Results 111 to 120 of about 1,070,439 (189)

Bioactive Peptides Produced by Cyanobacteria of the Genus Nostoc: A Review

Marine Drugs, 2019
Cyanobacteria of the genus Nostoc are widespread in all kinds of habitats. They occur in a free-living state or in association with other organisms. Members of this genus belong to prolific producers of bioactive metabolites, some of which have been ...
Anna Fidor, Robert Konkel, Hanna Mazur-Marzec   +2 more
doaj   +1 more source

Anticancer Activity of Bacterial Proteins and Peptides

Pharmaceutics, 2018
Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute one of the main reasons of deaths worldwide. The side effects of chemotherapy and drug resistance of some cancer types belong to the significant current ...
Tomasz M. Karpiński, Artur Adamczak
doaj   +1 more source

Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases

Marine Drugs
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang, Zijing Peng, Zhenkuai Huang, Jiaqi Fang, Xinhai Li, Xiaoting Qiu   +5 more
doaj   +1 more source

Nonribosomal peptides protect Pseudomonas nunensis 4A2e from amoebal and nematodal predation. [PDF]

Chem Sci, 2023
Pflanze S, Mukherji R, Ibrahim A, Günther M, Götze S, Chowdhury S, Reimer L, Regestein L, Stallforth P.   +8 more
europepmc   +1 more source

Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains

Natural product reports (Print)
Covering: 1997 to July 2023 The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of ...
S. Heard, Jaclyn M. Winter
semanticscholar   +1 more source

Bioinformatic Analysis Reveals both Oversampled and Underexplored Biosynthetic Diversity in Nonribosomal Peptides. [PDF]

ACS Chem Biol, 2023
Jian BS, Chiou SL, Hsu CC, Ho J, Wu YW, Chu J.   +5 more
europepmc   +1 more source

A niche-derived nonribosomal peptide triggers planarian sexual development

Proceedings of the National Academy of Sciences of the United States of America
Significance Throughout animals, germ cell development is regulated by extrinsic signals from somatic gonadal niche cells. Studies on traditional model organisms have shown that widely conserved signaling molecules, which activate developmental programs,
Melanie Issigonis, Katherine L. Browder, Rui Chen, James. J. Collins, P. Newmark   +4 more
semanticscholar   +1 more source

A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges*. [PDF]

Angew Chem Int Ed Engl, 2021
Ióca LP, Dai Y, Kunakom S, Diaz-Espinosa J, Krunic A, Crnkovic CM, Orjala J, Sanchez LM, Ferreira AG, Berlinck RGS, Eustáquio AS.   +10 more
europepmc   +1 more source

RECONSTRUCTION OF AMINO ACID SEQUENCES OF CYCLIC PEPTIDES FROM THEIR MASS SPECTRA

Вавиловский журнал генетики и селекции, 2015
Mass spectrometry is a physical method, which can be applied to the investigation of proteomes of different organisms. It allows us both to solve the problem of identification of biological macromolecules and to sequence peptide chains in cases where ...
E. S. Fomin
doaj  

Discovery of a parallel family of euglenatide analogs in Euglena gracilis

Natural Products and Bioprospecting
The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis
Ahmed H. Elbanna, Xinhui Kou, Dilip V. Prajapati, Surasree Rakshit, Rebecca A. Butcher   +4 more
doaj   +1 more source