Results 31 to 40 of about 635 (158)

Time-course transcriptomic alterations reflect the pathophysiology of polyhexamethylene guanidine phosphate-induced lung injury in rats

open access: yesInhalation Toxicology, 2019
Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial agent, is a major component ...
Mi-Kyung, Song   +2 more
openaire   +4 more sources

Comprehensive analysis of adverse outcome pathway, potency, human exposure supports carcinogenicity of polyhexamethylene guanidine phosphate in lung cancer

open access: yesEcotoxicology and Environmental Safety
In this study, we investigated the potential mechanisms by which polyhexamethylene guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer development.
Yong Joo Park   +7 more
doaj   +3 more sources

Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells

open access: yesThe Journal of Toxicological Sciences, 2019
Polyhexamethylene guanidine phosphate (PHMG-p) is an active ingredient of humidifier disinfectants and causes severe lung injury resulting in pulmonary fibrosis. Current evidence indicates that pulmonary fibrosis is initiated as a result of epithelial damage, which can lead to an inflammatory response and fibrotic cell infiltration; however, the toxic ...
Ji Soo, Park   +3 more
openaire   +5 more sources

Микрофлюидный метод как перспективная технология для синтеза антимикробных соединений [PDF]

open access: yes, 2022
Objectives. The study aimed to analyze the current antiseptics and disinfectants, explore the possibility of synthesizing various antiseptics including oligohexamethylene guanidine hydrochloride (OHMG-HC) using microfluidic technology, and investigate ...
A. С. Ha, А. К. Ха
core   +2 more sources

Flexible-Imaging-Fiber-Guided Intratracheal Intubation in Rodents

open access: yesApplied Sciences, 2023
Although experiments on intratracheal intubation for animals are essential for research, it remains challenging. This study aimed to validate an animal model using a flexible imaging guide system that can be conveniently and safely used as a new method ...
Sang Hoon Jeong   +8 more
doaj   +1 more source

Bio‐inspired synthesis of bio‐hydroxyapatite/synthetic hydroxyapatite hybrid nanosystems

open access: yesMedComm – Biomaterials and Applications, Volume 2, Issue 4, December 2023., 2023
Novel hydroxyapatite hybrid nanosystems (HAp‐HNS) combining biogenic and synthetic HAp are important for their versatile applications and tailored properties, which optimize them for specific applications. They are biocompatible for bone regeneration due to substitutional ions.
Luis F. Zubieta‐Otero   +3 more
wiley   +1 more source

Occupational interstitial lung diseases

open access: yesJournal of Internal Medicine, Volume 294, Issue 6, Page 798-815, December 2023., 2023
Abstract Millions of workers are exposed to substances known to cause occupational interstitial lung diseases (ILDs), particularly in developing countries. However, the burden of the disease is likely to be underestimated due to under‐recognition, under‐reporting or both.
Paolo Spagnolo   +11 more
wiley   +1 more source

Oleanolic acid regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the TGF‐β1/SMAD signaling pathway

open access: yesJournal of Cosmetic Dermatology, Volume 22, Issue 7, Page 2083-2089, July 2023., 2023
Abstract Background Keloid (KD) is a unique pathological fibroproliferative disease that seriously affects the appearance of patients. This study investigated the effect of oleanolic acid (OA) on the proliferation of keloid fibroblasts (KFs) and the expression of extracellular matrix (ECM)‐related proteins.
Yinli Luo   +4 more
wiley   +1 more source

Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment

open access: yesAdvanced Science, Volume 9, Issue 29, October 14, 2022., 2022
This review first describes the formation of biofilms in various clinical scenarios and their clinical management. Then, the established biofilms models used in research and the potential targets for biofilms are discussed. Finally, this review highlights the emerging novel technologies for the prevention and treatment of biofilms.
Yajuan Su   +6 more
wiley   +1 more source

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