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Microorganisms produce numerous secondary metabolites (SMs) with various biological activities. Many of their encoding gene clusters are silent under standard laboratory conditions because for their activation they need the ecological context, such as ...
Maria Cristina Stroe +6 more
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I. Introduction 1. A Plethora of Polyketides: Structures, Biological Activities, and Enzymes - Scott R. Baerson and Agnes M. Rimando II. Polyketide Biosynthesis in Plants and Microorganisms 2. Hygromycin A Biosynthesis - Nadaraj Palaniappan and Kevin Reynolds 3. The Biosynthesis of Polyketides, Tetramic Acids and Pyridones in Fungi - Russell J.
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The Toughest Material in the Plant Kingdom: An Update on Sporopollenin
The extreme chemical and physical recalcitrance of sporopollenin deems this biopolymer among the most resilient organic materials on Earth. As the primary material fortifying spore and pollen cell walls, sporopollenin is touted as a critical innovation ...
Etienne Grienenberger +1 more
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Actinomycetes are prolific producers of industrially valuable and medically important compounds. Historically, the most efficient method of obtaining compounds has been bioactivity-guided isolation and characterization of drug-like molecules from ...
Peng Hou +5 more
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Two new polyketide natural products, globosuxanthone F (1), and 2′-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3 ...
Jing Zhou +10 more
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Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery
The cellular slime mold Dictyostelium discoideum is an excellent model organism for the study of cell and developmental biology because of its simple life cycle and ease of use.
Yuzuru Kubohara, Haruhisa Kikuchi
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Three new tetronate-class polyketides, nomimicins B, C, and D, along with nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp.
Zhiwei Zhang +9 more
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Marine fungi-derived secondary metabolites are still an important source for the discovery of potential antimicrobial agents. Here, five new polyketides (1, 2, and 6–8) and seven known compounds (3–5 and 9–12) were obtained from the culture of the marine-
Changrong Lai +8 more
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Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388
Seven new polyketides named fusarisolins F-K (1–6) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10).
Cankai Lin +9 more
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A New Polyketide from the Endophytic Fungus Penicillium chermesinum
A new polyketide derivative, 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one (1), was isolated from the endophytic fungus Penicillium chermesinum.
Cici Darsih +4 more
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