Results 41 to 50 of about 1,070,439 (189)

Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849^T

Fermentation, 2023
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has
Hisayuki Komaki, Tomohiko Tamura
doaj   +1 more source

Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery. [PDF]

Proc Natl Acad Sci U S A, 2012
Ibrahim A, Yang L, Johnston C, Liu X, Ma B, Magarvey NA.   +5 more
europepmc   +2 more sources

NORINE: a database of nonribosomal peptides [PDF]

Nucleic Acids Research, 2007
Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs).
Caboche, Ségolène, Pupin, Maude, Leclère, Valérie, Fontaine, Arnaud, Jacques, Philippe, Kucherov, Gregory   +5 more
openaire   +4 more sources

Media development and process parameter optimization using statistical experimental designs for the production of nonribosomal peptides in Escherichia coli

Electronic Journal of Biotechnology, 2021
Background: Nonribosomal peptide synthases (NRPS) can synthesize functionally diverse bioactive peptides by incorporating nonproteinogenic amino acids, offering a rich source of new drug leads.
Arne Michael Oestreich, Merlinda Ilire Suli, Doreen Gerlach, Rong Fan, Peter Czermak   +4 more
doaj   +1 more source

Discovery and Heterologous Production of New Cyclic Depsibosamycins

Microorganisms, 2021
Streptomyces are producers of valuable secondary metabolites with unique scaffolds that perform a plethora of biological functions. Nonribosomal peptides are of special interest due to their variety and complexity.
Marc Stierhof, Maksym Myronovskyi, Josef Zapp, Andriy Luzhetskyy   +3 more
doaj   +1 more source

The Entomopathogenic Fungus Beauveria bassiana Shows Its Toxic Side within Insects: Expression of Genes Encoding Secondary Metabolites during Pathogenesis

Journal of Fungi, 2022
Entomopathogenic fungi are extensively used for the control of insect pests worldwide. Among them, Beauveria bassiana (Ascomycota: Hypocreales) produce a plethora of toxic secondary metabolites that either facilitate fungal invasion or act as ...
Nicolás Pedrini
doaj   +1 more source

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases

Nature Communications, 2017
Nonribosomal peptides are important bioactive molecules that are synthetized by enzymes containing several catalytic domains. Here the authors describe the catalytic mechanism of fungal nonribosomal peptide synthetases and present an approach to modify ...
Dayu Yu, Fuchao Xu, Shuwei Zhang, Jixun Zhan   +3 more
doaj   +1 more source

Prediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery. [PDF]

PLoS ONE, 2014
Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide Synthetases (NRPSs), they often display complex ...
Thibault Caradec, Maude Pupin, Aurélien Vanvlassenbroeck, Marie-Dominique Devignes, Malika Smaïl-Tabbone, Philippe Jacques, Valérie Leclère   +6 more
doaj   +1 more source

Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092

Marine Drugs, 2018
Nonribosomal peptides from marine Bacillus strains have received considerable attention for their complex structures and potent bioactivities. In this study, we carried out PCR-based genome mining for potential nonribosomal peptides producers from our ...
Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma, Donghui Yang   +9 more
doaj   +1 more source

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Metabolites, 2023
Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment.
Ana Ceniceros, Librada Cañedo, Carmen Méndez, Carlos Olano, Carmen Schleissner, Carmen Cuevas, Fernando de la Calle, José A. Salas   +7 more
doaj   +1 more source