Results 21 to 30 of about 635 (158)

Integrated evidence supports a causal association between PHMG-P exposure and pneumonitis [PDF]

Epidemiology and Health
Polyhexamethylene guanidine phosphate (PHMG-P) is a guanidine-based disinfectant previously used in household humidifiers in Korea. This study evaluated whether PHMG-P exposure is causally linked to pneumonitis by integrating epidemiological ...
Yong Joo Park, Hye-Jin Kim, Youngmee Lee, Haewon Kim, Ha Ryong Kim, Jaiyong Kim, Hae-Kwan Cheong, Mina Ha, Kyu Hyuck Chung   +8 more
doaj   +2 more sources

Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis [PDF]

Toxics, 2022
Polyhexamethylene guanidine phosphate (PHMG-p), the main ingredient of humidifier disinfectants, circulates systemically through the lungs; however, its toxicological assessment has been primarily limited to pulmonary disease. Herein, we investigated the
Hwa Jung Sung, Sang Hoon Jeong, Ja Young Kang, Cherry Kim, Yoon Jeong Nam, Jae Young Kim, Jin Young Choi, Hye Jin Lee, Yu Seon Lee, Eun Yeob Kim, Yong Wook Baek, Hong Lee, Ju Han Lee   +12 more
doaj   +2 more sources

Adverse health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate

The Journal of Toxicological Sciences, 2016
Exposure to humidifier disinfectants was identified in 2011 as the potential cause of an outbreak of lung disease in Korea. It is estimated that over 8 million people have been exposed to humidifier disinfectants-chemicals added to the water used in humidifiers to prevent the growth of microorganisms-since their commercial introduction.
Ha-Ryong, Kim, Gi-Wook, Hwang, Akira, Naganuma, Kyu-Hyuck, Chung   +3 more
openaire   +5 more sources

Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver

Ecotoxicology and Environmental Safety, 2022
A public health crisis in the form of a significant incidence of fatal pulmonary disease caused by repeated use of humidifier disinfectants containing polyhexamethylene guanidine phosphate (PHMG) recently arose in Korea.
You-Jin Choi, Hyo-Seon Yang, Yunfan Zhang, Wonseok Lee, Sung Ho Yun, Yoon Ah Nam, Gakyung Lee, Byung Hwa Jung, Tong-Shin Chang, Kyuhong Lee, Byung-Hoon Lee   +10 more
doaj   +3 more sources

Association between humidifier disinfectant use duration and lung cancer development in Korea [PDF]

Epidemiology and Health
OBJECTIVES This study was conducted to assess the association between the duration of humidifier disinfectant use and lung cancer development. METHODS We analyzed data from 3,605 applicants registered for compensation from the Korean government due to ...
Sungchan Kang, Jeong-In Hwang, Su Hwan Kim, Hyungryul Lim, Dong-wook Lee, Woojoo Lee, Jong Hun Kim, Sol Yu, Jungyun Lim, Younghee Kim, Kyoung-Nam Kim   +10 more
doaj   +2 more sources

Concentration-dependent aerosol size alters regional deposition and inhalation dose translation [PDF]

Scientific Reports
Inhalation toxicity assessment relies heavily on quantifying both atmospheric concentration (AC) and region-specific internal dose (ID) within the respiratory tract, especially when comparing in vivo toxicity tests with in vitro respiratory cellular ...
Yurim Choi, Ha Ryong Kim, Jung-Hwan Kwon
doaj   +2 more sources

Assessment of the Diagnostic Value of [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET in a PHMG-p-Induced Pulmonary Fibrosis Murine Model [PDF]

Diagnostics
Background/Objectives: Pulmonary fibrosis is a progressive and fatal lung disease with limited diagnostic and therapeutic options. Fibroblast activation protein (FAP) has emerged as a promising molecular imaging target for the non-invasive assessment of ...
So Young Kim, Jun Young Park, Ye Lim Cho, Won Jun Kang   +3 more
doaj   +2 more sources

Enhancing Lesion Detection in Rat CT Images: A Deep Learning-Based Super-Resolution Study [PDF]

Biomedicines
Background/Objectives: Preclinical chest computed tomography (CT) imaging in small animals is often limited by low resolution due to scan time and dose constraints, which hinders accurate detection of subtle lesions.
Sungwon Ham, Sang Hoon Jeong, Hong Lee, Yoon Jeong Nam, Hyejin Lee, Jin Young Choi, Yu-Seon Lee, Yoon Hee Park, Su A Park, Wooil Kim, Hangseok Choi, Haewon Kim, Ju-Han Lee, Cherry Kim   +13 more
doaj   +2 more sources

Inhalation toxicity of polyhexamethylene guanidine-phosphate in rats: A 4-week inhalation exposure and 24-week recovery period study

Chemosphere, 2023
Humidifier disinfectant (HD) is a causative agent of atypical lung injury reported in 2011 in South Korea, and various diseases caused by HD after exposure cessation have been reported to date. However, there is limited research on most of the reported diseases in terms of their association with HD exposure, and information on the progression of ...
Hyo-Seon Yang, Mijin Yang, Mihyun Kang, Bumseok Kim, Kyuhong Lee   +4 more
openaire   +4 more sources

Toxicological evidence integration to confirm the biological plausibility of the association between humidifier disinfectant exposure and respiratory diseases using the AEP-AOP framework [PDF]

Epidemiology and Health
OBJECTIVES Exposure to humidifier disinfectants has been linked to respiratory diseases, including interstitial lung disease, asthma, and pneumonia. Consequently, numerous toxicological studies have explored respiratory damage as both a necessary and ...
Ha Ryong Kim, Jun Woo Kim, Jong-Hyeon Lee, Younghee Kim, Jungyun Lim, Yong-Wook Baek, Sunkyoung Shin, Mina Ha, Hae-Kwan Cheong, Kyu Hyuck Chung,   +10 more
doaj   +2 more sources