Results 11 to 20 of about 39,295 (245)
Polyketide synthesis in vitro on a modular polyketide synthase [PDF]
Chemistry & Biology, 1995 The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated DEBS1-3). This complexity has hitherto frustrated mechanistic analysis of such enzymes.
Wiesmann, Kirsten E.H. +5 more
openaire +3 more sources
Acyltransferases as Tools for Polyketide Synthase Engineering [PDF]
Antibiotics, 2018 Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll +1 more
doaj +2 more sources
Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis [PDF]
Beilstein Journal of Organic Chemistry, 2013 Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes.
Stephan Klopries +2 more
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New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
Antibiotics, 2022 New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7), were isolated ...
Fuhang Song +5 more
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Hydrobiology, 2023 Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin and cyclo(Phe-Leu).
Hisayuki Komaki +2 more
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First Identification of Amphidinols from Mexican Strains and New Analogs
Toxins, 2023 The genus Amphidinium has been the subject of recent attention due to the production of polyketide metabolites. Some of these compounds have shown significant bioactivities and could be related to species interactions in the natural benthic ...
Lorena M. Durán-Riveroll +2 more
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Marine Drugs, 2023 Chemical epigenetic cultivation of the sponge-derived fungus Pestalotiopsis sp. SWMU-WZ04-1 contributed to the identification of twelve polyketide derivatives, including six new pestalotiopols E–J (1–6) and six known analogues (7–12).
Liyuan Jiang +7 more
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Heterocycles, 2007 I. Introduction 1. A Plethora of Polyketides: Structures, Biological Activities, and Enzymes - Scott R. Baerson and Agnes M. Rimando II. Polyketide Biosynthesis in Plants and Microorganisms 2. Hygromycin A Biosynthesis - Nadaraj Palaniappan and Kevin Reynolds 3. The Biosynthesis of Polyketides, Tetramic Acids and Pyridones in Fungi - Russell J.
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Frontiers in Plant Science, 2020 Extracellular vesicles (EVs) represent a system for the coordinated secretion of a variety of molecular cargo including proteins, lipids, nucleic acids, and metabolites.
Mark R. Bleackley +9 more
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Biosynthesis of Fungal Natural Products Involving Two Separate Pathway Crosstalk
Journal of Fungi, 2022 Fungal natural products (NPs) usually possess complicated structures, exhibit satisfactory bioactivities, and are an outstanding source of drug leads, such as the cholesterol-lowering drug lovastatin and the immunosuppressive drug mycophenolic acid.
Guangzhi Dai +3 more
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