Results 91 to 100 of about 5,756 (191)
New Plant Protection, Volume 3, Issue 2, June 2026.We developed a genome‐integrated CRISPR/Cas12a system for Xenorhabdus budapestensis XBD8, which enables precise deletion or replacement of DNA fragments ranging from 379 to 45,168 bp, with a success rate exceeding 90%. Application of this tool for the dynamic regulation of fabclavine‐8 biosynthesis resulted in a 1.90‐fold increase in production ...
Wenfeng Gan +4 more
wiley +1 more source
Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
Nature Communications, 2020 Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that ...
Mark J. Calcott +2 more
doaj +1 more source
Kineochelins—A New Group of Siderophores From an Antarctic Bacterium
Microbial Biotechnology, Volume 19, Issue 6, June 2026.Genome‐guided analysis of an Antarctic Actinokineospora strain led to the discovery of kineochelins, a new group of siderophores involved in iron sequestration and microbial competition. Kineochelin production inhibits co‐occurring bacteria and clinically relevant yeasts, highlighting Antarctic microorganisms as promising sources of bioactive natural ...
Stanislava Kralova +12 more
wiley +1 more source
, 1999 How genes are expressed and translated into proteins (using mRNA, codons and tRNAs as adaptor molecules) forms the basis of the ‘genetic code’. Many peptides are synthesized nonribosomally, however, by large protein complexes that also serve as templates.
Hans von Döhren +5 more
core +1 more source
Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.A novel mat‐forming benthic freshwater cyanobacterium, Limnofasciculus delicatus, is described based on morphological, phylogenetic and genomic evidence from the North and South Forks of the Shenandoah River. Although Limnofasciculus delicatus lacks biosynthetic gene clusters associated with the production of known cyanotoxins, it occurs in association
Rosalina Stancheva +5 more
wiley +1 more source
High mass accuracy analytical applications of Fourier transform ion cyclotron resonance mass spectrometry [PDF]
The performance capabilities of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry are higher than any other type of mass spectrometer, making this technique suitable for a range of analytical applications.
Wills, Rebecca Helen
core
Recent advances in engineering nonribosomal peptide assembly lines.
, 2016 Covering: up to July 2015Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications.
Winn, Michael +3 more
core +1 more source
eLife, 2017 Nonribosomal peptides represent a large class of metabolites with pharmaceutical relevance. Pteridines, such as pterins, folates, and flavins, are heterocyclic metabolites that often serve as redox-active cofactors.
Hyun Bong Park +4 more
doaj +1 more source
Development of a software platform for analysis of nonribosomal peptides
, 2009 Les peptides non-ribosomiaux sont des molécules produites par les micro-organismes et présentant un large éventail d’activités biologiques et pharmaceutiques.
Caboche, Ségolène
core
Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis
, 2022 Dehydroamino acids are important structural motifs and biosynthetic intermediates for natural products. Many bioactive natural products of nonribosomal origin contain dehydroamino acids; however, the biosynthesis of dehydroamino acids in most ...
Kamal Adhikari (9334450) +8 more
core +1 more source