Ecotoxicology and Environmental SafetyIn this study, we investigated the potential mechanisms by which polyhexamethylene guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer development.
Yong Joo Park +7 more
doaj +2 more sources
Integrated evidence supports a causal association between PHMG-P exposure and pneumonitis [PDF]
Epidemiology and HealthPolyhexamethylene guanidine phosphate (PHMG-P) is a guanidine-based disinfectant previously used in household humidifiers in Korea. This study evaluated whether PHMG-P exposure is causally linked to pneumonitis by integrating epidemiological ...
Yong Joo Park +8 more
doaj +2 more sources
Acta Odontologica Scandinavica, 2019 Objective: To evaluate the efficacy of adjunctive polyhexamethylene guanidine (PHMG) phosphate irrigation in periodontal treatment. Materials and Methods: The subjects comprised 59 patients with severe chronic periodontitis.
A. Vitt +5 more
semanticscholar +2 more sources
Journal of Toxicological Sciences, 2019 Polyhexamethylene guanidine phosphate (PHMG-p) is an active ingredient of humidifier disinfectants and causes severe lung injury resulting in pulmonary fibrosis.
Yong Joo Park +2 more
exaly +2 more sources
Association between humidifier disinfectant use duration and lung cancer development in Korea [PDF]
Epidemiology and HealthOBJECTIVES This study was conducted to assess the association between the duration of humidifier disinfectant use and lung cancer development. METHODS We analyzed data from 3,605 applicants registered for compensation from the Korean government due to ...
Sungchan Kang +10 more
doaj +2 more sources
Concentration-dependent aerosol size alters regional deposition and inhalation dose translation [PDF]
Scientific ReportsInhalation toxicity assessment relies heavily on quantifying both atmospheric concentration (AC) and region-specific internal dose (ID) within the respiratory tract, especially when comparing in vivo toxicity tests with in vitro respiratory cellular ...
Yurim Choi, Ha Ryong Kim, Jung-Hwan Kwon
doaj +2 more sources
Assessment of the Diagnostic Value of [68Ga]Ga-FAPI-04 and [18F]FDG PET in a PHMG-p-Induced Pulmonary Fibrosis Murine Model [PDF]
DiagnosticsBackground/Objectives: Pulmonary fibrosis is a progressive and fatal lung disease with limited diagnostic and therapeutic options. Fibroblast activation protein (FAP) has emerged as a promising molecular imaging target for the non-invasive assessment of ...
So Young Kim +3 more
doaj +2 more sources
Toxicological evidence integration to confirm the biological plausibility of the association between humidifier disinfectant exposure and respiratory diseases using the AEP-AOP framework [PDF]
Epidemiology and HealthOBJECTIVES Exposure to humidifier disinfectants has been linked to respiratory diseases, including interstitial lung disease, asthma, and pneumonia. Consequently, numerous toxicological studies have explored respiratory damage as both a necessary and ...
Ha Ryong Kim +10 more
doaj +2 more sources
Enhancing Lesion Detection in Rat CT Images: A Deep Learning-Based Super-Resolution Study [PDF]
BiomedicinesBackground/Objectives: Preclinical chest computed tomography (CT) imaging in small animals is often limited by low resolution due to scan time and dose constraints, which hinders accurate detection of subtle lesions.
Sungwon Ham +13 more
doaj +2 more sources
Antimicrobial activity of polyhexamethylene guanidine phosphate in comparison to chlorhexidine using the quantitative suspension method. [PDF]
Ann Clin Microbiol Antimicrob, 2015 Background: Polyhexamethylene guanidine phosphate (PHMG-P) belongs to the polymeric guanidine family of biocides and contains a phosphate group, which may confer better solubility, a detoxifying effect and may change the kinetics and dynamics of PHMG-P ...
Vitt A +8 more
europepmc +2 more sources