Results 21 to 30 of about 39,295 (245)
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in
mSphere, 2020 Colibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle progression in eukaryotes.
Alexander Wallenstein +16 more
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eLife, 2020 Microorganisms produce numerous secondary metabolites (SMs) with various biological activities. Many of their encoding gene clusters are silent under standard laboratory conditions because for their activation they need the ecological context, such as ...
Maria Cristina Stroe +6 more
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The Toughest Material in the Plant Kingdom: An Update on Sporopollenin
Frontiers in Plant Science, 2021 The extreme chemical and physical recalcitrance of sporopollenin deems this biopolymer among the most resilient organic materials on Earth. As the primary material fortifying spore and pollen cell walls, sporopollenin is touted as a critical innovation ...
Etienne Grienenberger +1 more
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mSystems, 2023 Actinomycetes are prolific producers of industrially valuable and medically important compounds. Historically, the most efficient method of obtaining compounds has been bioactivity-guided isolation and characterization of drug-like molecules from ...
Peng Hou +5 more
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Marine Drugs, 2021 Two new polyketide natural products, globosuxanthone F (1), and 2′-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3 ...
Jing Zhou +10 more
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Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery
Cells, 2018 The cellular slime mold Dictyostelium discoideum is an excellent model organism for the study of cell and developmental biology because of its simple life cycle and ease of use.
Yuzuru Kubohara, Haruhisa Kikuchi
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Beilstein Journal of Organic Chemistry, 2021 Three new tetronate-class polyketides, nomimicins B, C, and D, along with nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp.
Zhiwei Zhang +9 more
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Marine Drugs, 2022 Marine fungi-derived secondary metabolites are still an important source for the discovery of potential antimicrobial agents. Here, five new polyketides (1, 2, and 6–8) and seven known compounds (3–5 and 9–12) were obtained from the culture of the marine-
Changrong Lai +8 more
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Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]
, 2009 OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali +4 more
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Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388
Journal of Fungi, 2023 Seven new polyketides named fusarisolins F-K (1–6) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10).
Cankai Lin +9 more
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