Results 31 to 40 of about 5,756 (191)

Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849^T

Fermentation, 2023
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has
Hisayuki Komaki, Tomohiko Tamura
doaj   +1 more source

Discovery and Heterologous Production of New Cyclic Depsibosamycins

Microorganisms, 2021
Streptomyces are producers of valuable secondary metabolites with unique scaffolds that perform a plethora of biological functions. Nonribosomal peptides are of special interest due to their variety and complexity.
Marc Stierhof, Maksym Myronovskyi, Josef Zapp, Andriy Luzhetskyy   +3 more
doaj   +1 more source

The Entomopathogenic Fungus Beauveria bassiana Shows Its Toxic Side within Insects: Expression of Genes Encoding Secondary Metabolites during Pathogenesis

Journal of Fungi, 2022
Entomopathogenic fungi are extensively used for the control of insect pests worldwide. Among them, Beauveria bassiana (Ascomycota: Hypocreales) produce a plethora of toxic secondary metabolites that either facilitate fungal invasion or act as ...
Nicolás Pedrini
doaj   +1 more source

Prediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery. [PDF]

PLoS ONE, 2014
Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide Synthetases (NRPSs), they often display complex ...
Thibault Caradec, Maude Pupin, Aurélien Vanvlassenbroeck, Marie-Dominique Devignes, Malika Smaïl-Tabbone, Philippe Jacques, Valérie Leclère   +6 more
doaj   +1 more source

Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092

Marine Drugs, 2018
Nonribosomal peptides from marine Bacillus strains have received considerable attention for their complex structures and potent bioactivities. In this study, we carried out PCR-based genome mining for potential nonribosomal peptides producers from our ...
Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma, Donghui Yang   +9 more
doaj   +1 more source

How to improve the production of peptidyl compounds in filamentous fungi

Frontiers in Fungal Biology, 2022
Peptidyl compounds produced by filamentous fungi, which are nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs), are rich sources of bioactive compounds with a wide variety of structures.
Maiko Umemura, Koichi Tamano, Koichi Tamano   +2 more
doaj   +1 more source

Nonribosomal Peptide Synthesis

, 2022
Nonribosomal peptides (NRPs) are a type of secondary metabolite with a wide range of pharmacological and biological activities including cytostatics, immunosuppressants or anticancer agents, antibiotics, pigments, siderophores, toxins. NRPs, unlike other proteins, are synthesized on huge nonribosomal peptide synthetase (NRPS) enzyme complexes that are ...
Sadık Dincer, Hatice Aysun Mercimek Takci, Melis Sumengen Ozdenefe   +2 more
openaire   +1 more source

Nonribosomal Peptide Synthesis and Toxigenicity of Cyanobacteria [PDF]

Journal of Bacteriology, 1999
ABSTRACT Nonribosomal peptide synthesis is achieved in prokaryotes and lower eukaryotes by the thiotemplate function of large, modular enzyme complexes known collectively as peptide synthetases. These and other multifunctional enzyme complexes, such as polyketide synthases, are of interest due to their use in unnatural-product or ...
B A, Neilan, E, Dittmann, L, Rouhiainen, R A, Bass, V, Schaub, K, Sivonen, T, Börner   +6 more
openaire   +2 more sources

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Metabolites, 2023
Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment.
Ana Ceniceros, Librada Cañedo, Carmen Méndez, Carlos Olano, Carmen Schleissner, Carmen Cuevas, Fernando de la Calle, José A. Salas   +7 more
doaj   +1 more source

Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains

, 2023
The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of amino acids for protein ...
Jaclyn, Winter, Stephanie , Heard
core   +1 more source