Results 11 to 20 of about 5,179 (121)

Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin [PDF]

PeerJ, 2015
Background. Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp.
Charlotte F. Michelsen, Helle Jensen, Vincent J. Venditto, Rosanna C. Hennessy, Peter Stougaard   +4 more
doaj   +3 more sources

Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides [PDF]

Metabolites, 2021
Mauricio Caraballo, Louis-Félix Nothias, Olga Kunyavskaya   +2 more
exaly   +2 more sources

Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr-Pyrazole Chemistry. [PDF]

ChemMedChem
The glycopeptide antibiotics (GPAs) are important clinical antibiotics. While chemoenzymatic synthesis of more hydrophilic GPAs like vancomycin has aided our understanding of GPA crosslinking, hydrophobic GPAs remain underexplored. Here, we show that modified Knorr‐pyrazole chemistry improves access to hydrophobic peptidyl‐CoAs, with such substrates ...
Gullick J, Weerasinghe WRH, Schittenhelm RB, Tailhades J, Cryle MJ.   +4 more
europepmc   +2 more sources

Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated Paenibacillus species [PDF]

mSystems
The growing threat of antimicrobial resistance necessitates the discovery of novel antibiotics with activity against drug-resistant pathogens. Members of the genus Paenibacillus are a rich source of nonribosomal peptides (NRPs), including well-known ...
Nataliia V. Machushynets, Somayah S. Elsayed, Chao Du, Vladyslav Lysenko, Mercedes de la Cruz, Pilar Sanchez, Olga Genilloud, Nathaniel I. Martin, Mark R. Liles, Gilles P. van Wezel   +9 more
doaj   +2 more sources

Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains [PDF]

ChemBioChem, 2020
Helge B Bode
exaly   +2 more sources

A new fingerprint to predict nonribosomal peptides activity [PDF]

Journal of Computer-Aided Molecular Design, 2012
Valerie Leclere, Philippe Jacques
exaly   +2 more sources

Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics

Journal of Fungi, 2021
Previously, DNA microarrays analysis showed that, in co-culture with Bacillus subtilis, a biosynthetic gene cluster anchored with a nonribosomal peptides synthetase of Aspergillus niger is downregulated.
Gregory Evdokias, Cameron Semper, Montserrat Mora-Ochomogo, Marcos Di Falco, Thi Truc Minh Nguyen, Alexei Savchenko, Adrian Tsang, Isabelle Benoit-Gelber   +7 more
doaj   +1 more source

Nonribosomal Peptide Synthesis Definitely Working Out of the Rules

Microorganisms, 2022
Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields.
Matthieu Duban, Stéphane Cociancich, Valérie Leclère   +2 more
doaj   +1 more source

Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849^T

Fermentation, 2023
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has
Hisayuki Komaki, Tomohiko Tamura
doaj   +1 more source

Media development and process parameter optimization using statistical experimental designs for the production of nonribosomal peptides in Escherichia coli

Electronic Journal of Biotechnology, 2021
Background: Nonribosomal peptide synthases (NRPS) can synthesize functionally diverse bioactive peptides by incorporating nonproteinogenic amino acids, offering a rich source of new drug leads.
Arne Michael Oestreich, Merlinda Ilire Suli, Doreen Gerlach, Rong Fan, Peter Czermak   +4 more
doaj   +1 more source