Results 41 to 50 of about 5,179 (121)

Biologically Active Nonribosomal Peptides. II. Nonribosomal Peptides of Various Biological Action

Антибиотики и Химиотерапия, 2020
The second part of the review concerned with investigation of nonribosomal peptides.
T. I. Orlova, V. G. Bulgakova, A. N. Polin   +2 more
doaj  

Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi

mSystems, 2021
Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell lysis,
Heiko T. Kiesewalter, Carlos N. Lozano-Andrade, Mario Wibowo, Mikael L. Strube, Gergely Maróti, Dan Snyder, Tue Sparholt Jørgensen, Thomas O. Larsen, Vaughn S. Cooper, Tilmann Weber, Ákos T. Kovács   +10 more
doaj   +1 more source

Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products

Synthetic and Systems Biotechnology, 2018
Natural products with significant biological activities continuously act as rich sources for drug discovery and development. To harness the potential of these valuable compounds, robust methods need to be developed for their rapid and sustainable ...
Jian Li, Lingkai Zhang, Wanqiu Liu
doaj   +1 more source

Small Spatial Scale Drivers of Secondary Metabolite Biosynthetic Diversity in Environmental Microbiomes

mSystems, 2023
In the search for novel drug candidates, diverse environmental microbiomes have been surveyed for their secondary metabolite biosynthesis potential, yet little is known about the biosynthetic diversity encoded by divergent microbiomes from different ...
Aileen Ute Geers, Mikael Lenz Strube, Mikkel Bentzon-Tilia   +2 more
doaj   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Surveying the potential of secreted antimicrobial peptides to enhance plant disease resistance.

Frontiers in Plant Science, 2015
Antimicrobial peptides (AMPs) are natural products found across diverse taxa as part of the innate immune system against pathogen attacks. Some AMPs are synthesised through the canonical gene expression machinery and are called ribosomal AMPs. Other AMPs
Susan eBreen, Peter eSolomon, Frank eBedon, Frank eBedon, Delphine eVincent   +4 more
doaj   +1 more source

Mining the Yucatan Coastal Microbiome for the Identification of Non-Ribosomal Peptides Synthetase (NRPS) Genes

Toxins, 2020
Prokaryotes represent a source of both biotechnological and pharmaceutical molecules of importance, such as nonribosomal peptides (NRPs). NRPs are secondary metabolites which their synthesis is independent of ribosomes.
Mario Alberto Martínez-Núñez, Zuemy Rodríguez-Escamilla   +1 more
doaj   +1 more source

Sulfur-Containing Compounds from Endophytic Fungi: Sources, Structures and Bioactivities

Journal of Fungi, 2022
Endophytic fungi have attracted increasing attention as an under-explored source for the discovery and development of structurally and functionally diverse secondary metabolites.
Yaqin Fan, Zhiheng Ma, Yan Zhang, Yufei Wang, Yousong Ding, Cong Wang, Shugeng Cao   +6 more
doaj   +1 more source

Epoxinnamide: An Epoxy Cinnamoyl-Containing Nonribosomal Peptide from an Intertidal Mudflat-Derived Streptomyces sp.

Marine Drugs, 2022
Cinnamoyl-containing nonribosomal peptides (CCNPs) form a unique family of actinobacterial secondary metabolites and display various biological activities.
Sangwook Kang, Jaeho Han, Sung Chul Jang, Joon Soo An, Ilnam Kang, Yun Kwon, Sang-Jip Nam, Sang Hee Shim, Jang-Cheon Cho, Sang Kook Lee, Dong-Chan Oh   +10 more
doaj   +1 more source

Morphologic, Phylogenetic and Chemical Characterization of a Brackish Colonial Picocyanobacterium (Coelosphaeriaceae) with Bioactive Properties

Toxins, 2016
Despite their cosmopolitan distribution, knowledge on cyanobacteria in the family Coelosphaeriaceae is limited. In this study, a single species culture of a coelosphaeran cyanobacterium isolated from a brackish rock pool in the Baltic Sea was established.
Kerstin Häggqvist, Anna Toruńska-Sitarz, Agata Błaszczyk, Hanna Mazur-Marzec, Jussi Meriluoto   +4 more
doaj   +1 more source