Results 141 to 150 of about 31,758 (236)

Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2–dependent statine pathway

Nature Communications
Pepstatins are potent inhibitors of aspartic proteases, featuring two statine residues crucial for target binding. However, the biosynthesis of pepstatins, especially their statine substructure, remains elusive.
Jingjun Mo, Asfandyar Sikandar, Haowen Zhao, Ghader Bashiri, Liujie Huo, Martin Empting, Rolf Müller, Chengzhang Fu   +7 more
doaj   +1 more source

Evolutionary Reprogramming of Acyltransferase Domains in Polyene Macrolide Pathways

Microorganisms
The evolution of type I polyketide synthase (T1PKS) assembly lines remains poorly understood. Through systematic mining of polyene biosynthetic gene clusters, we identified a novel eurocidin biosynthetic pathway capable of producing identical compounds ...
Liran Zhang, Jinwei Ren, Chengyu Zhang, Lixin Zhang, Bin Wang, Jingyu Zhang   +5 more
doaj   +1 more source

Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase [PDF]

RSC Chem Biol
Foran ME, Ho YTC, Lewandowski JR, Jenner M.   +3 more
europepmc   +2 more sources

Polyketide Synthases

Acta Scientific Microbiology, 2019
openaire   +1 more source

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium. [PDF]

FEBS Open Bio
Yamashita TR, Usuki T, Kay RR, Saito T.
europepmc   +1 more source

A hybrid assembly mechanism employs nonreducing polyketide synthase-like logic for partially reduced polyketide formation. [PDF]

Mar Life Sci Technol
Zhang X, Ma C, Deng Z, Ren X, Zhang K, Wang W, Zhou L, Zhu Y, Zhang G, Che Q, Zhu T, Long H, Dong B, Li D.   +13 more
europepmc   +1 more source

Structure and Function of the α-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase. [PDF]

Angew Chem Int Ed Engl, 2023
Winter AJ, Khanizeman RN, Barker-Mountford AMC, Devine AJ, Wang L, Song Z, Davies JA, Race PR, Williams C, Simpson TJ, Willis CL, Crump MP.   +11 more
europepmc   +2 more sources

Engineering of FK520 polyketide synthase for rapid access to quality control reference standards. [PDF]

Microb Cell Fact
Žigart N, Pivk Lukančič P, Drčar T, Peterka J, Harej Perko M, Mrak P.   +5 more
europepmc   +1 more source

Functional Characterization of Polyketide Synthase Clusters in Streptomyces anandii J6. [PDF]

Plant Pathol J
Kim DR, Kwak YS.
europepmc   +1 more source

High polyketide synthase gene expression boosts pathogenicity of Klebsiella pneumoniae in the digestive infection. [PDF]

Sci Rep
Luo C, Huang W, Shi Y, Chen S, Lin Y, Yang B.   +5 more
europepmc   +1 more source