Results 61 to 70 of about 11,319 (157)
Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila. [PDF]
PLoS Biology, 2008 The expansion of polyglutamine tracts in a variety of proteins causes devastating, dominantly inherited neurodegenerative diseases, including six forms of spinal cerebellar ataxia (SCA).
Derek Lessing, Nancy M Bonini
doaj +1 more source
ChemistryOpen, Volume 15, Issue 9, September 2026.Neurological disorders (NDs) are characterized by substantial loss of specific neurons, with Alzheimer's and Parkinson's diseases being the most frequent NDs and nearly 99% of all “foreign substances” are prohibited from entering the brain by the blood‐brain barrier (BBB) and the blood‐cerebrospinal fluid barrier (CFB).
Nnamdi Ikemefuna Okafor +3 more
wiley +1 more source
Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Current Challenges of Transcription Compartmentalization Research
Advanced Science, Volume 13, Issue 46, 17 August 2026.Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley +1 more source
Impaired GAPDH‐induced mitophagy contributes to the pathology of Huntington's disease
EMBO Molecular Medicine, 2015 Mitochondrial dysfunction is implicated in multiple neurodegenerative diseases. In order to maintain a healthy population of functional mitochondria in cells, defective mitochondria must be properly eliminated by lysosomal machinery in a process referred
Sunhee Hwang +2 more
doaj +1 more source
Huntingtin as an Actin Organizer: Structural and Functional Insights
Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
wiley +1 more source
Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality
Protein Science, Volume 35, Issue 8, August 2026.Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert +2 more
wiley +1 more source
Acta Crystallographica Section D, Volume 82, Issue 8, Page 940-946, August 2026.In biological systems, hydrogels often arise through liquid–liquid phase separation, where biomolecular condensates can age into gel‐like states. SAXS is a key technique to probe the molecular organization of these samples. This study introduces an in‐vacuum Gel‐Cell for SAXS‐based structural analysis of a biologically derived hydrogel formed by the ...
Stephanie Hutin +5 more
wiley +1 more source
Autophagy is dysregulated in spinocerebellar ataxia type 2
Autophagy Reports, 2022 The accumulation of misfolded proteins and fibrillar aggregates inside neurons is a hallmark of several neurodegenerative diseases. While the exact role of these aggregates is still controversial, they are part of a cascade of molecular events that ...
Adriana Marcelo +2 more
doaj +1 more source