Results 11 to 20 of about 42,850 (196)
Polyketide synthesis in vitro on a modular polyketide synthase [PDF]
Chemistry & Biology, 1995 The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated DEBS1-3). This complexity has hitherto frustrated mechanistic analysis of such enzymes.
Wiesmann, Kirsten E.H. +5 more
openaire +3 more sources
Structure determination of a 4-pyrone from the liverwort Plagiochila bifaria (Sw.) Lindenb. (Plagiochilaceae) [PDF]
, 2008 The centenary of the presentation in 1907 of the "polyketide" hypothesis by Collie, along with his use of a 4-pyrone as an example, is marked by reporting the discovery and isolation of 2-(3,4-dimethoxyphenethyl)-6-methyl-4-pyrone from <i> ...
Rycroft, D.S.
core +8 more sources
Heterocycles, 2007 I. Introduction 1. A Plethora of Polyketides: Structures, Biological Activities, and Enzymes - Scott R. Baerson and Agnes M. Rimando II. Polyketide Biosynthesis in Plants and Microorganisms 2. Hygromycin A Biosynthesis - Nadaraj Palaniappan and Kevin Reynolds 3. The Biosynthesis of Polyketides, Tetramic Acids and Pyridones in Fungi - Russell J.
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Marine Drugs, 2021 Two new polyketide natural products, globosuxanthone F (1), and 2′-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3 ...
Jing Zhou +10 more
doaj +1 more source
Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery
Cells, 2018 The cellular slime mold Dictyostelium discoideum is an excellent model organism for the study of cell and developmental biology because of its simple life cycle and ease of use.
Yuzuru Kubohara, Haruhisa Kikuchi
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2021 Three new tetronate-class polyketides, nomimicins B, C, and D, along with nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp.
Zhiwei Zhang +9 more
doaj +1 more source
Marine Drugs, 2022 Marine fungi-derived secondary metabolites are still an important source for the discovery of potential antimicrobial agents. Here, five new polyketides (1, 2, and 6–8) and seven known compounds (3–5 and 9–12) were obtained from the culture of the marine-
Changrong Lai +8 more
doaj +1 more source
Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]
, 2009 OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali +4 more
core +1 more source
Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388
Journal of Fungi, 2023 Seven new polyketides named fusarisolins F-K (1–6) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10).
Cankai Lin +9 more
doaj +1 more source
Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae [PDF]
, 2009 Aspergillus westerdijkiae is the main producer of several biologically active polyketide metabolites including isoasperlactone and asperlactone. A 5298 bp polyketide synthase gene ‘‘aomsas” has been cloned in Aspergillus westerdijkiae by using gene ...
Atoui, Ali +10 more
core +1 more source