Results 41 to 50 of about 5,756 (191)

Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

Nature Communications, 2021
The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans.
Likui Feng, Matthew T. Gordon, Ying Liu, Kari B. Basso, Rebecca A. Butcher   +4 more
doaj   +1 more source

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin

Frontiers in Catalysis, 2023
In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Thierry Izoré, Thierry Izoré, Joe A. Kaczmarski, Joe A. Kaczmarski, Edward Marschall, Edward Marschall, Edward Marschall, Minuri S. Ratnayake, Minuri S. Ratnayake, Minuri S. Ratnayake, Julien Tailhades, Julien Tailhades, Julien Tailhades, David L. Steer, David L. Steer, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Max J. Cryle, Max J. Cryle, Max J. Cryle   +28 more
doaj   +1 more source

Mimicking Nonribosomal Peptides from the Marine Actinomycete Streptomyces sp. H‑KF8 Leads to Antimicrobial Peptides

, 2023
Microorganisms within the marine environment have been shown to be very effective sources of naturally produced antimicrobial peptides (AMPs). Several nonribosomal peptides were identified based on genome mining predictions of Streptomyces sp.
Beatriz Cámara (17674916), Luisa I. Beyer (17674910), Ann-Britt Schäfer (14424495), Elin Svensson (2567467), Alesia A. Tietze (4220407), Michaela Wenzel (1933600), Daniel Tietze (1602613), Agustina Undabarrena (9575414), Inger Mattsby-Baltzer (17674913), Alexandra Stubelius (5957825)   +9 more
core   +1 more source

Engineering DNA-Templated Nonribosomal Peptide Synthesis [PDF]

Cell Chemical Biology, 2020
Abstract Nanocontainers or macromolecular scaffolds for artificial biocatalytic cascades facilitate sequential enzyme reactions but diffusive escape of intermediates limits rate enhancement. Nonribosomal peptide synthetases (NRPS) naturally form gigantic assembly lines and prevent escape by covalently tethering intermediates.
Hsin-Mei Huang, Philipp Stephan, Hajo Kries   +2 more
openaire   +2 more sources

Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites

Biotechnology Reports, 2018
With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new
Zahid ur Rehman, Intikhab Alam, Allan Anthony Kamau, Vladimir B. Bajic, TorOve Leiknes   +4 more
doaj   +1 more source

Polyketide Synthase and Nonribosomal Peptide Synthetase Gene Clusters in Type Strains of the Genus Phytohabitans

Life, 2020
(1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites.
Hisayuki Komaki, Tomohiko Tamura
doaj   +1 more source

Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. [PDF]

Nat Chem Biol, 2012
Cyclization of linear peptidyl precursors produced by nonribosomal peptide synthetases (NRPSs) is an important step in the biosynthesis of bioactive cyclic peptides. Whereas bacterial NRPSs use thioesterase (TE) domains to perform the cyclization, fungal
Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y.   +6 more
europepmc   +2 more sources

Classification and Secondary Metabolite-Biosynthetic Gene Clusters of Marine Streptomyces Strains Including a Lobophorin- and Divergolide-Producer

Hydrobiology, 2023
Two Streptomyces strains, named N11-26 and DC10-5, were isolated from deep-sea and non-photosynthetic stony coral, respectively. Strain N11-26 produces lobophorin C and divergolides, which are antimicrobial substances.
Hisayuki Komaki, Tomohiko Tamura, Yasuhiro Igarashi   +2 more
doaj   +1 more source

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: Using structural genomics tools for a challenging target

, 2010
Nonribosomal peptide synthetases (NRPSs) are large multimodular and multidomain enzymes that are involved in synthesising an array of molecules that are important in human and animal health.
Lee, TV, Arcus, VL, Lott, JS, Johnson, RD, Lott, J. Shaun, Vickery L. Arcus, Johnson, Richard D., Arcus, Vickery L., J. Shaun Lott, Richard D. Johnson, T. Verne Lee, Lee, T. Verne   +11 more
core   +1 more source

Biologically Active Nonribosomal Peptides. III. Mechanism of Biosynthesis of Nonribosomal Peptides

Антибиотики и Химиотерапия, 2020
The third part of the review is concerned with investigation of nonribosomal peptides.
T. I. Orlova, V. G. Bulgakova, A. N. Polin   +2 more
doaj