BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure [PDF]
Computational and Structural Biotechnology Journal, 2022 Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry Konanov +2 more
exaly +4 more sources
Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides [PDF]
Metabolites, 2020 Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources.
Jens Frisvad +2 more
exaly +4 more sources
Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential [PDF]
Frontiers in Pharmacology, 2017 Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc.
Sunilkumar Deshmukh +2 more
exaly +4 more sources
Biosynthesis and engineering of the nonribosomal peptides with a C-terminal putrescine [PDF]
Nature Communications, 2023 The broad bioactivities of nonribosomal peptides rely on increasing structural diversity. Genome mining of the Burkholderiales strain Schlegelella brevitalea DSM 7029 leads to the identification of a class of dodecapeptides, glidonins, that feature ...
Hanna Chen +10 more
doaj +2 more sources
MassSpecBlocks: a web-based tool to create building blocks and sequences of nonribosomal peptides and polyketides for tandem mass spectra analysis [PDF]
Journal of Cheminformatics, 2021 Nonribosomal peptides and polyketides are natural products commonly synthesized by microorganisms. They are widely used in medicine, agriculture, environmental protection, and other fields.
Jan Přívratský, Jiří Novák
doaj +2 more sources
Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides [PDF]
Microbial Cell Factories, 2021 As a robust, fast growing and genetically tractable organism, the budding yeast Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology.
Anna Tippelt, Markus Nett
doaj +2 more sources
rBAN: retro-biosynthetic analysis of nonribosomal peptides [PDF]
Journal of Cheminformatics, 2019 Proteinogenic and non-proteinogenic amino acids, fatty acids or glycans are some of the main building blocks of nonribsosomal peptides (NRPs) and as such may give insight into the origin, biosynthesis and bioactivities of their constitutive peptides ...
Emma Ricart +5 more
doaj +2 more sources
An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in
mBio, 2017 Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other.
Sara Cleto, Timothy K. Lu
doaj +2 more sources
Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis [PDF]
Nature CommunicationsPolyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide ...
Munro Passmore +8 more
doaj +2 more sources
Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram-Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach. [PDF]
Adv Sci (Weinh)The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Chen K +9 more
europepmc +2 more sources