Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides [PDF]
Metabolites, 2021 Microbial natural products are a major source of bioactive compounds for drug discovery. Among these molecules, nonribosomal peptides (NRPs) represent a diverse class of natural products that include antibiotics, immunosuppressants, and anticancer agents.
Mauricio Caraballo +2 more
exaly +5 more sources
Biosynthesis and engineering of the nonribosomal peptides with a C-terminal putrescine [PDF]
Nature Communications, 2023 The broad bioactivities of nonribosomal peptides rely on increasing structural diversity. Genome mining of the Burkholderiales strain Schlegelella brevitalea DSM 7029 leads to the identification of a class of dodecapeptides, glidonins, that feature ...
Hanna Chen +10 more
doaj +3 more sources
Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides [PDF]
Microbial Cell Factories, 2021 As a robust, fast growing and genetically tractable organism, the budding yeast Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology.
Anna Tippelt, Markus Nett
doaj +3 more sources
BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure [PDF]
Computational and Structural Biotechnology Journal, 2022 Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry Konanov +2 more
exaly +4 more sources
Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides [PDF]
Metabolites, 2020 Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources.
Jens Frisvad +2 more
exaly +4 more sources
rBAN: retro-biosynthetic analysis of nonribosomal peptides [PDF]
Journal of Cheminformatics, 2019 Proteinogenic and non-proteinogenic amino acids, fatty acids or glycans are some of the main building blocks of nonribsosomal peptides (NRPs) and as such may give insight into the origin, biosynthesis and bioactivities of their constitutive peptides ...
Emma Ricart +5 more
doaj +3 more sources
Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains [PDF]
ChemBioChem, 2020 Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from
Helge B Bode
exaly +3 more sources
A new fingerprint to predict nonribosomal peptides activity [PDF]
Journal of Computer-Aided Molecular Design, 2012 Bacteria and fungi use a set of enzymes called nonribosomal peptide synthetases to provide a wide range of natural peptides displaying structural and biological diversity. So, nonribosomal peptides (NRPs) are the basis for some efficient drugs.
Valerie Leclere, , Philippe Jacques
exaly +3 more sources
Emulating nonribosomal peptides with ribosomal biosynthetic strategies. [PDF]
RSC Chem Biol, 2023 Peptide natural products are important lead structures for human drugs and many nonribosomal peptides possess antibiotic activity. This makes them interesting targets for engineering approaches to generate peptide analogues with, for example, increased ...
Mordhorst S +4 more
europepmc +2 more sources
Biosynthetic Functionalization of Nonribosomal Peptides.
Journal of the American Chemical Society, 2021 Nonribosomal peptides (NRPs) are a therapeutically important class of secondary metabolites that are produced by modular synthetases in assembly-line fashion.
David L. Niquille +3 more
semanticscholar +4 more sources