Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides [PDF]
Metabolites, 2021 Olga Kunyavskaya +2 more
exaly +2 more sources
A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols [PDF]
Marine DrugsPeptaibols represent a large family of membrane-active, linear fungal peptides, with variable lengths from 5 to 21 α–amino acid residues. As products of nonribosomal peptide synthetase (NRPS) biosynthetic machinery, they encompass several non ...
Claudia Finamore +4 more
doaj +2 more sources
Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated Paenibacillus species [PDF]
mSystemsThe growing threat of antimicrobial resistance necessitates the discovery of novel antibiotics with activity against drug-resistant pathogens. Members of the genus Paenibacillus are a rich source of nonribosomal peptides (NRPs), including well-known ...
Nataliia V. Machushynets +9 more
doaj +2 more sources
Mimicking Nonribosomal Peptides from the Marine Actinomycete Streptomyces sp. H-KF8 Leads to Antimicrobial Peptides. [PDF]
ACS Infect Dis, 2023 Microorganisms within the marine environment have been shown to be very effective sources of naturally produced antimicrobial peptides (AMPs). Several nonribosomal peptides were identified based on genome mining predictions of Streptomyces sp.
Beyer LI +9 more
europepmc +2 more sources
Nonribosomal Peptide Synthetases in Animals
Genes, 2023 Nonribosomal peptide synthetases (NRPSs) are a class of cytosolic enzymes that synthesize a range of bio-active secondary metabolites including antibiotics and siderophores. They are widespread among both prokaryotes and eukaryotes but are considered rare among animals.
Wouter Suring +5 more
openaire +3 more sources
Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics
Journal of Fungi, 2021 Previously, DNA microarrays analysis showed that, in co-culture with Bacillus subtilis, a biosynthetic gene cluster anchored with a nonribosomal peptides synthetase of Aspergillus niger is downregulated.
Gregory Evdokias +7 more
doaj +1 more source
A strategy for the identification of patterns in the biosynthesis of nonribosomal peptides by Betaproteobacteria species. [PDF]
Sci Rep, 2017 Nonribosomal peptides have an important pharmacological role due to their extensive biological properties. The singularities in the biosynthesis of these natural products allowed the development of genome-mining strategies which associate them to their ...
Baldim JL +4 more
europepmc +2 more sources
Biosynthetic Functionalization of Nonribosomal Peptides
Journal of the American Chemical Society, 2021 Nonribosomal peptides (NRPs) are a therapeutically important class of secondary metabolites that are produced by modular synthetases in assembly-line fashion. We previously showed that a single Trp-to-Ser mutation in the initial Phe-loading adenylation domain of tyrocidine synthetase completely switches the specificity toward clickable analogues.
David L. Niquille +3 more
openaire +3 more sources
A Nonribosomal System of Peptide Biosynthesis [PDF]
European Journal of Biochemistry, 1996 This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures.
H, Kleinkauf, H, Von Döhren
openaire +2 more sources
Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining. [PDF]
Nat Commun, 2018 The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted
Li YX, Zhong Z, Zhang WP, Qian PY.
europepmc +3 more sources