Results 51 to 60 of about 2,929,620 (353)
Can education be personalised using pupils’ genetic data?
eLife, 2020 The increasing predictive power of polygenic scores for education has led to their promotion by some as a potential tool for genetically informed policy. How accurately polygenic scores predict an individual pupil's educational performance conditional on
Tim T Morris +2 more
doaj +1 more source
Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences [PDF]
Evolution, Medicine, and Public Health, 2018 Abstract Recent analyses of polygenic scores have opened new discussions concerning the genetic basis and evolutionary significance of differences among populations in distributions of phenotypes. Here, we highlight limitations in research on polygenic scores, polygenic adaptation and population differences.
Noah A. Rosenberg +4 more
openaire +3 more sources
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet +11 more
wiley +1 more source
Nature Communications, 2020 Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a genetic basis.
Davide Marnetto +9 more
semanticscholar +1 more source
Polygenic Risk Scores Expand to Obesity [PDF]
Cell, 2019 Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity.
Ali Torkamani, Eric J. Topol
openaire +3 more sources
Understanding polygenic models, their development and the potential application of polygenic scores in healthcare [PDF]
Journal of Medical Genetics, 2020 The use of genomic information to better understand and prevent common complex diseases has been an ongoing goal of genetic research. Over the past few years, research in this area has proliferated with several proposed methods of generating polygenic scores.
Babb De Villiers, Chantal +2 more
openaire +3 more sources
Epilepsia Open, EarlyView., 2022 Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza +7 more
wiley +1 more source
Evolution Letters, Volume 6, Issue 6, Page 460-473, December 2022., 2022 Abstract Plants have evolved diverse reproductive allocation strategies and seed traits to aid in dispersal, persistence in the seed bank, and establishment. In particular, seed size, dormancy, and early seedling vigor are thought to be key functional traits with important recruitment and fitness consequences across abiotic stress gradients.
Samsad Razzaque, Thomas E. Juenger
wiley +1 more source
BMC Medical Genomics, 2020 Background Polygenic scores are a strategy to aggregate the small, additive effects of single nucleotide polymorphisms across the genome. With phenotypes like Alzheimer’s disease, which have a strong and well-established genomic locus (APOE), the ...
Erin B. Ware +3 more
doaj +1 more source
Communications Biology, 2022 The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.
Madeline L. Page +8 more
doaj +1 more source