Results 61 to 70 of about 5,179 (121)

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

eLife, 2017
Nonribosomal peptides represent a large class of metabolites with pharmaceutical relevance. Pteridines, such as pterins, folates, and flavins, are heterocyclic metabolites that often serve as redox-active cofactors.
Hyun Bong Park, Corey E Perez, Karl W Barber, Jesse Rinehart, Jason M Crawford   +4 more
doaj   +1 more source

The Pharmacological Potential of Nonribosomal Peptides from Marine Sponge and Tunicates

Frontiers in Pharmacology, 2016
Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of
Shivankar Agrawal, Alok Adholeya, Sunil Kumar Deshmukh   +2 more
doaj   +1 more source

A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols

Marine Drugs
Peptaibols represent a large family of membrane-active, linear fungal peptides, with variable lengths from 5 to 21 α–amino acid residues. As products of nonribosomal peptide synthetase (NRPS) biosynthetic machinery, they encompass several non ...
Claudia Finamore, Carmen Festa, Mattia Cammarota, Simona De Marino, Maria Valeria D’Auria   +4 more
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, Volume 13, Issue 51, 14 September 2026.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Two New Polyketides From Streptomyces sp. SA61: Isolation, Structure Elucidation, and Insecticidal Activity Against Bemisia tabaci

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Isolation of six polyketides (including two new compounds, strekingmycins I and J) from earthworm gut‐derived Streptomyces sp. SA61 and their insecticidal activity against third‐instar nymphs of Bemisia tabaci. Strekingmycin A (1) exhibited the most potent activity (LC50 = 5.58 µg/mL), comparable to the commercial insecticide spirotetramat. ABSTRACT To
Pengfei Cui, Jiajun Chen, Zhaoyu Zhu, Fei Liu, Zhiguo Yu   +4 more
wiley   +1 more source

Endophytic Fungi Natural Factories of Novel Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review provides a systematic analysis of 242 natural products isolated from 42 genera of endophytic fungi, highlighting their remarkable structural diversity and broad spectrum of biological activities . ABSTRACT Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological ...
Dilmurod Murodullayev, Jakhongir Movlanov, Liu Wei, Wei Liu, Maksud Isokov, Santosh Kumar Bose, Fazliddin Kobilov, Zamira Djumayeva, Buston Islamov, Jamila Sherkulova, Zafar Matyakubov, Muniskhon Meylieva, Munisa Ergasheva, Diyor Abduraxmanov, Guozheng Huang, Hongchen Jiang, Kakhramon Davranov, Guohui Pan, Nigora Rustamova   +18 more
wiley   +1 more source

Bioactive Peptides Produced by Cyanobacteria of the Genus Nostoc: A Review

Marine Drugs, 2019
Cyanobacteria of the genus Nostoc are widespread in all kinds of habitats. They occur in a free-living state or in association with other organisms. Members of this genus belong to prolific producers of bioactive metabolites, some of which have been ...
Anna Fidor, Robert Konkel, Hanna Mazur-Marzec   +2 more
doaj   +1 more source

Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases

Marine Drugs
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang, Zijing Peng, Zhenkuai Huang, Jiaqi Fang, Xinhai Li, Xiaoting Qiu   +5 more
doaj   +1 more source

Anticancer Activity of Bacterial Proteins and Peptides

Pharmaceutics, 2018
Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute one of the main reasons of deaths worldwide. The side effects of chemotherapy and drug resistance of some cancer types belong to the significant current ...
Tomasz M. Karpiński, Artur Adamczak
doaj   +1 more source