Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential [PDF]
Frontiers in Pharmacology, 2017 Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc.
Shivankar Agrawal +2 more
exaly +6 more sources
Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides [PDF]
Metabolites, 2020 Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources.
Yaojie Guo +2 more
exaly +5 more sources
rBAN: retro-biosynthetic analysis of nonribosomal peptides [PDF]
Journal of Cheminformatics, 2019 Proteinogenic and non-proteinogenic amino acids, fatty acids or glycans are some of the main building blocks of nonribsosomal peptides (NRPs) and as such may give insight into the origin, biosynthesis and bioactivities of their constitutive peptides ...
Emma Ricart +5 more
doaj +11 more sources
BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure [PDF]
Computational and Structural Biotechnology Journal, 2022 Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry N Konanov +2 more
exaly +4 more sources
Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides [PDF]
Microbial Cell Factories, 2021 As a robust, fast growing and genetically tractable organism, the budding yeast Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology.
Anna Tippelt, Markus Nett
doaj +3 more sources
Biosynthesis and engineering of the nonribosomal peptides with a C-terminal putrescine [PDF]
Nature Communications, 2023 The broad bioactivities of nonribosomal peptides rely on increasing structural diversity. Genome mining of the Burkholderiales strain Schlegelella brevitalea DSM 7029 leads to the identification of a class of dodecapeptides, glidonins, that feature ...
Hanna Chen +10 more
doaj +2 more sources
Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin [PDF]
PeerJ, 2015 Background. Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp.
Charlotte F. Michelsen +4 more
doaj +5 more sources
MassSpecBlocks: a web-based tool to create building blocks and sequences of nonribosomal peptides and polyketides for tandem mass spectra analysis [PDF]
Journal of Cheminformatics, 2021 Nonribosomal peptides and polyketides are natural products commonly synthesized by microorganisms. They are widely used in medicine, agriculture, environmental protection, and other fields.
Jan Přívratský, Jiří Novák
doaj +2 more sources
An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in
mBio, 2017 Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other.
Sara Cleto, Timothy K. Lu
doaj +2 more sources
Chemical structure metagenomics of microbial natural products: surveying nonribosomal peptides and beyond [PDF]
Beilstein Journal of Organic ChemistryBioactivity-guided fractionation (BGF) has historically been a fruitful natural product discovery workflow. However, it is plagued by increasing rediscovery rates in recent years and new methods capable of exploring the natural product chemical space ...
Thomas Ma, John Chu
doaj +2 more sources