Results 31 to 40 of about 2,197 (135)

Deciphering the toxicity of polyhexamethylene guanidine phosphate in lung carcinogenesis: Mutational profiles and molecular mechanisms.

Chemosphere
Polyhexamethylene guanidine (PHMG) is widely utilized in personal hygiene products due to its bactericidal, non-volatile, and hydrophilic properties. However, the long-term toxic effects and underlying mechanisms associated with respiratory exposure to ...
Hong Lee, Sang-Hoon Jeong, Yong-Wook Baek, Hyejin Lee, Jason K. Sa, Ji Yoon Lee, Yu-Seon Lee, Y. Nam, Jaeyoung Kim, Jonghoon Kim, J. Choi, Su A. Park, Je Hyeong Kim, Yoon Hee Park, Jungyun Lim, Young-Hee Kim, Eun-Kee Park, Cherry Kim, Ju-Han Lee   +18 more
semanticscholar   +3 more sources

Safety study, anti-inflammatory and antioxidant action of drug caramel with polyhexamethylene guanidine phosphate

International Journal of Basic and Clinical Pharmacology, 2016
Background: Among the new antiseptic medicines, most meeting modern requirements in terms of treatment of microbial invasion are one of the leading positions occupied by the polymeric guanidine compound. Polyhexamethylene guanidine phosphate (PHMGP) has a wide spectrum of antimicrobial activity and practical absence of toxicity.
Anton Kurinnyi, Igor Belenichev, Vitalii Hladyshev   +2 more
openaire   +3 more sources

Integrated evidence supports a causal association between PHMG-P exposure and pneumonitis [PDF]

Epidemiology and Health
Polyhexamethylene guanidine phosphate (PHMG-P) is a guanidine-based disinfectant previously used in household humidifiers in Korea. This study evaluated whether PHMG-P exposure is causally linked to pneumonitis by integrating epidemiological ...
Yong Joo Park, Hye-Jin Kim, Youngmee Lee, Haewon Kim, Ha Ryong Kim, Jaiyong Kim, Hae-Kwan Cheong, Mina Ha, Kyu Hyuck Chung   +8 more
doaj   +2 more sources

Adverse health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate

Journal of Toxicological Sciences, 2016
Exposure to humidifier disinfectants was identified in 2011 as the potential cause of an outbreak of lung disease in Korea. It is estimated that over 8 million people have been exposed to humidifier disinfectants-chemicals added to the water used in humidifiers to prevent the growth of microorganisms-since their commercial introduction.
Kyu-Hyuck Chung
exaly   +4 more sources

Corrigendum to “Comprehensive analysis of adverse outcome pathway, potency, human exposure supports carcinogenicity of polyhexamethylene guanidine phosphate in lung cancer” [Ecotoxicol. Environ. Saf. 287 (2024) 117222]

Ecotoxicology and Environmental Safety
Yong Joo Park, Ha Ryong Kim, Jun Woo Kim, Jong-Hyun Lee, Younghee Kim, Jungyun Lim, Yong-Wook Baek, Kyu Hyuck Chung   +7 more
doaj   +3 more sources

Inhalation toxicity of polyhexamethylene guanidine-phosphate in rats: A 4-week inhalation exposure and 24-week recovery period study1.

Chemosphere, 2022
Humidifier disinfectant (HD) is a causative agent of atypical lung injury reported in 2011 in South Korea, and various diseases caused by HD after exposure cessation have been reported to date.
Hyo-Seon Yang, M. Yang, Mihyun Kang, Bumseok Kim, Kyuhong Lee   +4 more
semanticscholar   +3 more sources

Humidifier disinfectant lung injury, how do we approach the issues? [PDF]

Environmental Health and Toxicology, 2016
A large portion of the Korean population has been exposed to toxic humidifier disinfectants (HDs), and considering that the majority of the victims are infants, the magnitude of the damage is expected to be considerably larger than what has currently ...
Jihyun Emma Choi, Sang-Bum Hong, Kyung-Hyun Do, Hwa Jung Kim, Seockhoon Chung, Eun Lee, Jihyun Choi, Soo-Jong Hong   +7 more
doaj   +2 more sources

Organic Polyurethane Surface Structures to Manufacture Noneluting Antimicrobial Polyurethanes: A Systematic Review of Literature. [PDF]

Biomed Res Int
The dramatic increase in hospital‐acquired infections and healthcare costs associated with infection treatment and antimicrobial resistance in implant infections necessitates further research and development of antimicrobial implant material properties. Polyurethanes are key biomaterials used in medical implants and devices.
Hurck BJ, Vargas Guerrero MG, de Boer C, Dias AA, Arts JJC.   +4 more
europepmc   +2 more sources

Kathon Induces Fibrotic Inflammation in Lungs: The First Animal Study Revealing a Causal Relationship between Humidifier Disinfectant Exposure and Eosinophil and Th2-Mediated Fibrosis Induction

Molecules, 2020
Currently available toxicity data on humidifier disinfectants are primarily limited to polyhexamethylene guanidine phosphate-induced lung fibrosis.
Mi-Kyung Song, Dong Im Kim, Kyuhong Lee
doaj   +2 more sources

Association between humidifier disinfectant use duration and lung cancer development in Korea [PDF]

Epidemiology and Health
OBJECTIVES This study was conducted to assess the association between the duration of humidifier disinfectant use and lung cancer development. METHODS We analyzed data from 3,605 applicants registered for compensation from the Korean government due to ...
Sungchan Kang, Jeong-In Hwang, Su Hwan Kim, Hyungryul Lim, Dong-wook Lee, Woojoo Lee, Jong Hun Kim, Sol Yu, Jungyun Lim, Younghee Kim, Kyoung-Nam Kim   +10 more
doaj   +2 more sources