Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants
Advanced Science, Volume 13, Issue 27, 13 May 2026.The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley +1 more source
Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease
Scientific ReportsDendrite defects and loss are early cellular alterations observed across neurodegenerative diseases that play a role in early disease pathogenesis.
Sydney E. Prange +9 more
doaj +1 more source
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. [PDF]
, 2014 Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise when dysregulated.
Batlevi, Yakup +11 more
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Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]
, 2008 Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano +8 more
core +3 more sources
Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment
Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.ABSTRACT Single‐cell mechanical properties such as stiffness, elasticity, and viscosity, are crucial in governing biological processes like migration, proliferation, and differentiation. In cancer, the mechanical properties of cells undergo significant alterations, which contribute to tumor growth, metastasis, and resistance to therapy.
Merve Sevgi +7 more
wiley +1 more source
Quality control of protein import into mammalian mitochondria
Protein Science, Volume 35, Issue 5, May 2026.Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein +2 more
wiley +1 more source
RNA therapy for polyglutamine neurodegenerative diseases
Expert Reviews in Molecular Medicine, 2012 Polyglutamine neurodegenerative diseases result from the expansion of a trinucleotide CAG repeat, encoding a polyglutamine tract in the disease-causing protein. The process by which each polyglutamine protein exerts its toxicity is complex, involving a variety of mechanisms including transcriptional dysregulation, proteasome impairment and ...
Watson, L, Wood, M
openaire +3 more sources
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans [PDF]
, 2019 Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose
daeeun jeong +5 more
core +1 more source
Mitochondria and the Actin Cytoskeleton in Neurodegeneration
Cytoskeleton, Volume 83, Issue 4, Page 200-210, April 2026.ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli +3 more
wiley +1 more source
Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT [PDF]
, 2020 Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates.
Agrawal, Namita +10 more
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