Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation
BMC Cell Biology, 2007 Background Protein aggregation is a hallmark of several neurodegenerative diseases including Huntington's disease and Parkinson's disease. Proteins containing long, homopolymeric stretches of glutamine are especially prone to form aggregates. It has long
Caldwell Guy A +7 more
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Polyglutamine disease and neuronal cell death
Proceedings of the National Academy of Sciences, 2000 Research in the past decade has uncovered a new class of inherited neurodegenerative diseases, the polyglutamine (polyQ) expansion diseases (1). In each, the underlying mutation is an expansion of a CAG trinucleotide repeat that encodes polyQ in the respective disease proteins (Table 1).
H L, Paulson, N M, Bonini, K A, Roth
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The Role of the Immune System in Triplet Repeat Expansion Diseases
Mediators of Inflammation, 2015 Trinucleotide repeat expansion disorders (TREDs) are a group of dominantly inherited neurological diseases caused by the expansion of unstable repeats in specific regions of the associated genes.
Marta Olejniczak +2 more
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On the role of RNA binding proteins in polyglutamine diseases: from pathogenesis to therapeutics. [PDF]
Neural Regen Res, 2023 Conceição A, Koppenol R, Nóbrega C.
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Contribution of Glial Cells to Polyglutamine Diseases: Observations from Patients and Mouse Models. [PDF]
Neurotherapeutics, 2023 Cvetanovic M, Gray M.
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A survey of protein interactions and posttranslational modifications that influence the polyglutamine diseases. [PDF]
Front Mol Neurosci, 2022 Johnson SL +4 more
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The emerging roles of long non-coding RNAs in polyglutamine diseases. [PDF]
J Cell Mol Med, 2021 Dong X, Cong S.
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Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation. [PDF]
Int J Mol Sci, 2021 Traa A +5 more
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DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. [PDF]
Neurotherapeutics, 2021 Zhang N +10 more
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Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases. [PDF]
Nucleic Acids Res, 2022 An Y, Chen ZS, Chan HYE, Ngo JCK.
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