MassSpecBlocks: a web-based tool to create building blocks and sequences of nonribosomal peptides and polyketides for tandem mass spectra analysis [PDF]
Journal of Cheminformatics, 2021 Nonribosomal peptides and polyketides are natural products commonly synthesized by microorganisms. They are widely used in medicine, agriculture, environmental protection, and other fields.
Jan Přívratský, Jiří Novák
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Metabolomic-guided discovery of cyclic nonribosomal peptides from Xylaria ellisii sp. nov., a leaf and stem endophyte of Vaccinium angustifolium. [PDF]
Sci Rep, 2020 Fungal endophytes are sources of novel bioactive compounds but relatively few agriculturally important fruiting plants harboring endophytes have been carefully studied.
Ibrahim A +7 more
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Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining. [PDF]
Nat Commun, 2018 The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted
Li YX, Zhong Z, Zhang WP, Qian PY.
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Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study. [PDF]
Curr Opin Struct Biol, 2018 Microbes synthesize small, iron-chelating molecules known as siderophores to acquire iron from the environment. One way siderophores are generated is by nonribosomal peptide synthetases (NRPSs).
Ronnebaum TA, Lamb AL.
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Nonribosomal Peptide Synthesis Definitely Working Out of the Rules
Microorganisms, 2022 Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields.
Matthieu Duban +2 more
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Nonribosomal peptides, key biocontrol components for Pseudomonas fluorescens In5, isolated from a Greenlandic suppressive soil. [PDF]
mBio, 2015 Potatoes are cultivated in southwest Greenland without the use of pesticides and with limited crop rotation. Despite the fact that plant-pathogenic fungi are present, no severe-disease outbreaks have yet been observed.
Michelsen CF +6 more
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An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in
mBio, 2017 Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other.
Sara Cleto, Timothy K. Lu
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Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. [PDF]
Nat Chem Biol, 2012 Cyclization of linear peptidyl precursors produced by nonribosomal peptide synthetases (NRPSs) is an important step in the biosynthesis of bioactive cyclic peptides. Whereas bacterial NRPSs use thioesterase (TE) domains to perform the cyclization, fungal
Gao X +6 more
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Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin [PDF]
PeerJ, 2015 Background. Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp.
Charlotte F. Michelsen +4 more
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ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides. [PDF]
J Biol Chem, 2011 The pks genomic island of Escherichia coli encodes polyketide (PK) and nonribosomal peptide (NRP) synthases that allow assembly of a putative hybrid PK-NRP compound named colibactin that induces DNA double-strand breaks in eukaryotic cells.
Dubois D +10 more
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