Results 71 to 80 of about 21,037 (206)

Enhanced Molecular Mobility of Ordinarily Structured Regions Drives Polyglutamine Disease*

Journal of Biological Chemistry, 2015
Background: Polyglutamine tract expansion within disease-associated proteins leads to protein aggregation and disease. Results: Molecular mobility of a single α-helix within ataxin-3 positively scales with polyglutamine tract length and drives misfolding
C. Lupton, D. Steer, P. Wintrode, S. Bottomley, Victoria A. Hughes, A. Ellisdon   +5 more
semanticscholar   +1 more source

The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation*

Journal of Biological Chemistry, 2015
Background: The Dictyostelium proteome is predicted to encode a vast amount of homopolymeric amino acid tracts, including long polyglutamine tracts. Results: Proteins with long polyglutamine tracts are soluble in Dictyostelium.
Stephanie Santarriaga, A. Petersen, K. Ndukwe, A. Brandt, N. Gerges, Jamie Bruns Scaglione, K. Scaglione   +6 more
semanticscholar   +1 more source

Adenovirus-mediated expression of mutant DRPLA proteins with expanded polyglutamine stretches in neuronally differentiated PC12 cells. Preferential intranuclear aggregate formation and apoptosis [PDF]

, 1999
Toshiya Sato
openalex   +1 more source

Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis*

Journal of Biological Chemistry, 2015
Background: Polyglutamine-expanded androgen receptor forms nuclear inclusions of cleaved AR. Results: Soluble aggregates and insoluble inclusions of polyglutamine-expanded AR contain full-length AR, which becomes proteolyzed by the proteasome within ...
E. Heine, Tamar R Berger, A. Pluciennik, C. Orr, Lori Zboray, D. Merry   +5 more
semanticscholar   +1 more source

Evidence for Proteasome Involvement in Polyglutamine Disease: Localization to Nuclear Inclusions in SCA3/MJD and Suppression of Polyglutamine Aggregation in vitro [PDF]

, 1999
Y. Chai, Stacia L. Koppenhafer, S. J. Shoesmith, Matthew K. Perez, Henry L. Paulson   +4 more
openalex   +1 more source

Pathogenesis of SCA3 and implications for other polyglutamine diseases

Neurobiology of Disease, 2020
Hayley S. McLoughlin, Lauren R. Moore, H. Paulson   +2 more
semanticscholar   +1 more source

A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster [PDF]

, 1999
Nancy M. Bonini
openalex   +1 more source

Neurodegeration based on polyglutamine aggregation

Rinsho Shinkeigaku, 2011
One of the major hypotheses about polyQ toxicity is the sequestration of functionally important proteins into the aggregates. We established and carried out a direct, systematic proteomic analysis of aggregate-interacting proteins (AIPs). This analysis, as well as other studies in our lab, has revealed the following AIPs in addition to our previously ...
openaire   +3 more sources

Cytoplasmic Localization and the Choice of Ligand Determine Aggregate Formation by Androgen Receptor with Amplified Polyglutamine Stretch [PDF]

, 2000
Matthias Becker, Elke Martin, Jean Schneikert, Harald F. Krug, Andrew C.B. Cato   +4 more
openalex   +1 more source

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila [PDF]

, 2000
Ho Yin Edwin Chan, John M. Warrick, Gladys L. Gray-Board, Henry L. Paulson, Nancy M. Bonini   +4 more
openalex   +1 more source