Results 11 to 20 of about 10,782 (215)
, 2009 Nonribosomal peptides are a diverse group of compounds synthesized via modular nonribosomal peptide synthetase (NRPS) enzyme complexes. They are produced by a variety of prokaryotes, including streptomycetes, bacillus, and cyanobacteria, and lower-order eukaryotes such as fungi and sponges.
Roberts, Alexandra A. +2 more
core +4 more sources
Life, 2020 (1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites.
Hisayuki Komaki, Tomohiko Tamura
doaj +2 more sources
Flexing and Stretching in Nonribosomal Peptide Synthetases
Chemistry & Biology, 2012 Re-engineering of nonribosomal peptide synthetase molecular assembly lines has been hampered by a lack of detailed knowledge concerning inter-domain substrate transfer. Recent structural studies of catalytically relevant domain-domain interactions provide valuable insights into this problem (Liu et al., 2011; Sundlov et al., 2012 [in this issue of ...
Pfennig, Sabrina, Stubbs, Milton T.
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Decoding and reprogramming fungal iterative nonribosomal peptide synthetases
Nature Communications, 2017 Nonribosomal peptides are important bioactive molecules that are synthetized by enzymes containing several catalytic domains. Here the authors describe the catalytic mechanism of fungal nonribosomal peptide synthetases and present an approach to modify ...
Dayu Yu +3 more
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Nonribosomal Peptide Synthetases in Animals. [PDF]
Genes (Basel), 2023 Nonribosomal peptide synthetases (NRPSs) are a class of cytosolic enzymes that synthesize a range of bio-active secondary metabolites including antibiotics and siderophores. They are widespread among both prokaryotes and eukaryotes but are considered rare among animals.
Suring W +5 more
europepmc +4 more sources
Synthesis of the Nonribosomal Peptide Phevalin and Analogs
The Journal of Organic Chemistry, 2019 Phevalin, a cyclic nonribosomal peptide produced by Staphylococcus aureus, has intriguing biological properties. A synthetic route to access phevalin and similar pyrazinone natural products tyrvalin, leuvalin, phileucin, and a few synthetic analogs is described.
Remya Ramesh +3 more
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Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast [PDF]
Nature Communications, 2017 Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis ...
Ali R. Awan +6 more
doaj +2 more sources
PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases. [PDF]
JACS AuInternational audienceNonribosomal peptides are chemically and functionally diverse natural products with important applications in medicine and agriculture.
Terlouw BR +17 more
europepmc +3 more sources
Biosynthetic Functionalization of Nonribosomal Peptides
Journal of the American Chemical Society, 2021 Nonribosomal peptides (NRPs) are a therapeutically important class of secondary metabolites that are produced by modular synthetases in assembly-line fashion. We previously showed that a single Trp-to-Ser mutation in the initial Phe-loading adenylation domain of tyrocidine synthetase completely switches the specificity toward clickable analogues.
David L. Niquille +3 more
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A Nonribosomal System of Peptide Biosynthesis [PDF]
European Journal of Biochemistry, 1996 This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures.
H, Kleinkauf, H, Von Döhren
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