Results 61 to 70 of about 11,293 (160)
Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila. [PDF]
PLoS Biology, 2008 The expansion of polyglutamine tracts in a variety of proteins causes devastating, dominantly inherited neurodegenerative diseases, including six forms of spinal cerebellar ataxia (SCA).
Derek Lessing, Nancy M Bonini
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Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
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Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
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Nanodiamond Quantum Sensors for Probing Free Radical Biology
Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
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Impaired GAPDH‐induced mitophagy contributes to the pathology of Huntington's disease
EMBO Molecular Medicine, 2015 Mitochondrial dysfunction is implicated in multiple neurodegenerative diseases. In order to maintain a healthy population of functional mitochondria in cells, defective mitochondria must be properly eliminated by lysosomal machinery in a process referred
Sunhee Hwang +2 more
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Aggregate, Volume 7, Issue 6, June 2026.This review surveys recent advances in light‐controlled peptide self‐assembly for the design of smart soft matter. It summarizes the underlying physicochemical principles, including thermodynamic control for reshaping free‐energy landscapes, and nonequilibrium control to produce kinetically trapped states and dissipative structures.
Lidong Chen +7 more
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The Effect of Protein Tagging on Aggregation and Phase Separation
Journal of Cellular Biochemistry, Volume 127, Issue 6, June 2026.ABSTRACT Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self‐assembly. This interference is particularly significant for intrinsically disordered proteins and low‐complexity domains, whose aggregation and phase separation are mediated by weak multivalent interactions that ...
Harunobu Saito, Kenji Sugase
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Autophagy is dysregulated in spinocerebellar ataxia type 2
Autophagy Reports, 2022 The accumulation of misfolded proteins and fibrillar aggregates inside neurons is a hallmark of several neurodegenerative diseases. While the exact role of these aggregates is still controversial, they are part of a cascade of molecular events that ...
Adriana Marcelo +2 more
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Huntingtin as an Actin Organizer: Structural and Functional Insights
Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
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The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao +7 more
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