Results 21 to 30 of about 2,197 (135)
Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium [PDF]
Environmental Health and Toxicology, 2019 Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an ...
Juyoung Park, Handule Lee, Kwangsik Park
doaj +3 more sources
Ecotoxicology and Environmental SafetyInhalation exposure to polyhexamethylene guanidine phosphate (PHMG-p), a primary component of humidifier disinfectants, has been linked to interstitial lung disease and potential carcinogenic effects.
Gi Ho Lee +5 more
doaj +3 more sources
Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis [PDF]
Toxics, 2022 Polyhexamethylene guanidine phosphate (PHMG-p), the main ingredient of humidifier disinfectants, circulates systemically through the lungs; however, its toxicological assessment has been primarily limited to pulmonary disease. Herein, we investigated the
Hwa Jung Sung +12 more
doaj +3 more sources
Ecotoxicology and Environmental SafetyIn this study, we investigated the potential mechanisms by which polyhexamethylene guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer development.
Yong Joo Park +7 more
doaj +4 more sources
Food and Chemical ToxicologyThis study investigated the median lethal dose and target organs of polyhexamethylene guanidine phosphate (PHMG-P)-an antimicrobial disinfectant-administered via single-dose intravenous injection (IV; 3.13, 6.25, or 12.5 mg/kg) and intratracheal ...
In-Sik Shin +2 more
exaly +4 more sources
Toxicological evidence integration to confirm the biological plausibility of the association between humidifier disinfectant exposure and respiratory diseases using the AEP-AOP framework [PDF]
Epidemiology and HealthOBJECTIVES Exposure to humidifier disinfectants has been linked to respiratory diseases, including interstitial lung disease, asthma, and pneumonia. Consequently, numerous toxicological studies have explored respiratory damage as both a necessary and ...
Ha Ryong Kim +10 more
doaj +3 more sources
Journal of Toxicological Sciences, 2019 Polyhexamethylene guanidine phosphate (PHMG-p) is an active ingredient of humidifier disinfectants and causes severe lung injury resulting in pulmonary fibrosis.
Yong Joo Park +2 more
exaly +5 more sources
Ecotoxicology and Environmental Safety, 2022 A public health crisis in the form of a significant incidence of fatal pulmonary disease caused by repeated use of humidifier disinfectants containing polyhexamethylene guanidine phosphate (PHMG) recently arose in Korea.
You-Jin Choi +10 more
doaj +2 more sources
A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals [PDF]
Environmental Health and Toxicology, 2018 Several studies showed that the inflammatory and fibrotic responses induced by polyhexamethylene guanidine phosphate (PHMG-p) were similar to those observed for idiopathic pulmonary fibrosis in South Korea in 2011.
Ha Ryong Kim +2 more
doaj +2 more sources
Flexible-Imaging-Fiber-Guided Intratracheal Intubation in Rodents
Applied Sciences, 2023 Although experiments on intratracheal intubation for animals are essential for research, it remains challenging. This study aimed to validate an animal model using a flexible imaging guide system that can be conveniently and safely used as a new method ...
Sang Hoon Jeong +8 more
doaj +2 more sources