Results 31 to 40 of about 42,850 (196)
Marine Drugs, 2020 A new pentaketide derivative, penilactonol A (1), and two new hydroxyphenylacetic acid derivatives, (2’R)-stachyline B (2) and (2’R)-westerdijkin A (3), together with five known metabolites, bisabolane-type sesquiterpenoids 4–6 and meroterpenoids 7 and 8,
Lin-Lin Jiang +9 more
doaj +1 more source
Cellular compartmentalization of secondary metabolism
Frontiers in Microbiology, 2015 Fungal secondary metabolism is often considered apart from the essential housekeeping functions of the cell. However, there are clear links between fundamental cellular metabolism and the biochemical pathways leading to secondary metabolite synthesis ...
H. Corby eKistler, Karen eBroz
doaj +1 more source
Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis
mBio, 2020 Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ)
Kangmin Hua +7 more
doaj +1 more source
Manipulating polyketide stereochemistry by exchange of polyketide synthase modules
Chemical Communications, 2020 Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo +3 more
openaire +4 more sources
Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity [PDF]
, 2013 Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3).
Calcinai, Barbara +24 more
core +1 more source
The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]
, 2014 Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Gerc, Amy J. +2 more
core +1 more source
Antibacterial and Antifungal Compounds from Marine Fungi
Marine Drugs, 2015 This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.
Lijian Xu +5 more
doaj +1 more source
Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans [PDF]
, 2013 BACKGROUND: Mycolactones are a family of polyketide-derived macrolide exotoxins produced by Mycobacterium ulcerans, the causative agent of the chronic necrotizing skin disease Buruli ulcer.
Gerd Pluschke +27 more
core +2 more sources
Life, 2020 (1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites.
Hisayuki Komaki, Tomohiko Tamura
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Effect of the Marine Polyketide Plocabulin on Tumor Progression
Marine Drugs, 2022 Marine sponges represent one of the richest sources of natural marine compounds with anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the sponge Lithoplocamia lithistoides, elicits its main anticancer properties binding ...
Eleonora Turrini +2 more
doaj +1 more source