The Pharmacological Potential of Nonribosomal Peptides from Marine Sponge and Tunicates
Frontiers in Pharmacology, 2016 Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of
Shivankar Agrawal +2 more
doaj +1 more source
Novel chemical probes for the investigation of nonribosomal peptide assembly [PDF]
, 2017 Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights
Manuela Tosin +29 more
core +1 more source
Bioactive Peptides Produced by Cyanobacteria of the Genus Nostoc: A Review
Marine Drugs, 2019 Cyanobacteria of the genus Nostoc are widespread in all kinds of habitats. They occur in a free-living state or in association with other organisms. Members of this genus belong to prolific producers of bioactive metabolites, some of which have been ...
Anna Fidor +2 more
doaj +1 more source
Anticancer Activity of Bacterial Proteins and Peptides
Pharmaceutics, 2018 Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute one of the main reasons of deaths worldwide. The side effects of chemotherapy and drug resistance of some cancer types belong to the significant current ...
Tomasz M. Karpiński, Artur Adamczak
doaj +1 more source
Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases
Marine DrugsNonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang +5 more
doaj +1 more source
Nonribosomal peptides protect Pseudomonas nunensis 4A2e from amoebal and nematodal predation. [PDF]
Chem Sci, 2023 Pflanze S +8 more
europepmc +1 more source
Bioinformatic Analysis Reveals both Oversampled and Underexplored Biosynthetic Diversity in Nonribosomal Peptides. [PDF]
ACS Chem Biol, 2023 Jian BS +5 more
europepmc +1 more source
Reengineering and Discovery of Nonribosomal Peptide Synthetases
, 2010 Nonribosomal peptides are an important class of natural products including the life-saving antibiotics penicillin and vancomycin and the deadly microcystins and cereulide. This important category of natural products is thus a focus of many research labs
Evans, Bradley S.
core
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides
The modular nature of nonribosomal peptide biosynthesis has driven efforts to generate peptide analogs by substituting amino acid-specifying domains within nonribosomal peptide synthetase (NRPS) enzymes. Rational NRPS engineering has increasingly focused
Mark Calcott (8511330) +6 more
core +1 more source
A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges*. [PDF]
Angew Chem Int Ed Engl, 2021 Ióca LP +10 more
europepmc +1 more source