Results 61 to 70 of about 1,070,439 (189)
Hydrobiology, 2023 Two Streptomyces strains, named N11-26 and DC10-5, were isolated from deep-sea and non-photosynthetic stony coral, respectively. Strain N11-26 produces lobophorin C and divergolides, which are antimicrobial substances.
Hisayuki Komaki +2 more
doaj +1 more source
Engineering DNA-Templated Nonribosomal Peptide Synthesis [PDF]
Cell Chemical Biology, 2020 Abstract Nanocontainers or macromolecular scaffolds for artificial biocatalytic cascades facilitate sequential enzyme reactions but diffusive escape of intermediates limits rate enhancement. Nonribosomal peptide synthetases (NRPS) naturally form gigantic assembly lines and prevent escape by covalently tethering intermediates.
Hsin-Mei Huang +2 more
openaire +2 more sources
Biologically Active Nonribosomal Peptides. III. Mechanism of Biosynthesis of Nonribosomal Peptides
Антибиотики и Химиотерапия, 2020 The third part of the review is concerned with investigation of nonribosomal peptides.
T. I. Orlova +2 more
doaj
Antifungal peptides in marine invertebrates [PDF]
Invertebrate Survival Journal, 2010 A majority of terrestrial and marine organisms use to fend off a wide range of microorganisms, including bacteria and fungi by employing “antimicrobial peptides (AMPs)” that are ribosomally synthesized from proteinogenic amino acids.
N Fusetani
doaj
Biologically Active Nonribosomal Peptides. II. Nonribosomal Peptides of Various Biological Action
Антибиотики и Химиотерапия, 2020 The second part of the review concerned with investigation of nonribosomal peptides.
T. I. Orlova +2 more
doaj
mSystems, 2021 Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell lysis,
Heiko T. Kiesewalter +10 more
doaj +1 more source
Piecing together nonribosomal peptide synthesis
Current Opinion in Structural Biology, 2018 Nonribosomal peptide synthetases (NRPSs) produce peptide products with wide-ranging biological activities. NRPSs are macromolecular machines with modular assembly-line logic, a complex catalytic cycle, moving parts and multiple active sites. They are organized into repeating sets of domains, called modules.
Reimer, Janice M. +3 more
openaire +3 more sources
Dissecting and Exploiting Nonribosomal Peptide Synthetases
Acta Biochimica et Biophysica Sinica, 2004 A large number of therapeutically useful cyclic and linear peptides of bacteria or fungal origin are synthesized via a template-directed, nucleic-acid-independent nonribosomal mechanism. This process is carried out by mega-enzymes called nonribosomal peptide synthetases (NRPSs).
Qing-Tao, Shen +3 more
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Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products
Synthetic and Systems Biotechnology, 2018 Natural products with significant biological activities continuously act as rich sources for drug discovery and development. To harness the potential of these valuable compounds, robust methods need to be developed for their rapid and sustainable ...
Jian Li, Lingkai Zhang, Wanqiu Liu
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Natural product reports (Print), 2023 Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural products, including antibiotics, siderophores, and molecules with other ...
K. Patel +4 more
semanticscholar +1 more source