Results 41 to 50 of about 40,214 (287)
Geographic Clustering of Polygenic Scores at Different Stages of the Life Course
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018 We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent’s state of birth with corresponding phenotypes. The polygenic scores for height and
Benjamin W. Domingue +3 more
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Communications Biology, 2022 The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.
Madeline L. Page +8 more
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Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.
PLoS Genetics, 2022 For Alzheimer's disease-a leading cause of dementia and global morbidity-improved identification of presymptomatic high-risk individuals and identification of new circulating biomarkers are key public health needs.
Manish D Paranjpe +15 more
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Life, 2020 Background: The monogenic defect in familial hypercholesterolemia (FH) is detected in ∼40% of cases. The majority of mutation-negative patients have a polygenic cause of high LDL-cholesterol (LDL-C).
Agnieszka Mickiewicz +11 more
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Translational Psychiatry, 2021 Changes in immune function are associated with variance in cognitive functioning in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we examined whether schizophrenia risk-associated microglial genes (measured via ...
Emma Corley +5 more
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Polygenic transcriptome risk scores improve portability of polygenic risk scores across ancestries [PDF]
, 2020 AbstractPolygenic risk scores (PRS) are on course to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry, meaning that the utility of PRS for non-European populations is limited because SNP effects and LD patterns may not be conserved across ...
Yanyu Liang +6 more
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Polygenic Risk Scores Expand to Obesity [PDF]
Cell, 2019 Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity.
Ali, Torkamani, Eric, Topol
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Polygenic Scores for Height in Admixed Populations [PDF]
G3 Genes|Genomes|Genetics, 2020 Abstract Polygenic risk scores (PRS) use the results of genome-wide association studies (GWAS) to predict quantitative phenotypes or disease risk at an individual level, and provide a potential route to the use of genetic data in personalized medical care.
Bitarello, Bárbara D., Mathieson, Iain
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Assessment of genetic risk for improved clinical-neuropathological correlations
Acta Neuropathologica Communications, 2020 In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
Barbara E. Spencer +3 more
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Performance of polygenic scores for predicting phobic anxiety. [PDF]
PLoS ONE, 2013 Anxiety disorders are common, with a lifetime prevalence of 20% in the U.S., and are responsible for substantial burdens of disability, missed work days and health care utilization.
Stefan Walter +9 more
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