Results 21 to 30 of about 42,850 (196)

A New Polyketide from the Endophytic Fungus Penicillium chermesinum

Indonesian Journal of Chemistry, 2017
A new polyketide derivative, 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one (1), was isolated from the endophytic fungus Penicillium chermesinum.
Cici Darsih, Vilailak Prachyawarakorn, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop   +4 more
doaj   +1 more source

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
core   +2 more sources

Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf

Marine Drugs, 2023
To discover bioactive natural products from mangrove sediment-derived microbes, a chemical investigation of the two Beibu Gulf-derived fungi strains, Talaromyces sp. SCSIO 41050 and Penicillium sp. SCSIO 41411, led to the isolation of 23 natural products.
Bo Peng, Jian Cai, Zimin Xiao, Manli Liu, Xinlong Li, Bin Yang, Wei Fang, Yi-You Huang, Chunmei Chen, Xuefeng Zhou, Huaming Tao   +10 more
doaj   +1 more source

Synthetic biology of fungal natural products [PDF]

, 2015
This work was supported by the DFG-funded excellence graduate school Jena School for Microbial Communication (JSMC; DJM, AAB), the collaborative research center (SFB) 1127 Chemical Mediators in Complex Biosystems (ChemBioSys—AAB, project B02) and the ...
Vito Valiante, Unkles, S.E., Mattern, D.J., Valiante, V., Brakhage, A.A., Derek J. Mattern, Axel A. Brakhage, Shiela E. Unkles   +7 more
core   +1 more source

Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis XWS03F09

Molecules, 2019
Four new compounds, including two new polyketides, heterocornols M and N (1, 2), and a pair of epimers, heterocornols O and P (3, 4), were isolated from the fermentation broth of the marine sponge-derived fungus Pestalotiopsis heterocornis XWS03F09 ...
Hui Lei, Jing Lei, Xuefeng Zhou, Mei Hu, Hong Niu, Can Song, Siwei Chen, Yonghong Liu, Dan Zhang   +8 more
doaj   +1 more source

Iterative polyketide biosynthesis by modular polyketide synthases in bacteria [PDF]

Applied Microbiology and Biotechnology, 2015
Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is non-iterative in function.
Haotong, Chen, Liangcheng, Du
openaire   +2 more sources

Module-Based Polyketide Synthase Engineering for de Novo Polyketide Biosynthesis [PDF]

, 2023
Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and function, has the potential to produce millions of organic molecules ...
Haushalter, Robert W, Nava, Alberto A, Keasling, Jay D, Wang, Zilong, Keasling, Jay D., Haushalter, Robert W., Roberts, Jacob, Nava, Alberto A.   +7 more
core   +1 more source

A Structural Analysis of the Angucycline-Like Antibiotic Auricin from Streptomyces lavendulae Subsp. Lavendulae CCM 3239 Revealed Its High Similarity to Griseusins

Antibiotics, 2019
We previously identified the aur1 gene cluster in Streptomyces lavendulae subsp. lavendulae CCM 3239 (formerly Streptomyces aureofaciens CCM 3239), which is responsible for the production of the angucycline-like antibiotic auricin (1).
Maria Matulova, Lubomira Feckova, Renata Novakova, Erik Mingyar, Dominika Csolleiova, Martina Zduriencikova, Jan Sedlak, Vladimir Patoprsty, Vlasta Sasinkova, Iveta Uhliarikova, Beatrica Sevcikova, Bronislava Rezuchova, Dagmar Homerova, Jan Kormanec   +13 more
doaj   +1 more source

Polyketides from a Marine-Derived Fungus Xylariaceae sp.

Marine Drugs, 2013
Eighteen polyketides (1–18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp ...
Shu-Hua Qi, Xiao-Yong Zhang, Xu-Hua Nong, Zhi-Hui Zheng, Xin-Hua Lu   +4 more
doaj   +1 more source

New Insights on Biological Activities, Chemical Compositions, and Classifications of Marine Actinomycetes Antifouling Agents

Microorganisms, 2023
Biofouling is the assemblage of undesirable biological materials and macro-organisms (barnacles, mussels, etc.) on submerged surfaces, which has unfavorable impacts on the economy and maritime environments.
Radwa N. Morgan, Amer Al Ali, Mohammad Y. Alshahrani, Khaled M. Aboshanab   +3 more
doaj   +1 more source