Results 1 to 10 of about 30,531 (224)
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]
Angewandte Chemie - International Edition, 2018 AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Eric Jan Nikolaus Helfrich +2 more
exaly +6 more sources
Structural control of polyketide formation in plant-specific polyketide synthases [PDF]
Chemistry and Biology, 2000 Polyketide synthases (PKSs) generate molecular diversity by utilizing different starter molecules and by controlling the final length of the polyketide. Although exploitation of this mechanistic variability has produced novel polyketides, the structural foundation of this versatility is unclear. Plant-specific PKSs are essential for the biosynthesis of
Juan Ferrer, Joseph Jez, Joseph Noel
exaly +3 more sources
The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases
Molecules, 2011 Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis. In modular PKSs, the polyketide chain is assembled by the successive condensation of activated carboxylic acid-derived units, where chain extension occurs with ...
David Kwan, Frank Schulz
exaly +5 more sources
New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
Antibiotics, 2022 New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7), were isolated ...
Fuhang Song +5 more
doaj +1 more source
Hydrobiology, 2023 Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin and cyclo(Phe-Leu).
Hisayuki Komaki +2 more
doaj +1 more source
First Identification of Amphidinols from Mexican Strains and New Analogs
Toxins, 2023 The genus Amphidinium has been the subject of recent attention due to the production of polyketide metabolites. Some of these compounds have shown significant bioactivities and could be related to species interactions in the natural benthic ...
Lorena M. Durán-Riveroll +2 more
doaj +1 more source
Marine Drugs, 2023 Chemical epigenetic cultivation of the sponge-derived fungus Pestalotiopsis sp. SWMU-WZ04-1 contributed to the identification of twelve polyketide derivatives, including six new pestalotiopols E–J (1–6) and six known analogues (7–12).
Liyuan Jiang +7 more
doaj +1 more source
Frontiers in Plant Science, 2020 Extracellular vesicles (EVs) represent a system for the coordinated secretion of a variety of molecular cargo including proteins, lipids, nucleic acids, and metabolites.
Mark R. Bleackley +9 more
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Biosynthesis of Fungal Natural Products Involving Two Separate Pathway Crosstalk
Journal of Fungi, 2022 Fungal natural products (NPs) usually possess complicated structures, exhibit satisfactory bioactivities, and are an outstanding source of drug leads, such as the cholesterol-lowering drug lovastatin and the immunosuppressive drug mycophenolic acid.
Guangzhi Dai +3 more
doaj +1 more source
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in
mSphere, 2020 Colibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle progression in eukaryotes.
Alexander Wallenstein +16 more
doaj +1 more source