Results 21 to 30 of about 5,179 (121)

Discovery and Heterologous Production of New Cyclic Depsibosamycins

Microorganisms, 2021
Streptomyces are producers of valuable secondary metabolites with unique scaffolds that perform a plethora of biological functions. Nonribosomal peptides are of special interest due to their variety and complexity.
Marc Stierhof, Maksym Myronovskyi, Josef Zapp, Andriy Luzhetskyy   +3 more
doaj   +1 more source

The Entomopathogenic Fungus Beauveria bassiana Shows Its Toxic Side within Insects: Expression of Genes Encoding Secondary Metabolites during Pathogenesis

Journal of Fungi, 2022
Entomopathogenic fungi are extensively used for the control of insect pests worldwide. Among them, Beauveria bassiana (Ascomycota: Hypocreales) produce a plethora of toxic secondary metabolites that either facilitate fungal invasion or act as ...
Nicolás Pedrini
doaj   +1 more source

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases

Nature Communications, 2017
Nonribosomal peptides are important bioactive molecules that are synthetized by enzymes containing several catalytic domains. Here the authors describe the catalytic mechanism of fungal nonribosomal peptide synthetases and present an approach to modify ...
Dayu Yu, Fuchao Xu, Shuwei Zhang, Jixun Zhan   +3 more
doaj   +1 more source

Prediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery. [PDF]

PLoS ONE, 2014
Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide Synthetases (NRPSs), they often display complex ...
Thibault Caradec, Maude Pupin, Aurélien Vanvlassenbroeck, Marie-Dominique Devignes, Malika Smaïl-Tabbone, Philippe Jacques, Valérie Leclère   +6 more
doaj   +1 more source

Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092

Marine Drugs, 2018
Nonribosomal peptides from marine Bacillus strains have received considerable attention for their complex structures and potent bioactivities. In this study, we carried out PCR-based genome mining for potential nonribosomal peptides producers from our ...
Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma, Donghui Yang   +9 more
doaj   +1 more source

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Metabolites, 2023
Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment.
Ana Ceniceros, Librada Cañedo, Carmen Méndez, Carlos Olano, Carmen Schleissner, Carmen Cuevas, Fernando de la Calle, José A. Salas   +7 more
doaj   +1 more source

How to improve the production of peptidyl compounds in filamentous fungi

Frontiers in Fungal Biology, 2022
Peptidyl compounds produced by filamentous fungi, which are nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs), are rich sources of bioactive compounds with a wide variety of structures.
Maiko Umemura, Koichi Tamano, Koichi Tamano   +2 more
doaj   +1 more source

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Norine: A powerful resource for novel nonribosomal peptide discovery

Synthetic and Systems Biotechnology, 2016
Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://
M. Pupin, Q. Esmaeel, A. Flissi, Y. Dufresne, P. Jacques, V. Leclère   +5 more
doaj   +1 more source

Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

Nature Communications, 2021
The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans.
Likui Feng, Matthew T. Gordon, Ying Liu, Kari B. Basso, Rebecca A. Butcher   +4 more
doaj   +1 more source