Results 81 to 90 of about 5,756 (191)

Flexing and Stretching in Nonribosomal Peptide Synthetases

Chemistry & Biology, 2012
Re-engineering of nonribosomal peptide synthetase molecular assembly lines has been hampered by a lack of detailed knowledge concerning inter-domain substrate transfer. Recent structural studies of catalytically relevant domain-domain interactions provide valuable insights into this problem (Liu et al., 2011; Sundlov et al., 2012 [in this issue of ...
Pfennig, Sabrina, Stubbs, Milton T.
openaire   +2 more sources

Morphologic, Phylogenetic and Chemical Characterization of a Brackish Colonial Picocyanobacterium (Coelosphaeriaceae) with Bioactive Properties

Toxins, 2016
Despite their cosmopolitan distribution, knowledge on cyanobacteria in the family Coelosphaeriaceae is limited. In this study, a single species culture of a coelosphaeran cyanobacterium isolated from a brackish rock pool in the Baltic Sea was established.
Kerstin Häggqvist, Anna Toruńska-Sitarz, Agata Błaszczyk, Hanna Mazur-Marzec, Jussi Meriluoto   +4 more
doaj   +1 more source

Mechanistic analysis of nonribosomal peptide synthetases [PDF]

, 2021
Considering the ongoing rise of the multidrug-resistant bacterial infections, it is essential to expand the available repertoire of therapeutic agents.
Stanišić, Aleksa
core  

Antifungal peptides in marine invertebrates

Invertebrate Survival Journal, 2009
A majority of terrestrial and marine organisms use to fend off a wide range of microorganisms, including bacteria and fungi by employing “antimicrobial peptides (AMPs)” that are ribosomally synthesized from proteinogenic amino acids.
N Fusetani
doaj  

Structural basis of nonribosomal peptide macrocyclization in fungi [PDF]

Nature Chemical Biology, 2016
Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (CT) domain and the holo thiolation (T)-CT complex ...
Jinru, Zhang, Nicholas, Liu, Ralph A, Cacho, Zhou, Gong, Zhu, Liu, Wenming, Qin, Chun, Tang, Yi, Tang, Jiahai, Zhou   +8 more
openaire   +2 more sources

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, Volume 3, Issue 2, June 2026.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

[Biologically active nonribosomal peptides. II. Nonribosomal peptides of various biological action].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2012
The second part of the review concerned with investigation of nonribosomal peptides.
T. I. Orlova, V. G. Bulgakova, A. N. Polin   +2 more
openaire   +2 more sources

Pyoverdine Plays Only a Minor, Strain‐Specific Role in the Inhibition of Phytophthora infestans by Pseudomonas Strains

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Pseudomonas strains R32 and R47 inhibit Phytophthora infestans, which causes late blight in potato. To assess the importance of pyoverdine, a high‐affinity siderophore both strains produce, in P. infestans inhibition, we produced pyoverdine‐deficient mutants and tested their antagonistic activity at different developmental stages of the pathogen ...
Livia Jerjen, Floriane L'Haridon, Laure Weisskopf   +2 more
wiley   +1 more source

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis

Nature Communications
Polyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide ...
Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L. C. de los Santos, Douglas M. Roberts, Józef R. Lewandowski, Matthew Jenner, Lona M. Alkhalaf, Gregory L. Challis   +8 more
doaj   +1 more source

A Complete Genome Resource and Bio‐Control Activity of Soil‐Isolated Pseudomonas citronellolis Strain M03 Against Onion‐Pathogenic Burkholderia Species

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Pseudomonas citronellolis M03, isolated from field soil, was sequenced and its genome revealed ten biosynthetic clusters, including siderophore NRPS. Phenotypic assays showed strong antagonism against onion‐pathogenic Burkholderia spp., reducing B.
Kephas Mphande, Michelle Pena MacLellan, Anoop Anand Malik, Bhabesh Dutta   +3 more
wiley   +1 more source