Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli [PDF]
BMC Genomics, 2019 Background Filamentous fungi produce a vast amount of bioactive secondary metabolites (SMs) synthesized by e.g. hybrid polyketide synthase-nonribosomal peptide synthetase enzymes (PKS-NRPS; NRPS-PKS).
Sebastian Theobald +2 more
doaj +5 more sources
NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases [PDF]
Nucleic Acids Research, 2004 NRPS-PKS is web-based software for analysing large multi-enzymatic, multi-domain megasynthases that are involved in the biosynthesis of pharmaceutically important natural products such as cyclosporin, rifamycin and erythromycin. NRPS-PKS has been developed based on a comprehensive analysis of the sequence and structural features of several ...
Mohd. Zeeshan Ansari +3 more
openaire +6 more sources
Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils. [PDF]
PLoS ONE, 2015 The ever increasing microbial resistome means there is an urgent need for new antibiotics. Metagenomics is an underexploited tool in the field of drug discovery. In this study we aimed to produce a new updated assay for the discovery of biosynthetic gene
Gregory C A Amos +9 more
doaj +3 more sources
Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering. [PDF]
PLoS ONE, 2016 Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions.
Maria Lund Nielsen +6 more
doaj +4 more sources
Advance on Transcription Factors Regulating the Synthesis of Secondary Metabolites Mediated by NRPS in Filamentous Fungi [PDF]
Shipin gongye ke-jiSecondary metabolites (SM) produced by filamentous fungi have been extensively applied in biomedicine, biological control, food, and other fields. The biosynthesis of most SMs is closely associated with the catalysis of non-ribosome peptide synthetase ...
Xiaoxuan BAI +4 more
doaj +3 more sources
Biotechnology and Biotechnological Equipment, 2020 The animal gut has a remarkable abundance of microbes. These microbes have strong potential for biosynthesis of promising drug candidates, and these small bioactive molecules often medicate important host–microbe and microbe–microbe interactions.
Can Song, Hui Lei, Xiurong Guo
exaly +2 more sources
PCR Optimization for Polyketide Synthase (PKS) and Non-Ribosomal Peptide Synthetase (NRPS) Gene Detection in Actinomycetes [PDF]
BIO Web of ConferencesActinomycetes are known as a group of antimicrobial-producing bacteria. This is supported by the presence of potential genes in actinomycetes bacteria. These genes include Polyketide Synthase (PKS) and Non-Ribosomal Peptide Synthetase (NRPS).
Prayekti Endah +3 more
doaj +5 more sources
Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated Paenibacillus species [PDF]
mSystemsThe growing threat of antimicrobial resistance necessitates the discovery of novel antibiotics with activity against drug-resistant pathogens. Members of the genus Paenibacillus are a rich source of nonribosomal peptides (NRPs), including well-known ...
Nataliia V. Machushynets +9 more
doaj +2 more sources
Actinomycetes of secondary metabolite producers from mangrove sediments, Central Java, Indonesia [PDF]
Veterinary World, 2021 Background and Aim: Actinomycetes are a group of Gram-positive bacteria with a fungus-like morphology. Their natural habitat encompasses terrestrial and water areas, including mangrove ecosystems.
Wilis Ari Setyati +3 more
doaj +1 more source
NRPS-related gene (C domain) identified in the bins using NaPDoS. [PDF]
, 2023 NRPS-related gene (C domain) identified in the bins using NaPDoS.
Kyohei Kuroda (3391319) +2 more
core +1 more source