Polyhexamethylene Guanidine Phosphate Induces Apoptosis through Endoplasmic Reticulum Stress in Lung Epithelial Cells [PDF]
Int J Mol Sci, 2021 Airway epithelial cell death contributes to the pathogenesis of lung fibrosis. Polyhexamethylene guanidine phosphate (PHMG-p), commonly used as a disinfectant, has been shown to be strongly associated with lung fibrosis in epidemiological and ...
M. Jeong +3 more
semanticscholar +3 more sources
A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate [PDF]
Biomol Ther (Seoul), 2021 Liver fibrosis is part of the wound healing process to help the liver recover from the injuries caused by various liver-damaging insults. However, liver fibrosis often progresses to life-threatening cirrhosis and hepatocellular carcinoma. To overcome the
Minjeong Kim +7 more
semanticscholar +4 more sources
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells [PDF]
BMC Pharmacology and Toxicology, 2022 Background Lung injury elicited by respiratory exposure to humidifier disinfectants (HDs) is known as HD-associated lung injury (HDLI). Current elucidation of the molecular mechanisms related to HDLI is mostly restricted to fibrotic and inflammatory lung
Hong Lee +11 more
doaj +3 more sources
Evaluation of the long-term effect of polyhexamethylene guanidine phosphate in a rat lung model using conventional chest computed tomography with histopathologic analysis. [PDF]
PLoS ONE, 2021 There have been no studies on the effects of polyhexamethylene guanidine phosphate (PHMG) after a long period of exposure in the rodent model. We aimed to evaluate long-term lung damage after PHMG exposure using conventional chest computed tomography (CT)
Cherry Kim +10 more
doaj +3 more sources
Polyhexamethylene guanidine phosphate exposure induces abnormal behaviors by disrupting synaptic formation and activity in the cerebral cortex [PDF]
Journal of NeuroinflammationBackground Polyhexamethylene guanidine phosphate (PHMG-p), a commonly utilized ingredient in humidifier disinfectants, has emerged as a primary factor contributing to pulmonary damage, asthmatic conditions, and prenatal complications in South Korea ...
Moon Yi Ko +11 more
doaj +3 more sources
Ecotoxicology and Environmental Safety, 2023 Polyhexamethylene guanidine phosphate (PHMG-p), used as a humidifier disinfectant, causes interstitial lung disease, obliterative bronchiolitis, and lung fibrosis; however, little is known about its effect on intercellular interactions.
Hyung Sik Kim +2 more
exaly +4 more sources
Ecotoxicology and Environmental Safety, 2022 Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to cause lung toxicity, including inflammation and pulmonary fibrosis.
Seri Choi +9 more
doaj +3 more sources
Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium [PDF]
Environmental Health and Toxicology, 2019 Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an ...
Juyoung Park, Handule Lee, Kwangsik Park
doaj +3 more sources
Ecotoxicology and Environmental SafetyInhalation exposure to polyhexamethylene guanidine phosphate (PHMG-p), a primary component of humidifier disinfectants, has been linked to interstitial lung disease and potential carcinogenic effects.
Gi Ho Lee +5 more
doaj +3 more sources
Ecotoxicology and Environmental Safety, 2022 A public health crisis in the form of a significant incidence of fatal pulmonary disease caused by repeated use of humidifier disinfectants containing polyhexamethylene guanidine phosphate (PHMG) recently arose in Korea.
You-Jin Choi +10 more
doaj +2 more sources