Results 11 to 20 of about 5,756 (191)
Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains [PDF]
ChemBioChem, 2020 Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from
Helge B Bode
exaly +3 more sources
NORINE: a database of nonribosomal peptides. [PDF]
Nucleic Acids Research, 2008 peer reviewedNorine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows ...
Caboche, Segolene +5 more
core +6 more sources
A new fingerprint to predict nonribosomal peptides activity [PDF]
Journal of Computer-Aided Molecular Design, 2012 peer reviewedBacteria and fungi use a set of enzymes called nonribosomal peptide synthetases to provide a wide range of natural peptides displaying structural and biological diversity.
Ammar Abdo +2 more
exaly +4 more sources
, 2009 Nonribosomal peptides are a diverse group of compounds synthesized via modular nonribosomal peptide synthetase (NRPS) enzyme complexes. They are produced by a variety of prokaryotes, including streptomycetes, bacillus, and cyanobacteria, and lower-order ...
Roberts, Alexandra A. +5 more
core +4 more sources
Electronic Journal of Biotechnology, 2021 Background: Nonribosomal peptide synthases (NRPS) can synthesize functionally diverse bioactive peptides by incorporating nonproteinogenic amino acids, offering a rich source of new drug leads.
Arne Michael Oestreich +4 more
doaj +3 more sources
Engineering the biosynthesis of fungal nonribosomal peptides
Natural Product Reports, 2022 Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the related polyketide-nonribosomal peptide hybrid products (PK-NRPs) are a prolific source of bioactive compounds, some of which have been developed into essential drugs.
Zhong, Weimao +5 more
core +4 more sources
Nonribosomal Peptide Synthesis Definitely Working Out of the Rules [PDF]
Microorganisms, 2022 Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields.
Matthieu Duban +2 more
doaj +2 more sources
Norine: A powerful resource for novel nonribosomal peptide discovery [PDF]
Synthetic and Systems Biotechnology, 2016 Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://
M. Pupin +5 more
doaj +2 more sources
Decoding and reprogramming fungal iterative nonribosomal peptide synthetases
Nature Communications, 2017 Nonribosomal peptides are important bioactive molecules that are synthetized by enzymes containing several catalytic domains. Here the authors describe the catalytic mechanism of fungal nonribosomal peptide synthetases and present an approach to modify ...
Dayu Yu +3 more
doaj +2 more sources
Emulating nonribosomal peptides with ribosomal biosynthetic strategies. [PDF]
RSC Chem Biol, 2023 This review compares structural features common to both nonribosomal and ribosomally synthesised and posttranslationally modified peptides and describes recent advances for using the RiPP technology to mimic nonribosomal ...
Mordhorst S +4 more
europepmc +2 more sources