complex traits, where both the sample size n and the number of SNPs p can be very large. Recently, cross-trait polygenic risk score (PRS) method has gained extremely popular for assessing genetic correlation of ...
arxiv  

A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.

open access: yesBiological Psychiatry, 2021
G. Ni   +448 more
semanticscholar   +1 more source

Using polygenic scores in combination with symptom rating scales to identify attention-deficit/hyperactivity disorder

open access: yesBMC Psychiatry
Background The inclusion of biomarkers could improve diagnostic accuracy of attention-deficit/hyperactivity disorder (ADHD). One potential biomarker is the ADHD polygenic score (PGS), a measure of genetic liability for ADHD.
André Høberg   +3 more
doaj   +1 more source

PRSice: Polygenic Risk Score software [PDF]

open access: hybrid, 2014
Jack Euesden   +2 more
openalex   +1 more source

Polygenic risk scores and rheumatic diseases

open access: yesChinese Medical Journal, 2021
Matthew A. Brown, Zhixiu Li, Li-Shao Guo
openaire   +5 more sources

Racing toward the future of chronic hepatitis B management: Achieving functional cure and enhancing hepatocellular carcinoma surveillance through precision medicine

open access: yesInterdisciplinary Medicine, EarlyView.
Novel biomarker emergence plays a critical role in improving CHB management. Advances in sensitive detection methods, AI, and large‐scale data platforms have independently contributed to biomarkers while driving the development of multi‐omics approaches.
Yaru Shi, Rong Fan
wiley   +1 more source

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