Results 51 to 60 of about 1,070,439 (189)

Nonribosomal Peptide Synthesis

, 2022
Nonribosomal peptides (NRPs) are a type of secondary metabolite with a wide range of pharmacological and biological activities including cytostatics, immunosuppressants or anticancer agents, antibiotics, pigments, siderophores, toxins. NRPs, unlike other proteins, are synthesized on huge nonribosomal peptide synthetase (NRPS) enzyme complexes that are ...
Sadık Dincer, Hatice Aysun Mercimek Takci, Melis Sumengen Ozdenefe   +2 more
openaire   +1 more source

How to improve the production of peptidyl compounds in filamentous fungi

Frontiers in Fungal Biology, 2022
Peptidyl compounds produced by filamentous fungi, which are nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs), are rich sources of bioactive compounds with a wide variety of structures.
Maiko Umemura, Koichi Tamano, Koichi Tamano   +2 more
doaj   +1 more source

Nonribosomal Peptide Synthesis and Toxigenicity of Cyanobacteria [PDF]

Journal of Bacteriology, 1999
ABSTRACT Nonribosomal peptide synthesis is achieved in prokaryotes and lower eukaryotes by the thiotemplate function of large, modular enzyme complexes known collectively as peptide synthetases. These and other multifunctional enzyme complexes, such as polyketide synthases, are of interest due to their use in unnatural-product or ...
B A, Neilan, E, Dittmann, L, Rouhiainen, R A, Bass, V, Schaub, K, Sivonen, T, Börner   +6 more
openaire   +2 more sources

Norine: A powerful resource for novel nonribosomal peptide discovery

Synthetic and Systems Biotechnology, 2016
Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://
M. Pupin, Q. Esmaeel, A. Flissi, Y. Dufresne, P. Jacques, V. Leclère   +5 more
doaj   +1 more source

Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

Nature Communications, 2021
The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans.
Likui Feng, Matthew T. Gordon, Ying Liu, Kari B. Basso, Rebecca A. Butcher   +4 more
doaj   +1 more source

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin

Frontiers in Catalysis, 2023
In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Thierry Izoré, Thierry Izoré, Joe A. Kaczmarski, Joe A. Kaczmarski, Edward Marschall, Edward Marschall, Edward Marschall, Minuri S. Ratnayake, Minuri S. Ratnayake, Minuri S. Ratnayake, Julien Tailhades, Julien Tailhades, Julien Tailhades, David L. Steer, David L. Steer, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Max J. Cryle, Max J. Cryle, Max J. Cryle   +28 more
doaj   +1 more source

Nonribosomal peptides in fungal cell factories: from genome mining to optimized heterologous production.

Biotechnology Advances, 2019
Fungi are notoriously prolific producers of secondary metabolites including nonribosomal peptides (NRPs). The structural complexity of NRPs grants them interesting activities such as antibiotic, anti-cancer, and anti-inflammatory properties.
Antoine Vassaux, L. Meunier, M. Vandenbol, D. Baurain, P. Fickers, P. Jacques, V. Leclère   +6 more
semanticscholar   +1 more source

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites

Biotechnology Reports, 2018
With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new
Zahid ur Rehman, Intikhab Alam, Allan Anthony Kamau, Vladimir B. Bajic, TorOve Leiknes   +4 more
doaj   +1 more source

Polyketide Synthase and Nonribosomal Peptide Synthetase Gene Clusters in Type Strains of the Genus Phytohabitans

Life, 2020
(1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites.
Hisayuki Komaki, Tomohiko Tamura
doaj   +1 more source