Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells [PDF]
BMC Pharmacology and Toxicology, 2022 Background Lung injury elicited by respiratory exposure to humidifier disinfectants (HDs) is known as HD-associated lung injury (HDLI). Current elucidation of the molecular mechanisms related to HDLI is mostly restricted to fibrotic and inflammatory lung
Hong Lee +11 more
doaj +4 more sources
Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis [PDF]
Toxics, 2022 Polyhexamethylene guanidine phosphate (PHMG-p), the main ingredient of humidifier disinfectants, circulates systemically through the lungs; however, its toxicological assessment has been primarily limited to pulmonary disease. Herein, we investigated the
Hwa Jung Sung +12 more
doaj +2 more sources
Integrated evidence supports a causal association between PHMG-P exposure and pneumonitis [PDF]
Epidemiology and HealthPolyhexamethylene guanidine phosphate (PHMG-P) is a guanidine-based disinfectant previously used in household humidifiers in Korea. This study evaluated whether PHMG-P exposure is causally linked to pneumonitis by integrating epidemiological ...
Yong Joo Park +8 more
doaj +2 more sources
Polyhexamethylene Guanidine Phosphate Induces Restrictive Ventilation Defect and Alters Lung Resistance and Compliance in Mice [PDF]
ToxicsPolyhexamethylene guanidine phosphate (PHMG-p), a major ingredient of humidifier disinfectants, is known to induce inflammation, interstitial pneumonitis, and fibrosis in the lungs.
Yoon Hee Park +16 more
doaj +2 more sources
Polyhexamethylene Guanidine Phosphate Enhanced Procoagulant Activity through Oxidative-Stress-Mediated Phosphatidylserine Exposure in Platelets [PDF]
ToxicsPolyhexamethylene guanidine phosphate (PHMG-p) is a common biocidal disinfectant that is widely used in industry and household products. However, PHMG-p was misused as a humidifier disinfectant (HD) in South Korea, which had fatal health effects. Various
Ju Hee Choi, Keunyoung Kim
doaj +2 more sources
Assessment of the Diagnostic Value of [68Ga]Ga-FAPI-04 and [18F]FDG PET in a PHMG-p-Induced Pulmonary Fibrosis Murine Model [PDF]
DiagnosticsBackground/Objectives: Pulmonary fibrosis is a progressive and fatal lung disease with limited diagnostic and therapeutic options. Fibroblast activation protein (FAP) has emerged as a promising molecular imaging target for the non-invasive assessment of ...
So Young Kim +3 more
doaj +2 more sources
Evaluation of the long-term effect of polyhexamethylene guanidine phosphate in a rat lung model using conventional chest computed tomography with histopathologic analysis. [PDF]
PLoS ONE, 2021 There have been no studies on the effects of polyhexamethylene guanidine phosphate (PHMG) after a long period of exposure in the rodent model. We aimed to evaluate long-term lung damage after PHMG exposure using conventional chest computed tomography (CT)
Cherry Kim +10 more
doaj +2 more sources
Non-Destructive Monitoring via Electrochemical NADH Detection in Murine Cells [PDF]
Biosensors, 2022 Nicotinamide adenine dinucleotide (NADH) is an important cofactor involved in metabolic redox reactions in living cells. The detection of NADH in living animal cells is a challenge.
Ju Kyung Lee +6 more
doaj +2 more sources
Subchronic particulate matter exposure underlying polyhexamethylene guanidine phosphate–induced lung injury: Quantitative and qualitative evaluation with chest computed tomography [PDF]
HeliyonOur study was to explore the effects of subchronic particulate matter (PM) exposure on lung injury induced by polyhexamethylene guanidine phosphate (PHMG-p) in a rat model.
Cherry Kim +9 more
doaj +2 more sources
Enhancing Lesion Detection in Rat CT Images: A Deep Learning-Based Super-Resolution Study [PDF]
BiomedicinesBackground/Objectives: Preclinical chest computed tomography (CT) imaging in small animals is often limited by low resolution due to scan time and dose constraints, which hinders accurate detection of subtle lesions.
Sungwon Ham +13 more
doaj +2 more sources