Results 111 to 120 of about 5,756 (191)

Exploring the Role of Nonribosomal Peptides in the Human Microbiome Through the Oral Commensal Streptococcus mutans, the Probiotic Lactobacillus plantarum, and Crohn’s Disease Associated Faecalibacterium prausnitzii [PDF]

, 2012
Nonribosomal peptides, polyketides, and fatty acids comprise a distinct subset of microbial secondary metabolites produced by similar biosynthetic methods and exhibit broad structural diversity with a high propensity for biological activity.
Lukenda, Nikola
core  

RECONSTRUCTION OF AMINO ACID SEQUENCES OF CYCLIC PEPTIDES FROM THEIR MASS SPECTRA

Вавиловский журнал генетики и селекции, 2015
Mass spectrometry is a physical method, which can be applied to the investigation of proteomes of different organisms. It allows us both to solve the problem of identification of biological macromolecules and to sequence peptide chains in cases where ...
E. S. Fomin
doaj  

Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity

, 2012
Calcium-dependent antibiotics (CDA) are cyclic lipopeptides assembled by nonribosomal peptide synthetase (NRPS) enzymes. Active site modification of the 3-methyl glutamate activating adenylation (A) domain of the CDA NRPS enables the incorporation of ...
Nunns, L, Struck, A-W, Micklefield, J, Nunns, Laura, Majid Al Nakeeb, Laura Nunns, Struck, Anna Winona, Richard Lewis, Lewis, R, Thirlway, J, Styles, M, Colin P. Smith, Styles, Matthew, Anna‐Winona Struck, Al Nakeeb, Majid, Micklefield, Jason, Thirlway, Jenny, Jason Micklefield, Smith, CP, Lewis, Richard, Al Nakeeb, M, Smith, Colin P., Matthew Styles, Jenny Thirlway   +23 more
core   +1 more source

Discovery of a parallel family of euglenatide analogs in Euglena gracilis

Natural Products and Bioprospecting
The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis
Ahmed H. Elbanna, Xinhui Kou, Dilip V. Prajapati, Surasree Rakshit, Rebecca A. Butcher   +4 more
doaj   +1 more source

Novel Modifications of Nonribosomal Peptides from Brevibacillus laterosporus MG64 and Investigation of Their Mode of Action. [PDF]

Appl Environ Microbiol, 2020
Li Z, de Vries RH, Chakraborty P, Song C, Zhao X, Scheffers DJ, Roelfes G, Kuipers OP.   +7 more
europepmc   +1 more source

Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2

Cinnamoyl moiety containing nonribosomal peptides represented by pepticinnamin E are a growing family of natural products isolated from different Streptomyces species and possess diverse bioactivities.
Weber, Tilmann, Moreira, José M. A., Souza, Luciano D. O., Souza, Luciano D.O., Maleckis, Matiss, Ding, Ling, Mohamed, Manar Magdy Mahmoud, Abboud, Maria Mahmoud, Moreira, José M.A., Gotfredsen, Charlotte H.   +9 more
core   +1 more source

Nonribosomal peptide synthetases

, 2018
Nonribosomal peptide synthetases or NRPS, are extraordinarily large, modular and complex molecular machines responsible for the production of important bioactive compounds, such as antibiotics, anti-cancer drugs as well as pigments, among many others. Even though it has become increasingly simple to identify and partially classify this kind of enzyme ...
openaire   +1 more source

Single-molecule Study on the Interactions between Cyclic Nonribosomal Peptides and Protein Nanopore. [PDF]

ACS Appl Bio Mater, 2020
Zhou S, Wang H, Chen X, Wang Y, Zhou D, Liang L, Wang L, Wang D, Guan X.   +8 more
europepmc   +1 more source

INFORMATIC STRATEGIES AND TECHNOLOGIES FOR THE DIRECTED DISCOVERY OF NONRIBOSOMAL PEPTIDES

, 2014
Nonribosomal peptides (NRPs) are a major class of natural products known for their biological activities and are employed therapeutically as immunosupressants, anticancer agents, and antibiotics.
Wyatt, BM Aubrey
core  

Metabolomic-guided discovery of cyclic nonribosomal peptides from Xylaria ellisii sp. nov., a leaf and stem endophyte of Vaccinium angustifolium. [PDF]

Sci Rep, 2020
Ibrahim A, Tanney JB, Fei F, Seifert KA, Cutler GC, Capretta A, Miller JD, Sumarah MW.   +7 more
europepmc   +1 more source