Results 1 to 10 of about 10,782 (215)

Nonribosomal Peptide Synthesis Definitely Working Out of the Rules [PDF]

Microorganisms, 2022
Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields.
Matthieu Duban, Stéphane Cociancich, Valérie Leclère   +2 more
doaj   +4 more sources

Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis

Nature Communications, 2021
Nonribosomal lipopeptides contain an acyl chain important for bioactivity, but its incorporation into the peptidyl backbone, mediated by the starter condensation (Cs) domain of nonribosomal peptide synthases, is not fully understood.
Lin Zhong, Xiaotong Diao, Na Zhang, Fengwei Li, Haibo Zhou, Hanna Chen, Xianping Bai, Xintong Ren, Youming Zhang, Dalei Wu, Xiaoying Bian   +10 more
doaj   +2 more sources

Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases [PDF]

Marine Drugs
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang, Zijing Peng, Zhenkuai Huang, Jiaqi Fang, Xinhai Li, Xiaoting Qiu   +5 more
doaj   +2 more sources

Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells [PDF]

Beilstein Journal of Organic Chemistry
The adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins.
Fumihiro Ishikawa, Sho Konno, Hideaki Kakeya, Genzoh Tanabe   +3 more
doaj   +2 more sources

Discovery of Acyl-Surugamide A2 from Marine Streptomyces albidoflavus RKJM-0023—A New Cyclic Nonribosomal Peptide Containing an N-ε-acetyl-L-lysine Residue [PDF]

Molecules
We report the discovery of a novel cyclic nonribosomal peptide (NRP), acyl-surugamide A2, from a marine-derived Streptomyces albidoflavus RKJM-0023 (CP133227).
Zacharie A. Maw, Bradley Haltli, Jason J. Guo, Donna M. Baldisseri, Christopher Cartmell, Russell G. Kerr   +5 more
doaj   +2 more sources

BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure

Computational and Structural Biotechnology Journal, 2022
Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry N. Konanov, Danil V. Krivonos, Elena N. Ilina, Vladislav V. Babenko   +3 more
doaj   +1 more source

Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi

mSystems, 2021
Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell lysis,
Heiko T. Kiesewalter, Carlos N. Lozano-Andrade, Mario Wibowo, Mikael L. Strube, Gergely Maróti, Dan Snyder, Tue Sparholt Jørgensen, Thomas O. Larsen, Vaughn S. Cooper, Tilmann Weber, Ákos T. Kovács   +10 more
doaj   +1 more source

A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum. [PDF]

PLoS ONE, 2014
The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canonical
Hazrat Ali, Marco I Ries, Peter P Lankhorst, Rob A M van der Hoeven, Olaf L Schouten, Marek Noga, Thomas Hankemeier, Noël N M E van Peij, Roel A L Bovenberg, Rob J Vreeken, Arnold J M Driessen   +10 more
doaj   +1 more source

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin

Frontiers in Catalysis, 2023
In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Thierry Izoré, Thierry Izoré, Joe A. Kaczmarski, Joe A. Kaczmarski, Edward Marschall, Edward Marschall, Edward Marschall, Minuri S. Ratnayake, Minuri S. Ratnayake, Minuri S. Ratnayake, Julien Tailhades, Julien Tailhades, Julien Tailhades, David L. Steer, David L. Steer, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Max J. Cryle, Max J. Cryle, Max J. Cryle   +28 more
doaj   +1 more source

Biosynthesis and engineering of the nonribosomal peptides with a C-terminal putrescine

Nature Communications, 2023
The broad bioactivities of nonribosomal peptides rely on increasing structural diversity. Genome mining of the Burkholderiales strain Schlegelella brevitalea DSM 7029 leads to the identification of a class of dodecapeptides, glidonins, that feature ...
Hanna Chen, Lin Zhong, Haibo Zhou, Xianping Bai, Tao Sun, Xingyan Wang, Yiming Zhao, Xiaoqi Ji, Qiang Tu, Youming Zhang, Xiaoying Bian   +10 more
doaj   +1 more source